Network analyses identify liver‐specific targets for treating liver diseases

Autor: Sunjae Lee, Cheng Zhang, Zhengtao Liu, Martina Klevstig, Bani Mukhopadhyay, Mattias Bergentall, Resat Cinar, Marcus Ståhlman, Natasha Sikanic, Joshua K Park, Sumit Deshmukh, Azadeh M Harzandi, Tim Kuijpers, Morten Grøtli, Simon J Elsässer, Brian D Piening, Michael Snyder, Ulf Smith, Jens Nielsen, Fredrik Bäckhed, George Kunos, Mathias Uhlen, Jan Boren, Adil Mardinoglu

Publikováno v: Molecular Systems Biology, Vol 13, Iss 8, Pp 1-15 (2017)

Abstract We performed integrative network analyses to identify targets that can be used for effectively treating liver diseases with minimal side effects. We first generated co‐expression networks (CNs) for 46 human tissues and liver cancer to expl

Externí odkaz: https://doaj.org/article/d25cec84bc19451aa968b418e06ff71b

Recurring intrahepatic cholestasis of pregnancy presents with distinct changes in the gut microbiota

Autor: Hanns-Ulrich Marschall, Peidi Liu, Sara Malcus, Mattias Bergentall, Tanweer Khan, Anita Lövgren-Sandblom, Peter Malcus, Gun Lindell, Fredrik Backhed, Ewa Wiberg-Itzel, Helena Strevens

Publikováno v: Journal of Hepatology. 77:S94

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::fd23213b174a3eef05b7303a1d87d631
https://doi.org/10.1016/s0168-8278(22)00579-7

An Integrated Understanding of the Rapid Metabolic Benefits of a Carbohydrate-Restricted Diet on Hepatic Steatosis in Humans

Autor: Adil, Mardinoglu, Hao, Wu, Elias, Bjornson, Cheng, Zhang, Antti, Hakkarainen, Sari M, Räsänen, Sunjae, Lee, Rosellina M, Mancina, Mattias, Bergentall, Kirsi H, Pietiläinen, Sanni, Söderlund, Niina, Matikainen, Marcus, Ståhlman, Per-Olof, Bergh, Martin, Adiels, Brian D, Piening, Marit, Granér, Nina, Lundbom, Kevin J, Williams, Stefano, Romeo, Jens, Nielsen, Michael, Snyder, Mathias, Uhlén, Göran, Bergström, Rosie, Perkins, Hanns-Ulrich, Marschall, Fredrik, Bäckhed, Marja-Riitta, Taskinen, Jan, Borén

A carbohydrate-restricted diet is a widely recommended intervention for non-alcoholic fatty liver disease (NAFLD), but a systematic perspective on the multiple benefits of this diet is lacking. Here, we performed a short-term intervention with an iso

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::31e769f6f32bdd0be6fd366bc87acb1c
http://hdl.handle.net/10138/233915

The gut microbiota modulates host amino acid and glutathione metabolism in mice

Autor: Cheng Cheng Zhang, Mattias Bergentall, Fredrik Bäckhed, Erik Larsson, Saeed Shoaie, Adil Mardinoglu, Jens Nielsen, Pouyan Ghaffari

Publikováno v: Molecular Systems Biology (1744-4292) vol.11(2015)
Mardinoglu, A, Bergentall, M, Ghaffari, P, Zhang, C, Larsson, E, Bäckhed, F, Nielsen, J & Shoaie, S 2015, ' The gut microbiota modulates host amino acid and glutathione metabolism in mice ', Molecular Systems Biology, vol. 11, no. 10, pp. 834 . https://doi.org/10.15252/msb.20156487
Molecular Systems Biology

The gut microbiota has been proposed as an environmental factor that promotes the progression of metabolic diseases. Here, we investigated how the gut microbiota modulates the global metabolic differences in duodenum, jejunum, ileum, colon, liver, an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28f68481c312acd5c402007d0e7f67cd
https://doi.org/10.15252/msb.20156487

Tissue factor and PAR1 promote microbiota-induced intestinal vascular remodelling

Autor: Wolfram Ruf, Florence Schaffner, Fredrik Bäckhed, Thomas U. Greiner, Christoph Reinhardt, Mattias Bergentall, Gunnel Östergren-Lundén, Lars Christian Petersen

Colonization of germ-free mice with microbiota promotes vascular growth in the small intestine through a mechanism involving tissue factor, PAR1 and Ang1. Colonization of germ-free mice with microbiota has been previously reported to promote vascular

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7659c7a30f5b57cee36c212eeab4a0ed
https://europepmc.org/articles/PMC3885420/