Zobrazeno 1 - 10
of 65
pro vyhledávání: '"Matti, Leppänen"'
Autor:
Emilia A. Korhonen, Aino Murtomäki, Sawan Kumar Jha, Andrey Anisimov, Anne Pink, Yan Zhang, Simon Stritt, Inam Liaqat, Lukas Stanczuk, Laura Alderfer, Zhiliang Sun, Emmi Kapiainen, Abhishek Singh, Ibrahim Sultan, Anni Lantta, Veli-Matti Leppänen, Lauri Eklund, Yulong He, Hellmut G. Augustin, Kari Vaahtomeri, Pipsa Saharinen, Taija Mäkinen, Kari Alitalo
Publikováno v:
The Journal of Clinical Investigation, Vol 132, Iss 15 (2022)
Vascular endothelial growth factor C (VEGF-C) induces lymphangiogenesis via VEGF receptor 3 (VEGFR3), which is encoded by the most frequently mutated gene in human primary lymphedema. Angiopoietins (Angs) and their Tie receptors regulate lymphatic ve
Externí odkaz:
https://doaj.org/article/03f11650c1ac44279c6d8e5c233861e1
Autor:
Leena Tiainen, Emilia A. Korhonen, Veli-Matti Leppänen, Tiina Luukkaala, Mari Hämäläinen, Minna Tanner, Outi Lahdenperä, Pia Vihinen, Arja Jukkola, Peeter Karihtala, Sonja Aho, Eeva Moilanen, Kari Alitalo, Pirkko-Liisa Kellokumpu-Lehtinen
Publikováno v:
BMC Cancer, Vol 19, Iss 1, Pp 1-10 (2019)
Abstract Background Angiopoietin growth factors (Angs) regulate angiogenesis and lymphangiogenesis by binding to the endothelial Tie2 receptor. Ang2 expression is elevated in tissue hypoxia and inflammation, which also induce cleavage of the extracel
Externí odkaz:
https://doaj.org/article/cbbf93a5aff24e33b03d163c0d2624fd
Autor:
Sylvain Mukenge, Sawan K. Jha, Marco Catena, Elena Manara, Veli‐Matti Leppänen, Elisa Lenti, Daniela Negrini, Matteo Bertelli, Andrea Brendolan, Michael Jeltsch, Luca Aldrighetti
Publikováno v:
Molecular Genetics & Genomic Medicine, Vol 8, Iss 9, Pp n/a-n/a (2020)
Abstract Background Milroy‐like disease is the diagnostic definition used for patients with phenotypes that resemble classic Milroy disease (MD) but are negative to genetic testing for FLT4. In this study, we aimed at performing a genetic character
Externí odkaz:
https://doaj.org/article/31d2199b02cb47c58566f0fae40d1b7a
Autor:
Sawan Kumar Jha, Khushbu Rauniyar, Terhi Karpanen, Veli-Matti Leppänen, Pascal Brouillard, Miikka Vikkula, Kari Alitalo, Michael Jeltsch
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-13 (2017)
Abstract The collagen- and calcium-binding EGF domains 1 (CCBE1) protein is necessary for lymphangiogenesis. Its C-terminal collagen-like domain was shown to be required for the activation of the major lymphangiogenic growth factor VEGF-C (Vascular E
Externí odkaz:
https://doaj.org/article/d11b857cbde0493591e19aca144a0242
Autor:
Federico Innocenti, Kari K. Alitalo, Nancy Klauber-DeMore, Yuri K. Peterson, Carol E. Peña, Eleanor Hilliard, Amy S. Etheridge, Dylan M. Glubb, Veli-Matti Leppänen, Andrew D. Skol, Daniel J. Crona
Molecular markers of sorafenib efficacy in patients with metastatic renal cell carcinoma (mRCC) are not available. The purpose of this study was to discover genetic markers of survival in patients with mRCC treated with sorafenib. Germline variants f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::39aded848b246b299f1aa3935abcab2e
https://doi.org/10.1158/0008-5472.c.6510876.v1
https://doi.org/10.1158/0008-5472.c.6510876.v1
Autor:
Federico Innocenti, Kari K. Alitalo, Nancy Klauber-DeMore, Yuri K. Peterson, Carol E. Peña, Eleanor Hilliard, Amy S. Etheridge, Dylan M. Glubb, Veli-Matti Leppänen, Andrew D. Skol, Daniel J. Crona
Genotyped genes.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ea489788a0e11ae23909649e2b3d37f
https://doi.org/10.1158/0008-5472.22421274
https://doi.org/10.1158/0008-5472.22421274
Autor:
Federico Innocenti, Kari K. Alitalo, Nancy Klauber-DeMore, Yuri K. Peterson, Carol E. Peña, Eleanor Hilliard, Amy S. Etheridge, Dylan M. Glubb, Veli-Matti Leppänen, Andrew D. Skol, Daniel J. Crona
Expression of WT and T494A VEGFR-3 in HUVECs (A) and replication of phosphorylation experiments testing the effect of FLT4 rs307826 (A>G, T494A) on VEGFR-3 phosphorylation (B).
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0641778c94baf07333459e92bfb3613e
https://doi.org/10.1158/0008-5472.22421286.v1
https://doi.org/10.1158/0008-5472.22421286.v1
Autor:
Federico Innocenti, Kari K. Alitalo, Nancy Klauber-DeMore, Yuri K. Peterson, Carol E. Peña, Eleanor Hilliard, Amy S. Etheridge, Dylan M. Glubb, Veli-Matti Leppänen, Andrew D. Skol, Daniel J. Crona
SNP selection criteria, imputation and bioinformatic analyses
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::083dbc4ae37a828e48613de46e170706
https://doi.org/10.1158/0008-5472.22421277.v1
https://doi.org/10.1158/0008-5472.22421277.v1
Sedimenttien pilaantuneisuutta arvioidaan eri valtioissa monin eri tavoin ja eri näkökulmista, mutta monessa tapauksessa arvioiden pohjana ovat sedimentille laaditut haitta-ainekohtaiset ohje-, kynnys- tai raja-arvot tai ympäristönlaatunormit. En
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od______1593::851e9fed4dafb8a354a69d09b56fecd9
http://hdl.handle.net/10138/346144
http://hdl.handle.net/10138/346144
Autor:
Kari Alitalo, Veli-Matti Leppänen, Harri Nurmi, David T. Scadden, Hanna K. A. Mikkola, Shuo Chen, Michael Jeltsch, Lev Silberstein, Shentong Fang
Publikováno v:
Blood
Hematopoietic stem cells (HSCs) reside in the bone marrow (BM) stem cell niche, which provides a vital source of HSC regulatory signals. Radiation and chemotherapy disrupt the HSC niche, including its sinusoidal vessels and perivascular cells, contri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a075ce634db04b0df095d327f59d83cb
https://europepmc.org/articles/PMC7568034/
https://europepmc.org/articles/PMC7568034/