Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Mattias Rickhag"'
Autor:
Mia Apuschkin, Hayley B. Burm, Jan H. Schmidt, Louise J. Skov, Rita C. Andersen, Carl-Fredrik Bowin, Jonatan F. Støier, Kathrine L. Jensen, Leonie P. Posselt, Oksana Dmytriyeva, Andreas T. Sørensen, Kristoffer L. Egerod, Birgitte Holst, Mattias Rickhag, Thue W. Schwartz, Ulrik Gether
Publikováno v:
Cell Reports, Vol 43, Iss 7, Pp 114509- (2024)
Summary: Midbrain dopaminergic neurons (DANs) are subject to extensive metabotropic regulation, but the repertoire of G protein-coupled receptors (GPCRs) present in these neurons has not been mapped. Here, we isolate DANs from Dat-eGFP mice to genera
Externí odkaz:
https://doaj.org/article/133a9c01bbf2442d97dd45f84df3014d
Autor:
Freja Herborg, Kathrine L. Jensen, Sasha Tolstoy, Natascha V. Arends, Leonie P. Posselt, Aparna Shekar, Jenny I. Aguilar, Viktor K. Lund, Kevin Erreger, Mattias Rickhag, Matthew D. Lycas, Markus N. Lonsdale, Troels Rahbek-Clemmensen, Andreas T. Sørensen, Amy H. Newman, Annemette Løkkegaard, Ole Kjærulff, Thomas Werge, for the iPSYCH researchers, Lisbeth B. Møller, Heinrich J.G. Matthies, Aurelio Galli, Lena E. Hjermind, Ulrik Gether
Publikováno v:
JCI Insight, Vol 6, Iss 18 (2021)
Dysfunctional dopaminergic neurotransmission is central to movement disorders and mental diseases. The dopamine transporter (DAT) regulates extracellular dopamine levels, but the genetic and mechanistic link between DAT function and dopamine-related
Externí odkaz:
https://doaj.org/article/0e76e431d1f8444ba28610dba3786a03
Autor:
Birgitte Holst, Kenneth L Madsen, Anna M Jansen, Chunyu Jin, Mattias Rickhag, Viktor K Lund, Morten Jensen, Vikram Bhatia, Gunnar Sørensen, Andreas N Madsen, Zhichao Xue, Siri K Møller, David Woldbye, Klaus Qvortrup, Richard Huganir, Dimitrios Stamou, Ole Kjærulff, Ulrik Gether
Publikováno v:
PLoS Biology, Vol 11, Iss 4, p e1001542 (2013)
Secretory vesicles in endocrine cells store hormones such as growth hormone (GH) and insulin before their release into the bloodstream. The molecular mechanisms governing budding of immature secretory vesicles from the trans-Golgi network (TGN) and t
Externí odkaz:
https://doaj.org/article/1b1e37beba824678913f7f38cf8eb86b
Publikováno v:
Neuroscience. 453:32-42
The striatum collects and integrates information from many different areas of the brain and propels this forward to the basal ganglia (BG) output structures. In this way, the striatum is playing a pivotal role in control of voluntary movements and is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9fd9be834949e37d4ffc8ca5263c7361
https://doi.org/10.1016/j.neuroscience.2020.11.035
https://doi.org/10.1016/j.neuroscience.2020.11.035
Publikováno v:
Journal of Neuroscience Research. 97:1181-1193
As the main input structure of the basal ganglia (BG), the striatum collects and integrates information from several brain areas and funnels them forward to other BG nuclei. The striatal projection neurons are medium-sized spiny neurons classified in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb5ed7070a100d3a6f3be3173c7cbc24
https://doi.org/10.1002/jnr.24479
https://doi.org/10.1002/jnr.24479
Autor:
Kevin Erreger, Mattias Rickhag, Leonie P. Posselt, Aparna Shekar, Aurelio Galli, Troels Rahbek-Clemmensen, Markus Nowak Lonsdale, Sasha Tolstoy, Annemette Løkkegaard, Amy Hauck Newman, Natascha V. Arends, Andreas T. Sørensen, Thomas Werge, Viktor K. Lund, Lisbeth Birk Møller, Jenny I. Aguilar, Ulrik Gether, Kathrine L. Jensen, Lena Elisabeth Hjermind, Matthew D. Lycas, Ole Kjaerulff, Heinrich J.G. Matthies, Freja Herborg
Publikováno v:
JCI Insight
Herborg, F, Jensen, K L, Tolstoy, S, Arends, N, Posselt, L P, Shekar, A, Aguilar, J, Lund, V K, Erreger, K, Rickhag, M, Lycas, M D, Lonsdale, M N, Rahbek-Clemmensen, T, Sorensen, A T, Newman, A H, Lokkegaard, A, Kjaerulff, O, Werge, T, Moller, L B, Matthies, H J G, Galli, A, Hjermind, L E, Gether, U & IPSYCH Researchers 2021, ' Identifying dominant-negative actions of a dopamine transporter variant in patients with parkinsonism and neuropsychiatric disease ', JCI insight, vol. 6, no. 18, 151496 . https://doi.org/10.1172/jci.insight.151496
