Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Mattia, Deluigi"'
Autor:
Mattia Deluigi, Lena Morstein, Matthias Schuster, Christoph Klenk, Lisa Merklinger, Riley R. Cridge, Lazarus A. de Zhang, Alexander Klipp, Santiago Vacca, Tasneem M. Vaid, Peer R. E. Mittl, Pascal Egloff, Stefanie A. Eberle, Oliver Zerbe, David K. Chalmers, Daniel J. Scott, Andreas Plückthun
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-13 (2022)
This study reports the X-ray structure of the α1B-adrenergic G protein-coupled receptor bound to an inverse agonist, and unveils key determinants of subtype-selective ligand binding that may help the design of aminergic drugs with fewer side-effects
Externí odkaz:
https://doaj.org/article/9eae3c81d8e34aff9e67ac17ad3df5fe
Autor:
Christian Baumann, Wan-Chin Chiang, Renato Valsecchi, Simon Jurt, Mattia Deluigi, Matthias Schuster, Andreas Plückthun, Oliver Zerbe
G protein-coupled receptors (GPCRs) are medically important membrane proteins that sample inactive, intermediate, and active conformational states characterized by relatively slow interconversions (∼μs– ms). On a faster timescale (∼ps–ns), t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a7549d4485eb27378a90370aa67389ea
https://doi.org/10.1101/2023.05.09.539984
https://doi.org/10.1101/2023.05.09.539984
Autor:
Mattia, Deluigi, Lena, Morstein, Matthias, Schuster, Christoph, Klenk, Lisa, Merklinger, Riley R, Cridge, Lazarus A, de Zhang, Alexander, Klipp, Santiago, Vacca, Tasneem M, Vaid, Peer R E, Mittl, Pascal, Egloff, Stefanie A, Eberle, Oliver, Zerbe, David K, Chalmers, Daniel J, Scott, Andreas, Plückthun
Publikováno v:
Nature Communications
α-adrenergic receptors (αARs) are G protein-coupled receptors that regulate vital functions of the cardiovascular and nervous systems. The therapeutic potential of αARs, however, is largely unexploited and hampered by the scarcity of subtype-selec
Autor:
Peer R. E. Mittl, Philipp Heine, S.A. Eberle, Santiago Vacca, Lisa Merklinger, Lena Morstein, Pascal Egloff, Mattia Deluigi, Patrick Ernst, Alexander Klipp, Andreas Plückthun, Theodore M. Kamenecka, Yuanjun He, Christoph Klenk, Annemarie Honegger
Publikováno v:
Science Advances
Crystal structures of NTSR1 bound to agonists, inverse agonists, and in the apo state enabled by a novel fusion to DARPin D12.
Neurotensin receptor 1 (NTSR1) and related G protein–coupled receptors of the ghrelin family are clinically unexploi
Neurotensin receptor 1 (NTSR1) and related G protein–coupled receptors of the ghrelin family are clinically unexploi
Autor:
Matthias, Schuster, Mattia, Deluigi, Milica, Pantić, Santiago, Vacca, Christian, Baumann, Daniel J, Scott, Andreas, Plückthun, Oliver, Zerbe
Publikováno v:
Biochimica et biophysica acta. Biomembranes. 1862(10)
Sample preparation for NMR studies of G protein-coupled receptors faces special requirements: Proteins need to be stable for prolonged measurements at elevated temperatures, they should ideally be uniformly labeled with the stable isotopes
Autor:
Feng-Jie Wu, Ross A. D. Bathgate, Daniel Scott, Andreas Plückthun, Tasneem M. Vaid, Mattia Deluigi, Kelvin J. Yong, Paul R. Gooley, Patrick J. Shilling, Lisa M. Williams
Publikováno v:
ACS Chemical Biology. 13:1090-1102
α1A- and α1B-adrenoceptors (α1A-AR and α1B-AR) are closely related G protein-coupled receptors (GPCRs) that modulate the cardiovascular and nervous systems in response to binding epinephrine and norepinephrine. The GPCR gene superfamily is made u
Autor:
Kelvin J, Yong, Tasneem M, Vaid, Patrick J, Shilling, Feng-Jie, Wu, Lisa M, Williams, Mattia, Deluigi, Andreas, Plückthun, Ross A D, Bathgate, Paul R, Gooley, Daniel J, Scott
Publikováno v:
ACS chemical biology. 13(4)
α
Publikováno v:
Protein expression and purification. 108
G protein-coupled receptors (GPCRs) are key players of cell signaling, thus representing important drug targets for the treatment of human diseases. Since inherent difficulties in receptor production and handling have precluded the application of man