Zobrazeno 1 - 10
of 84
pro vyhledávání: '"Matti Myllykoski"'
Autor:
Karen C. Heathcote, Thomas P. Keeley, Matti Myllykoski, Malin Lundekvam, Nina McTiernan, Salma Akter, Norma Masson, Peter J. Ratcliffe, Thomas Arnesen, Emily Flashman
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-15 (2024)
Abstract Oxygen homeostasis is maintained in plants and animals by O2-sensing enzymes initiating adaptive responses to low O2 (hypoxia). Recently, the O2-sensitive enzyme ADO was shown to initiate degradation of target proteins RGS4/5 and IL32 via th
Externí odkaz:
https://doaj.org/article/b131b08f851f4fecb899153290804823
Autor:
Marine Delamare, Amandine Le Roy, Mathilde Pacault, Loïc Schmitt, Céline Garrec, Nada Maaziz, Matti Myllykoski, Antoine Rimbert, Valéna Karaghiannis, Bernard Aral, Mark Catherwood, Fabrice Airaud, Lamisse Mansour-Hendili, David Hoogewijs, Edoardo Peroni, Salam Idriss, Valentine Lesieur, Amandine Caillaud, Karim Si-Tayeb, Caroline Chariau, Anne Gaignerie, Minke Rab, Torsten Haferlach, Manja Meggendorfer, Stéphane Bézieau, Andrea Benetti, Nicole Casadevall, Pierre Hirsch, Christian Rose, Mathieu Wemeau, Frédéric Galacteros, Bruno Cassinat, Beatriz Bellosillo, Celeste Bento, Richard van Wijk, Petro E. Petrides, Maria Luigia Randi, Mary Frances McMullin, Peppi Koivunen, François Girodon, Betty Gardie, ECYT consortium
Publikováno v:
Haematologica, Vol 108, Iss 11 (2023)
Hereditary erythrocytosis is a rare hematologic disorder characterized by an excess of red blood cell production. Here we describe a European collaborative study involving a collection of 2,160 patients with erythrocytosis sequenced in ten different
Externí odkaz:
https://doaj.org/article/3f9446a9e07d45d496f7af7a30c39bce
Publikováno v:
Data in Brief, Vol 20, Iss , Pp 1912-1916 (2018)
By far most macromolecular crystallographic data collection and experimental phasing is nowadays carried out using synchrotron radiation. Here, we present two crystallographic datasets collected on a home-source X-ray diffractometer, which can per se
Externí odkaz:
https://doaj.org/article/99ebde915a1143df9199c8ca659d41ce
Autor:
Arne Raasakka, Salla Ruskamo, Julia Kowal, Robert Barker, Anne Baumann, Anne Martel, Jussi Tuusa, Matti Myllykoski, Jochen Bürck, Anne S. Ulrich, Henning Stahlberg, Petri Kursula
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-18 (2017)
Abstract Compact myelin comprises most of the dry weight of myelin, and its insulative nature is the basis for saltatory conduction of nerve impulses. The major dense line (MDL) is a 3-nm compartment between two cytoplasmic leaflets of stacked myelin
Externí odkaz:
https://doaj.org/article/01e8e8607aeb49f7a8030653f1e6cce9
Autor:
Nicolas Snaidero, Caroline Velte, Matti Myllykoski, Arne Raasakka, Alexander Ignatev, Hauke B. Werner, Michelle S. Erwig, Wiebke Möbius, Petri Kursula, Klaus-Armin Nave, Mikael Simons
Publikováno v:
Cell Reports, Vol 18, Iss 2, Pp 314-323 (2017)
Summary: The myelin sheath is a multilamellar plasma membrane extension of highly specialized glial cells laid down in regularly spaced segments along axons. Recent studies indicate that myelin is metabolically active and capable of communicating wit
Externí odkaz:
https://doaj.org/article/cfd69d4c5ee14904b983587ef5908271
Autor:
Matti Myllykoski, Petri Kursula
Publikováno v:
PLoS ONE, Vol 12, Iss 1, p e0170355 (2017)
The 2H phosphoesterase family contains enzymes with two His-X-Ser/Thr motifs in the active site. 2H enzymes are found in all kingdoms of life, sharing little sequence identity despite the conserved overall fold and active site. For many 2H enzymes, t
Externí odkaz:
https://doaj.org/article/b105a2b579114881bc09472852d4b998
Publikováno v:
PLoS ONE, Vol 7, Iss 2, p e32336 (2012)
The 2',3'-cyclic nucleotide 3'-phosphodiesterase (CNPase) is a highly abundant membrane-associated enzyme in the myelin sheath of the vertebrate nervous system. CNPase is a member of the 2H phosphoesterase family and catalyzes the formation of 2'-nuc
Externí odkaz:
https://doaj.org/article/68f7d410aa484b529872d46c57bf4106
Autor:
Chaozhan Wang, Ute Neugebauer, Jochen Bürck, Matti Myllykoski, Peter Baumgärtel, Jürgen Popp, Petri Kursula
Publikováno v:
PLoS ONE, Vol 6, Iss 5, p e19915 (2011)
As an essential structural protein required for tight compaction of the central nervous system myelin sheath, myelin basic protein (MBP) is one of the candidate autoantigens of the human inflammatory demyelinating disease multiple sclerosis, which is
Externí odkaz:
https://doaj.org/article/ae594994583248cd974d24b6ae7bd4fa
Autor:
Kathryn Gunn, Matti Myllykoski, John Z. Cao, Manna Ahmed, Bofu Huang, Betty Rouaisnel, Bill H. Diplas, Michael M. Levitt, Ryan Looper, John G. Doench, Keith L. Ligon, Harley I. Kornblum, Samuel K. McBrayer, Hai Yan, Cihangir Duy, Lucy A. Godley, Peppi Koivunen, Julie-Aurore Losman
Publikováno v:
Cancer Discovery. :OF1-OF20
Oncogenic mutations in isocitrate dehydrogenase 1 (IDH1) and IDH2 occur in a wide range of cancers, including acute myeloid leukemia (AML) and glioma. Mutant IDH enzymes convert 2-oxoglutarate (2OG) to (R)-2-hydroxyglutarate [(R)-2HG], an oncometabol
Autor:
Julie-Aurore Losman, Peppi Koivunen, Lucy A. Godley, Cihangir Duy, Hai Yan, Samuel K. McBrayer, Harley I. Kornblum, Keith L. Ligon, John G. Doench, Ryan Looper, Michael M. Levitt, Bill H. Diplas, Betty Rouaisnel, Bofu Huang, Manna Ahmed, John Z. Cao, Matti Myllykoski, Kathryn Gunn
Inhibition of KDM5 enzymes by the (R)- and (S)-enantiomers of 2-hydroxyglutarate.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93bd98d6fef3b3201467d1983718c2c7
https://doi.org/10.1158/2159-8290.22726179
https://doi.org/10.1158/2159-8290.22726179