Zobrazeno 1 - 10
of 87
pro vyhledávání: '"Matti Javanainen"'
Autor:
Federica Scollo, Carmelo Tempra, Hüseyin Evci, Miguel Riopedre-Fernandez, Agnieszka Olżyńska, Matti Javanainen, Arunima Uday, Marek Cebecauer, Lukasz Cwiklik, Hector Martinez-Seara, Pavel Jungwirth, Piotr Jurkiewicz, Martin Hof
Publikováno v:
Open Biology, Vol 14, Iss 9 (2024)
Calmodulin (CaM) is a ubiquitous calcium-sensitive messenger in eukaryotic cells. It was previously shown that CaM possesses an affinity for diverse lipid moieties, including those found on CaM-binding proteins. These facts, together with our observa
Externí odkaz:
https://doaj.org/article/948ba78addc24b15927c4da2d9483558
Autor:
Juho Liekkinen, Berta de Santos Moreno, Riku O. Paananen, Ilpo Vattulainen, Luca Monticelli, Jorge Bernardino de la Serna, Matti Javanainen
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 8 (2020)
Pulmonary surfactant is a complex mixture of lipids and proteins lining the interior of the alveoli, and constitutes the first barrier to both oxygen and pathogens as they progress toward blood circulation. Despite decades of study, the behavior of t
Externí odkaz:
https://doaj.org/article/8209e5ab9d3145aeb1c247cd64701baf
Autor:
Brayan Grau, Matti Javanainen, Maria Jesús García-Murria, Waldemar Kulig, Ilpo Vattulainen, Ismael Mingarro, Luis Martínez-Gil
Publikováno v:
Cell Stress, Vol 1, Iss 2, Pp 90-106 (2017)
Folding and packing of membrane proteins are highly influenced by the lipidic component of the membrane. Here, we explore how the hydrophobic mismatch (the difference between the hydrophobic span of a transmembrane protein region and the hydrophobic
Externí odkaz:
https://doaj.org/article/825e8dbc4a7646669a274827cbab9c25
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-10 (2017)
Abstract Biological membranes generate specific functions through compartmentalized regions such as cholesterol-enriched membrane nanodomains that host selected proteins. Despite the biological significance of nanodomains, details on their structure
Externí odkaz:
https://doaj.org/article/6acfacbd7e0742ddbe49ca6ba326a7a4
Autor:
Matti Javanainen, Giray Enkavi, Ramon Guixà-Gonzaléz, Waldemar Kulig, Hector Martinez-Seara, Ilya Levental, Ilpo Vattulainen
Publikováno v:
PLoS Computational Biology, Vol 15, Iss 5, p e1007033 (2019)
G protein-coupled receptors (GPCRs) control cellular signaling and responses. Many of these GPCRs are modulated by cholesterol and polyunsaturated fatty acids (PUFAs) which have been shown to co-exist with saturated lipids in ordered membrane domains
Externí odkaz:
https://doaj.org/article/44dbeddd82e9445e8f94075c1488fb35
Autor:
Su Duy Nguyen, Matti Javanainen, Sami Rissanen, Hongxia Zhao, Jenni Huusko, Annukka M. Kivelä, Seppo Ylä-Herttuala, Mohamad Navab, Alan M. Fogelman, Ilpo Vattulainen, Petri T. Kovanen, Katariina Öörni
Publikováno v:
Journal of Lipid Research, Vol 56, Iss 6, Pp 1206-1221 (2015)
Lipolytic modification of LDL particles by SMase generates LDL aggregates with a strong affinity for human arterial proteoglycans and may so enhance LDL retention in the arterial wall. Here, we evaluated the effects of apoA-I mimetic peptide 4F on st
Externí odkaz:
https://doaj.org/article/457a8b6e431347b194a1183cf8ea0cd0
Publikováno v:
PLoS ONE, Vol 12, Iss 11, p e0187936 (2017)
The coarse-grained Martini model is employed extensively to study membrane protein oligomerization. While this approach is exceptionally promising given its computational efficiency, it is alarming that a significant fraction of these studies demonst
Externí odkaz:
https://doaj.org/article/a6e48ec204ba4e6d8590dc57d39cc4a1
Autor:
Moutusi Manna, Miia Niemelä, Joona Tynkkynen, Matti Javanainen, Waldemar Kulig, Daniel J Müller, Tomasz Rog, Ilpo Vattulainen
Publikováno v:
eLife, Vol 5 (2016)
There is evidence that lipids can be allosteric regulators of membrane protein structure and activation. However, there are no data showing how exactly the regulation emerges from specific lipid-protein interactions. Here we show in atomistic detail
Externí odkaz:
https://doaj.org/article/f446eda416414c6794c93f0ff48cdfd5
Autor:
Tarja Äijänen, Artturi Koivuniemi, Matti Javanainen, Sami Rissanen, Tomasz Rog, Ilpo Vattulainen
Publikováno v:
PLoS Computational Biology, Vol 10, Iss 11, p e1003987 (2014)
Cholesteryl ester transfer protein (CETP) mediates the reciprocal transfer of neutral lipids (cholesteryl esters, triglycerides) and phospholipids between different lipoprotein fractions in human blood plasma. A novel molecular agent known as anacetr
Externí odkaz:
https://doaj.org/article/04613eab1bdb4a1885fca17a4069493a
Autor:
Maarit Neuvonen, Moutusi Manna, Sini Mokkila, Matti Javanainen, Tomasz Rog, Zheng Liu, Robert Bittman, Ilpo Vattulainen, Elina Ikonen
Publikováno v:
PLoS ONE, Vol 9, Iss 8, p e103743 (2014)
Bacterial cholesterol oxidase is commonly used as an experimental tool to reduce cellular cholesterol content. That the treatment also generates the poorly degradable metabolite 4-cholesten-3-one (cholestenone) has received less attention. Here, we i
Externí odkaz:
https://doaj.org/article/669fd9082c294e02ad5b0a311d8a0bce