Zobrazeno 1 - 10
of 332
pro vyhledávání: '"Matti, Poutanen"'
Autor:
Miguel A. Sánchez-Garrido, Víctor Serrano-López, Francisco Ruiz-Pino, María Jesús Vázquez, Andrea Rodríguez-Martín, Encarnación Torres, Inmaculada Velasco, Ana Belén Rodríguez, Eduardo Chicano-Gálvez, Marina Mora-Ortiz, Claes Ohlsson, Matti Poutanen, Leonor Pinilla, Francisco Gaytán, Jonathan D. Douros, Bin Yang, Timo D. Müller, Richard D. DiMarchi, Matthias H. Tschöp, Brian Finan, Manuel Tena-Sempere
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-20 (2024)
Abstract Polycystic ovary syndrome (PCOS) is a heterogeneous condition, defined by oligo-/anovulation, hyper-androgenism and/or polycystic ovaries. Metabolic complications are common in patients suffering PCOS, including obesity, insulin resistance a
Externí odkaz:
https://doaj.org/article/e9aa6128690c4c71b7909dd30b6ade0a
Autor:
Kimmo Kettunen, Julia Mathlin, Tarja Lamminen, Asta Laiho, Merja R. Häkkinen, Seppo Auriola, Laura L. Elo, Peter J. Boström, Matti Poutanen, Pekka Taimen
Publikováno v:
EBioMedicine, Vol 108, Iss , Pp 105359- (2024)
Summary: Background: Bladder cancer is a highly over-represented disease in males. The involvement of sex steroids in bladder carcinogenesis and the utilisation of steroid hormone action as a therapeutic target have been frequently proposed. However,
Externí odkaz:
https://doaj.org/article/d13519fb20bb47958a821925404ff551
Autor:
Sofia Kalinen, Teemu Kallonen, Marianne Gunell, Otto Ettala, Ivan Jambor, Juha Knaapila, Kari T. Syvänen, Pekka Taimen, Matti Poutanen, Hannu J. Aronen, Helena Ollila, Sami Pietilä, Laura L. Elo, Tarja Lamminen, Antti J. Hakanen, Eveliina Munukka, Peter J. Boström
Publikováno v:
European Urology Open Science, Vol 62, Iss , Pp 140-150 (2024)
Background: Although prostate cancer (PCa) is the most common cancer in men in Western countries, there is significant variability in geographical incidence. This might result from genetic factors, discrepancies in screening policies, or differences
Externí odkaz:
https://doaj.org/article/59d4e96f050142fcadb2f80340ba0515
Autor:
Sushma Marla, Sally Mortlock, Taija Heinosalo, Matti Poutanen, Grant W. Montgomery, Brett David McKinnon
Publikováno v:
BMC Medicine, Vol 21, Iss 1, Pp 1-15 (2023)
Abstract Background Endometriosis is a common, gynaecological disease characterised by the presence of endometrial-like cells growing outside the uterus. Lesions appear at multiple locations, present with variation in appearance, size and depth of in
Externí odkaz:
https://doaj.org/article/d2411956c2e84de6816c570237f39715
Autor:
Verneri Virtanen, Kreetta Paunu, Antti Kukkula, Saana Niva, Ylva Junila, Mervi Toriseva, Terhi Jokilehto, Sari Mäkelä, Riikka Huhtaniemi, Matti Poutanen, Ilkka Paatero, Maria Sundvall
Publikováno v:
Oncogenesis, Vol 12, Iss 1, Pp 1-12 (2023)
Abstract Lethal prostate cancer (PCa) is characterized by the presence of metastases and development of resistance to therapies. Metastases form in a multi-step process enabled by dynamic cytoskeleton remodeling. An actin cytoskeleton regulating gene
Externí odkaz:
https://doaj.org/article/bc81cdeac0e2439e9c19b849d1d94729
Autor:
Salli Talvi, Johanna Jokinen, Kalle Sipilä, Pekka Rappu, Fu-Ping Zhang, Matti Poutanen, Pia Rantakari, Jyrki Heino
Publikováno v:
iScience, Vol 27, Iss 2, Pp 108914- (2024)
Summary: Embigin (Gp70), a receptor for fibronectin and an ancillary protein for monocarboxylate transporters, is known to regulate stem cell niches in sebaceous gland and bone marrow. Here, we show that embigin expression is at high level during ear
Externí odkaz:
https://doaj.org/article/d136b79b5d374405a192181d8e634d5d
Autor:
Juha Saarikettu, Saara Lehmusvaara, Marko Pesu, Ilkka Junttila, Juha Partanen, Petra Sipilä, Matti Poutanen, Jie Yang, Teemu Haikarainen, Olli Silvennoinen
Publikováno v:
FASEB BioAdvances, Vol 5, Iss 5, Pp 183-198 (2023)
Abstract Snd1 is an evolutionarily conserved RNA‐binding protein implicated in several regulatory processes in gene expression including activation of transcription, mRNA splicing, and microRNA decay. Here, we have investigated the outcome of Snd1
Externí odkaz:
https://doaj.org/article/16f18b224da54a86aa8f9e82d02f1857
Autor:
Juan Roa, Miguel Ruiz-Cruz, Francisco Ruiz-Pino, Rocio Onieva, Maria J. Vazquez, Maria J. Sanchez-Tapia, Jose M. Ruiz-Rodriguez, Veronica Sobrino, Alexia Barroso, Violeta Heras, Inmaculada Velasco, Cecilia Perdices-Lopez, Claes Ohlsson, Maria Soledad Avendaño, Vincent Prevot, Matti Poutanen, Leonor Pinilla, Francisco Gaytan, Manuel Tena-Sempere
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-19 (2022)
Kiss1 neurons are essential for puberty and fertility. Here, the authors show that canonical microRNA biosynthesis in Kiss1 neurons plays an essential role in the control of puberty and fertility, especially in females, likely via repression of repre
Externí odkaz:
https://doaj.org/article/6b753545ed844d9184dfd67bb491e30f
Autor:
Kalle T. Rytkönen, Thomas Faux, Mehrad Mahmoudian, Taija Heinosalo, Mauris C. Nnamani, Antti Perheentupa, Matti Poutanen, Laura L. Elo, Günter P. Wagner
Publikováno v:
iScience, Vol 25, Iss 5, Pp 104235- (2022)
Summary: Trimethylation of histone H3 at lysine 4 (H3K4me3) is a marker of active promoters. Broad H3K4me3 promoter domains have been associated with cell type identity, but H3K4me3 dynamics upon cellular stress have not been well characterized. We a
Externí odkaz:
https://doaj.org/article/9dc03a5660ae47f3baf290543448e530
Autor:
Riikka Huhtaniemi, Petra Sipilä, Arttu Junnila, Riikka Oksala, Matias Knuuttila, Arfa Mehmood, Eija Aho, Teemu D. Laajala, Tero Aittokallio, Asta Laiho, Laura Elo, Claes Ohlsson, Malin Hagberg Thulin, Pekka Kallio, Sari Mäkelä, Mika V.J. Mustonen, Matti Poutanen
Publikováno v:
iScience, Vol 25, Iss 5, Pp 104287- (2022)
Summary: Antiandrogen treatment resistance is a major clinical concern in castration-resistant prostate cancer (CRPC) treatment. Using xenografts of VCaP cells we showed that growth of antiandrogen resistant CRPC tumors were characterized by a higher
Externí odkaz:
https://doaj.org/article/125d518783f44b70a3bc79f19094057c