Inhibition of vascular calcification by inositol phosphates derivatized with ethylene glycol oligomers

Autor: Antonia E. Schantl, Anja Verhulst, Ellen Neven, Geert J. Behets, Patrick C. D’Haese, Marc Maillard, David Mordasini, Olivier Phan, Michel Burnier, Dany Spaggiari, Laurent A. Decosterd, Mark G. MacAskill, Carlos J. Alcaide-Corral, Adriana A. S. Tavares, David E. Newby, Victoria C. Beindl, Roberto Maj, Anne Labarre, Chrismita Hegde, Bastien Castagner, Mattias E. Ivarsson, Jean-Christophe Leroux

Publikováno v: Nature Communications, Vol 11, Iss 1, Pp 1-17 (2020)

Cardiovascular calcification is a serious pathology for which effective pharmacological treatments are lacking. Here the authors show that an optimized oligo(ethylene glycol) derivative of inositol phosphate interferes with calcium phosphate crystall

Externí odkaz: https://doaj.org/article/af7eef951f974f1d9573843564c6bad9

A phytic acid analogue INS‐3001 prevents ectopic calcification in an Abcc6 −/− mouse model of pseudoxanthoma elasticum

Autor: Diana Li, Qiaoli Li, Ida Joely Jacobs, Jouni Uitto, Mattias E. Ivarsson

Publikováno v: Experimental Dermatology. 30:853-858

Pseudoxanthoma elasticum (PXE), a prototype of heritable ectopic calcification disorders, affects the skin, eyes and the cardiovascular system due to inactivating mutations in the ABCC6 gene. There is no effective treatment for the systemic manifesta

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::af130ea9c006344b8269f720353436a0
https://doi.org/10.1111/exd.14288

Investigational Therapies for Primary Hyperoxaluria

Autor: Mattias E. Ivarsson, Anna Kletzmayr, Jean-Christophe Leroux

Publikováno v: Bioconjugate Chemistry. 31:1696-1707

Recent years have brought exciting new insights in the field of primary hyperoxaluria (PH), both on a basic research level as well as through the progress of novel therapeutics in clinical development. To date, very few supportive measures are availa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61a47b25ffc858cc5357a00d06af060c
https://doi.org/10.1021/acs.bioconjchem.0c00268

Inhibition of vascular calcification by inositol phosphates derivatized with ethylene glycol oligomers

Autor: David Mordasini, Anne Labarre, Carlos J. Alcaide-Corral, Laurent A. Decosterd, Chrismita Hegde, Ellen Neven, Mark G. MacAskill, Marc Maillard, Dany Spaggiari, Michel Burnier, David E. Newby, Geert J. Behets, Bastien Castagner, Mattias E. Ivarsson, Patrick C. D'Haese, Antonia E. Schantl, Victoria C. Beindl, Adriana Tavares, Roberto Maj, Anja Verhulst, Jean-Christophe Leroux, Olivier Phan

Publikováno v: Schantl, A E, Verhulst, A, Neven, E, Behets, G J, D'Haese, P C, Maillard, M, Mordasini, D, Phan, O, Burnier, M, Spaggiari, D, Decosterd, L A, MacAskill, M G, Alcaide-Corral, C J, Tavares, A A S, Newby, D E, Beindl, V C, Maj, R, Labarre, A, Hedge, C, Castagner, B, Ivarsson, M E & Leroux, J-C 2020, ' Inhibition of vascular calcification by inositol phosphates derivatized with ethylene glycol oligomers ', Nature Communications, vol. 11, 721 . https://doi.org/10.1038/s41467-019-14091-4
Nature Communications, Vol 11, Iss 1, Pp 1-17 (2020)
Nature Communications
Nature communications, vol. 11, no. 1, pp. 721
Nature communications
Nature Communications, 11 (1)

Myo-inositol hexakisphosphate (IP6) is a natural product known to inhibit vascular calcification (VC), but with limited potency and low plasma exposure following bolus administration. Here we report the design of a series of inositol phosphate analog

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2fb9a8129d650ca324178fbd915550a3
https://www.pure.ed.ac.uk/ws/files/134711722/s41467_019_14091_4.pdf

Small-Molecule Allosteric Triggers of Clostridium difficile Toxin B Auto-proteolysis as a Therapeutic Strategy

Autor: Estelle Durantie, Susan M. Logan, Elena F. Verdu, Samuel Huwiler, Fernando Altamura, Bastien Castagner, Corina Huberli, Wangxue Chen, Jillian Friedman, Mattias E. Ivarsson, Jun Lu, Premysl Bercik, Chrismita Hegde, Jean-Christophe Leroux

Publikováno v: Cell Chemical Biology, 26 (1)

Summary Clostridium difficile causes increasing numbers of life-threatening intestinal infections. Symptoms associated with C. difficile infection (CDI) are mediated by secreted protein toxins, whose virulence is modulated by intracellular auto-prote

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::276a3bc9e41beb55d36a9b93b0a5dc7c
https://hdl.handle.net/20.500.11850/321156