Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Mattias Kalén"'
Autor:
Mattias Kalén, Tommi Heikura, Henna Karvinen, Anja Nitzsche, Holger Weber, Norbert Esser, Seppo Ylä-Herttuala, Mats Hellström
Publikováno v:
PLoS ONE, Vol 6, Iss 4, p e18709 (2011)
The Notch signaling pathway is essential for normal development due to its role in control of cell differentiation, proliferation and survival. It is also critically involved in tumorigenesis and cancer progression. A key enzyme in the activation of
Externí odkaz:
https://doaj.org/article/5c8072731f1447f98e77a3a190db4d38
Autor:
Hellmut G. Augustin, Thomas Korff, Markus Hecker, Mattias Kalén, Mats Hellström, Tobias May, Maximilian Heiss, Holger Weber
Publikováno v:
The FASEB Journal. 29:3076-3084
Given the need for robust and cost-efficient in vitro models to study angiogenesis and reproducibly analyze potential pro- and antiangiogenic compounds in preclinical studies, we developed a 3-dimensional in vitro angiogenesis assay that is based on
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::76a68c44cafa5e669bd661f00ed2244d
https://doi.org/10.1096/fj.14-267633
https://doi.org/10.1096/fj.14-267633
Autor:
Per Lindblom, Jennifer J. Hofmann, Li-Kun Phng, Janet Rossant, Elisabet Wallgard, Mattias Kalén, Jackelyn A. Alva, Leigh Coultas, Linda Karlsson, Christer Betsholtz, Nicholas Gaiano, Keejung Yoon, Holger Gerhardt, M. Luisa Iruela-Arispe, Ann Katrin Nilsson, Mats Hellström
Publikováno v:
Nature. 445:776-780
In sprouting angiogenesis, specialized endothelial tip cells lead the outgrowth of blood-vessel sprouts towards gradients of vascular endothelial growth factor (VEGF)-A. VEGF-A is also essential for the induction of endothelial tip cells, but it is n
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4e6864165328a3d48a1a9f4b87247548
https://doi.org/10.1038/nature05571
https://doi.org/10.1038/nature05571
Autor:
Noomi Asker, Reinhardt Fässler, Hans-Peter Hammes, Holger Gerhardt, Moshe Shani, Mattias Kalén, Mattias Bjarnegård, Maria Enge, Christer Betsholtz, Erika Gustafsson
Publikováno v:
The EMBO Journal. 21:4307-4316
Loss of pericytes from the capillary wall is a hallmark of diabetic retinopathy, however, the pathogenic significance of this phenomenon is unclear. In previous mouse gene knockout models leading to pericyte deficiency, prenatal lethality has so far
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22157047df3548a1be707fb2282331f8
https://doi.org/10.1093/emboj/cdf418
https://doi.org/10.1093/emboj/cdf418
Autor:
Christer Betsholtz, Mattias Kalén, Holger Gerhardt, Xuri Li, Hartwig Wolburg, Ulf Eriksson, Mats Hellström
Publikováno v:
The Journal of Cell Biology
The association of pericytes (PCs) to newly formed blood vessels has been suggested to regulate endothelial cell (EC) proliferation, survival, migration, differentiation, and vascular branching. Here, we addressed these issues using PDGF-B– and PDG
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f8ab0bccfa2557404eb8dd34f9b7e26a
http://europepmc.org/articles/PMC2190573
http://europepmc.org/articles/PMC2190573
Publikováno v:
Europe PubMed Central
Development of a vascular system involves the assembly of two principal cell types – endothelial cells and vascular smooth muscle cells/pericytes (vSMC/PC) – into many different types of blood vessels. Most, if not all, vessels begin as endotheli
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ed5e6d30cf5012234dc386d84d99cc6
https://doi.org/10.1242/dev.126.14.3047
https://doi.org/10.1242/dev.126.14.3047
Autor:
Xiaoyuan Guo, Jimmy Larsson, Mattias Kalén, Taija Makinen, Tommie Olofsson, Fredrik Pontén, Elisabet Wallgard, Mats Hellström, Anna Dimberg, Anja Nitzsche, Lothar C. Dieterich
Publikováno v:
Developmental dynamics : an official publication of the American Association of Anatomists. 241(4)
Background: Angiogenesis is implicated in many pathological conditions. The role of the proteins involved remains largely unknown, and few vascular-specific drug targets have been discovered. Previously, in a screen for angiogenesis regulators, we id
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb8642f2ea4706075ef8f435b5f37a00
https://pubmed.ncbi.nlm.nih.gov/22354871
https://pubmed.ncbi.nlm.nih.gov/22354871
Autor:
Anja Nitzsche, Norbert Esser, Tommi Heikura, Holger Weber, Mats Hellström, Mattias Kalén, Seppo Ylä-Herttuala, Henna Karvinen
Publikováno v:
PLoS ONE, Vol 6, Iss 4, p e18709 (2011)
PLoS ONE
PLoS ONE
The Notch signaling pathway is essential for normal development due to its role in control of cell differentiation, proliferation and survival. It is also critically involved in tumorigenesis and cancer progression. A key enzyme in the activation of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40d93ae5dd072b9ef458849cef572c7a
http://europepmc.org/articles/PMC3077402?pdf=render
http://europepmc.org/articles/PMC3077402?pdf=render
Autor:
Elisabet Athley, Erik Billgren, Noomi Asker, Jeffrey J. Essner, Ann Katrin Häger, Elizabeth Norseng, Hellmut G. Augustin, Shannon A. Wadman, Liqun He, Elisabet Wallgard, Chelsy K. Kemmet, Carly M. Utesch, Jon D. Larson, Mattias Kalén, Perry B. Hackett, Tore Samuelsson, Holger Weber, Aidas Nasevicius, Karl J. Clark, Linda Karlsson-Lindahl, Mats Hellström
Publikováno v:
Chemistrybiology. 16(4)
SummaryWe combined reverse and chemical genetics to identify targets and compounds modulating blood vessel development. Through transcript profiling in mice, we identified 150 potentially druggable microvessel-enriched gene products. Orthologs of 50
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e723069b519545a56ffb4a5d9babe7dd
https://pubmed.ncbi.nlm.nih.gov/19389629
https://pubmed.ncbi.nlm.nih.gov/19389629
Autor:
Cecilia Bondjers, John H. Kehrl, Hyeseon Cho, Mattias Kalén, Alexandra Abramsson, Oliver Renner, Per Lindahl, Mats Hellström, Christer Betsholtz, Stefan J. Scheidl
Publikováno v:
Scopus-Elsevier
All blood capillaries consist of endothelial tubes surrounded by mural cells referred to as pericytes. The origin, recruitment, and function of the pericytes is poorly understood, but the importance of these cells is underscored by the severe cardiov
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::86561c64d821502771264e3afe774446
https://europepmc.org/articles/PMC1868109/
https://europepmc.org/articles/PMC1868109/
