Zobrazeno 1 - 10
of 61
pro vyhledávání: '"Mattias Hällbrink"'
Autor:
Safa Bazaz, Tõnis Lehto, Rahel Tops, Olof Gissberg, Dhanu Gupta, Burcu Bestas, Jeremy Bost, Oscar P. B. Wiklander, Helena Sork, Eman M. Zaghloul, Doste R. Mamand, Mattias Hällbrink, Rannar Sillard, Osama Saher, Kariem Ezzat, C. I. Edvard Smith, Samir EL Andaloussi, Taavi Lehto
Publikováno v:
Biomedicines, Vol 9, Iss 8, p 1046 (2021)
Splice-switching therapy with splice-switching oligonucleotides (SSOs) has recently proven to be a clinically applicable strategy for the treatment of several mis-splice disorders. Despite this, wider application of SSOs is severely limited by the in
Externí odkaz:
https://doaj.org/article/299480288c2b4df49f3d5ab7d99ca7c2
Autor:
Oskar Gustafsson, Julia Rädler, Samantha Roudi, Tõnis Lehto, Mattias Hällbrink, Taavi Lehto, Dhanu Gupta, Samir EL Andaloussi, Joel Z. Nordin
Publikováno v:
Pharmaceutics, Vol 13, Iss 6, p 878 (2021)
The toolbox for genetic engineering has quickly evolved from CRISPR/Cas9 to a myriad of different gene editors, each with promising properties and enormous clinical potential. However, a major challenge remains: delivering the CRISPR machinery to the
Externí odkaz:
https://doaj.org/article/10d1eeb0a044486e802eb5b8d3dd2b19
Autor:
Moataz Dowaidar, Hani Nasser Abdelhamid, Mattias Hällbrink, Krista Freimann, Kaido Kurrikoff, Xiaodong Zou, Ülo Langel
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-11 (2017)
Abstract Magnetic nanoparticles (MNPs, Fe3O4) incorporated into the complexes of cell penetrating peptides (CPPs)-oligonucleotides (ONs) promoted the cell transfection for plasmid transfection, splice correction, and gene silencing efficiencies. Six
Externí odkaz:
https://doaj.org/article/c4631fac3dd145529679391dcb43aa18
Autor:
Helena Sork, Joel Z Nordin, Janne J Turunen, Oscar PB Wiklander, Burcu Bestas, Eman M Zaghloul, Helerin Margus, Kärt Padari, Adil D Duru, Giulia Corso, Jeremy Bost, Pieter Vader, Margus Pooga, CI Edvard Smith, Matthew JA Wood, Raymond M Schiffelers, Mattias Hällbrink, Samir EL Andaloussi
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 5, Iss C (2016)
The advantages of lipid-based transfection reagents have permitted their widespread use in molecular biology and gene therapy. This study outlines the effect of cryo-manipulation of a cationic lipid-based formulation, Lipofectamine 2000, which, after
Externí odkaz:
https://doaj.org/article/48a6da84132a4f1db17f5fc1b93f1a61
Autor:
Jeremy P Bost, Eman M. Zaghloul, Samir El Andaloussi, Rannar Sillard, Tõnis Lehto, C. I. Edvard Smith, Kariem Ezzat, Olof Gissberg, Safa Bazaz, Taavi Lehto, Osama Saher, Rahel Tops, Doste R. Mamand, Mattias Hällbrink, Burcu Bestas, Oscar P. B. Wiklander, Dhanu Gupta, Helena Sork
Publikováno v:
Biomedicines
Volume 9
Issue 8
Biomedicines, Vol 9, Iss 1046, p 1046 (2021)
Volume 9
Issue 8
Biomedicines, Vol 9, Iss 1046, p 1046 (2021)
Splice-switching therapy with splice-switching oligonucleotides (SSOs) has recently proven to be a clinically applicable strategy for the treatment of several mis-splice disorders. Despite this, wider application of SSOs is severely limited by the in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c0d60c67589cc5e0726d3afec061b42
Autor:
Harry Dolstra, Mark A.J. Gorris, Mattias Hällbrink, Emma Palmen, Alexander H. van Asbeck, Roland Brock, Leon F.A.G. Massuger, Dirk van den Brand, Inge Ebisch
Publikováno v:
European Journal of Pharmaceutics and Biopharmaceutics, 141, 180-190
European Journal of Pharmaceutics and Biopharmaceutics, 141, pp. 180-190
European Journal of Pharmaceutics and Biopharmaceutics, 141, pp. 180-190
Contains fulltext : 205181.pdf (Publisher’s version ) (Closed access) Ovarian cancer is the most lethal gynecological malignancy in the developed world. In spite of intensive research, the mortality has hardly decreased over the past twenty years.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8348a49141b6127aa9477e1c3d631af3
https://doi.org/10.1016/j.ejpb.2019.05.014
https://doi.org/10.1016/j.ejpb.2019.05.014
Autor:
Mattias Hällbrink, Marieke Willemse, Derick G. Wansink, Omar Paulino da Silva Filho, M. Leontien van der Bent, Roland Brock
Publikováno v:
The Faseb Journal, 33, 11314-11325
The Faseb Journal, 33, 10, pp. 11314-11325
The Faseb Journal, 33, 10, pp. 11314-11325
Item does not contain fulltext Antisense oligonucleotides (ASOs) are a promising class of therapeutics that are starting to emerge in the clinic. Determination of intracellular concentrations required for biologic effects and identification of effect
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dea09575976453a83da84dcd06c37beb
https://hdl.handle.net/2066/208585
https://hdl.handle.net/2066/208585
Publikováno v:
Journal of Biomaterials Applications. 33:392-401
Gene-based therapies, including the delivery of oligonucleotides, offer promising methods for the treatment of cancer cells. However, they have various limitations including low efficiency. Herein, cell-penetrating peptides (CPPs)-conjugated chitosan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7801dd826d4158716d1b260e40f3452f
https://doi.org/10.1177/0885328218796623
https://doi.org/10.1177/0885328218796623
Autor:
Mattias Hällbrink, Tõnis Lehto, Vlad Radoi, Luis Vasconcelos, Vladana Vukojević, Ülo Langel, Fatemeh Madani
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Biomembranes. 1860:491-504
Peptides able to translocate cell membranes while carrying macromolecular cargo, as cell-penetrating peptides (CPPs), can contribute to the field of drug delivery by enabling the transport of otherwise membrane impermeable molecules. Formation of non
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::88b4bc2d1681d73dfe77690ccc9b8f10
https://doi.org/10.1016/j.bbamem.2017.09.024
https://doi.org/10.1016/j.bbamem.2017.09.024
Publikováno v:
Biochimica et Biophysica Acta (BBA) - General Subjects. 1861:2334-2341
A new strategy for gene transfection using the nanocarrier of cell penetrating peptides (CPPs; PepFect14 (PF14) or PepFect14 (PF14) (PF221)) in complex with graphene oxide (GO) is reported. GO complexed with CPPs and plasmid (pGL3), splice correction
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e7d5c9258774faddc5b62f1af855f9c
https://doi.org/10.1016/j.bbagen.2017.07.002
https://doi.org/10.1016/j.bbagen.2017.07.002