Herborg, F, Jensen, K L, Tolstoy, S, Arends, N, Posselt, L P, Shekar, A, Aguilar, J, Lund, V K, Erreger, K, Rickhag, M, Lycas, M D, Lonsdale, M N, Rahbek-Clemmensen, T, Sorensen, A T, Newman, A H, Lokkegaard, A, Kjaerulff, O, Werge, T, Moller, L B, Matthies, H J G, Galli, A, Hjermind, L E, Gether, U & IPSYCH Researchers 2021, ' Identifying dominant-negative actions of a dopamine transporter variant in patients with parkinsonism and neuropsychiatric disease ', JCI insight, vol. 6, no. 18, 151496 . https://doi.org/10.1172/jci.insight.151496
Dysfunctional dopaminergic neurotransmission is central to movement disorders and mental diseases. The dopamine transporter (DAT) regulates extracellular dopamine levels, but the genetic and mechanistic link between DAT function and dopamine-related
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ca6cf7f70e973bb64f7b6009b997c20
https://pubmed.ncbi.nlm.nih.gov/34375312
https://pubmed.ncbi.nlm.nih.gov/34375312
Autor:
Gitta Wörtwein, Pia Weikop, Matthew D. Lycas, Pernille Herrstedt Ridderstrøm, Raul R. Gainetdinov, Gunnar Sørensen, Mattias Rickhag, Anders Fink-Jensen, David Pd Woldbye, Freja Herborg, Damiana Leo, Ulrik Gether
The dopamine transporter (DAT) is part of a presynaptic multi-protein network involving interactions with scaffold proteins via its C-terminal PDZ-domain binding sequence. In a mouse model expressing DAT with mutated PDZ binding sequence (DAT-AAA), w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6035d64efeec29f33ba5b15e48cc01d2
https://doi.org/10.1101/2021.01.06.425643
https://doi.org/10.1101/2021.01.06.425643
Autor:
Ulrik Gether, A. Loekkegaard, Andreas T. Sørensen, Natascha V. Arends, Aparna Shekar, Aurelio Galli, Freja Herborg, L. B. Moeller, Kenneth Jensen, Markus Nowak Lonsdale, Viktor K. Lund, Mattias Rickhag, Kevin Erreger, Amy Hauck Newman, Thomas Werge, Matthew D. Lycas, Ole Kjaerulff, S. Tolstoy, Jenny I. Aguilar, L. P. Posselt, Troels Rahbek-Clemmensen, Heinrich J.G. Matthies, Lena Elisabeth Hjermind
Dopaminergic dysfunction is central to movement disorders and mental diseases. The dopamine transporter (DAT) is essential for the regulation of extracellular dopamine but the genetic and mechanistic link between DAT function and dopamine-related pat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::af0f6e9d581a10325c3f789babc51d7b
https://doi.org/10.1101/2020.10.12.336461
https://doi.org/10.1101/2020.10.12.336461
Autor:
Matthew D. Lycas, Pia Weikop, Mattias Rickhag, Gitta Wörtwein, Raul R. Gainetdinov, Gunnar Sørensen, Damiana Leo, Jamila H. Lilja, Pedro Rifes, Pernille Herrstedt Ridderstrøm, Ulrik Gether, Freja Herborg, Anders Fink-Jensen, David P.D. Woldbye
Publikováno v:
Sørensen, G, Rickhag, M, Leo, D, Lycas, M D, Ridderstrøm, P H, Weikop, P, Lilja, J H, Rifes, P, Herborg, F, Woldbye, D, Wörtwein, G, Gainetdinov, R R, Fink-Jensen, A & Gether, U 2021, ' Disruption of the PDZ domain-binding motif of the dopamine transporter uniquely alters nanoscale distribution, dopamine homeostasis, and reward motivation ', Journal of Biological Chemistry, vol. 297, no. 6, 101361 . https://doi.org/10.1016/j.jbc.2021.101361
The Journal of Biological Chemistry
The Journal of Biological Chemistry
The dopamine transporter (DAT) is part of a presynaptic multi-protein network involving interactions with scaffold proteins via its C-terminal PDZ-domain binding sequence. Using a mouse model expressing DAT with mutated PDZ binding sequence (DAT-AAA)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e80451722f31d9f39c558cfd764ce7d5
https://doi.org/10.1016/j.jbc.2021.101361
https://doi.org/10.1016/j.jbc.2021.101361
Autor:
Heinrich J.G. Matthies, Alyssa West, Mark T. Wallace, Jenny I. Aguilar, Kyle E. Bundschuh, Fiona E. Harrison, Gabriella E. DiCarlo, Hao Chen, Freja Herborg, Ulrik Gether, Parastoo Hashemi, Mattias Rickhag, Aurelio Galli
Publikováno v:
DiCarlo, G E, Aguilar, J I, Matthies, H J G, Harrison, F E, Bundschuh, K E, West, A, Hashemi, P, Herborg, F, Rickhag, M, Chen, H, Gether, U, Wallace, M T & Galli, A 2019, ' Autism-linked dopamine transporter mutation alters striatal dopamine neurotransmission and dopamine-dependent behaviors ', Journal of Clinical Investigation, vol. 129, no. 8, pp. 3407-3419 . https://doi.org/10.1172/JCI127411
The precise regulation of synaptic dopamine (DA) content by the dopamine transporter (DAT) ensures the phasic nature of the DA signal, which underlies the ability of DA to encode reward prediction error, thereby driving motivation, attention, and beh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0df1a2b157e4a04ec6740bae05969ea7
https://pubmed.ncbi.nlm.nih.gov/31094705
https://pubmed.ncbi.nlm.nih.gov/31094705