Induction of CD73 prevents death after emergency open aortic surgery for a ruptured abdominal aortic aneurysm: a randomized, double-blind, placebo-controlled study

Autor: Harri Hakovirta, Juho Jalkanen, Eija Saimanen, Tiia Kukkonen, Pekka Romsi, Velipekka Suominen, Leena Vikatmaa, Mika Valtonen, Matti K. Karvonen, Maarit Venermo, INFORAAA Study Group

Publikováno v: Scientific Reports, Vol 12, Iss 1, Pp 1-11 (2022)

Abstract Mortality remains high after emergency open surgery for a ruptured abdominal aortic aneurysm (RAAA). The aim of the present study was to assess, if intravenous (IV) Interferon (IFN) beta-1a improve survival after surgery by up-regulating Clu

Externí odkaz: https://doaj.org/article/4c62bac8c7a44267821d06f9a3f2f971

Data from Nonclinical Characterization of Bexmarilimab, a Clever-1–Targeting Antibody for Supporting Immune Defense Against Cancers

Autor: Jami Mandelin, Markku Jalkanen, Sirpa Jalkanen, Marita Vainio, Matti K. Karvonen, Jenna H. Rannikko, Mikael Maksimow, Maija Hollmén

Common lymphatic endothelial and vascular endothelial receptor-1 (Clever-1) is a multifunctional type-1 transmembrane protein that plays an important role in immunosuppression against tumors. Clever-1 is highly expressed in a subset of human tumor-as

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::86bc12e349c21784d7ca09469e1cd43e
https://doi.org/10.1158/1535-7163.c.6543514.v1

Supplementary Figure from Nonclinical Characterization of Bexmarilimab, a Clever-1–Targeting Antibody for Supporting Immune Defense Against Cancers

Autor: Jami Mandelin, Markku Jalkanen, Sirpa Jalkanen, Marita Vainio, Matti K. Karvonen, Jenna H. Rannikko, Mikael Maksimow, Maija Hollmén

Supplementary Figure from Nonclinical Characterization of Bexmarilimab, a Clever-1–Targeting Antibody for Supporting Immune Defense Against Cancers

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::98d89391c285a5443354eec9755a69c6
https://doi.org/10.1158/1535-7163.22522876.v1

Induction of CD73 Prevents Death after Emergency Open Aortic Surgery for a Ruptured Abdominal Aortic Aneurysm – A Randomized, Double-blind, Placebo-controlled Study

Autor: Pekka Romsi, Eija I. T. Saimanen, Maarit Venermo, Harri Hakovirta, Velipekka Suominen, Matti K Karvonen, Juho Jalkanen, Mika Valtonen, Leena Vikatmaa, Tiia Kukkonen

Background: Mortality remains high after emergency open surgery for a ruptured abdominal aortic aneurysm (RAAA). The aim of the present study was to assess, if intravenous (IV) Interferon (IFN) beta-1a improve survival after surgery by up-regulating

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a28139f366aeab8ef515ec553f760de1
https://doi.org/10.21203/rs.3.rs-732466/v2

Systemic Blockade of Clever-1 Elicits Lymphocyte Activation Alongside Checkpoint Molecule Downregulation in Patients with Solid Tumors : Results from a Phase I/II Clinical Trial

Autor: Reetta, Virtakoivu, Jenna H, Rannikko, Miro, Viitala, Felix, Vaura, Akira, Takeda, Tapio, Lönnberg, Jussi, Koivunen, Panu, Jaakkola, Annika, Pasanen, Shishir, Shetty, Maja J A, de Jonge, Debbie, Robbrecht, Yuk Ting, Ma, Tanja, Skyttä, Anna, Minchom, Sirpa, Jalkanen, Matti K, Karvonen, Jami, Mandelin, Petri, Bono, Maija, Hollmén

Publikováno v: Clinical Cancer Research : an official journal of the American Association for Cancer Research, 27(15), 4205-4220. American Association for Cancer Research Inc.

Purpose: Macrophages are critical in driving an immunosuppressive tumor microenvironment that counteracts the efficacy of T-cell–targeting therapies. Thus, agents able to reprogram macrophages toward a proinflammatory state hold promise as novel im

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::cc58c509c8ade075146fffca761c46ee
http://hdl.handle.net/10138/334630