Zobrazeno 1 - 10
of 63
pro vyhledávání: '"Matthijs M Jore"'
Autor:
Maartje R. Inklaar, Roos M. de Jong, Ezra T. Bekkering, Hikaru Nagaoka, Felix L. Fennemann, Karina Teelen, Marga van de Vegte-Bolmer, Geert-Jan van Gemert, Rianne Stoter, C. Richter King, Nicholas I. Proellochs, Teun Bousema, Eizo Takashima, Takafumi Tsuboi, Matthijs M. Jore
Publikováno v:
npj Vaccines, Vol 8, Iss 1, Pp 1-8 (2023)
Abstract Malaria transmission-blocking vaccines (TBVs) aim to induce antibodies that block Plasmodium parasite development in the mosquito midgut, thus preventing mosquitoes from becoming infectious. While the Pro-domain and first of fourteen 6-Cyste
Externí odkaz:
https://doaj.org/article/873417ee2eae4bd1826b51bf24506c7a
Autor:
Kuang-Ting Ko, Frank Lennartz, David Mekhaiel, Bora Guloglu, Arianna Marini, Danielle J. Deuker, Carole A. Long, Matthijs M. Jore, Kazutoyo Miura, Sumi Biswas, Matthew K. Higgins
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-11 (2022)
Pfs48/45, a surface protein of Plasmodium falciparum, is a promising anti-malarial vaccine candidate whose structure is not entirely resolved. Here, the authors present the structure of the full-length molecule, and characterise the binding and activ
Externí odkaz:
https://doaj.org/article/1355932f57d3418087395ce9a33cabbe
Autor:
Katharina Braunger, Jiyoon Ahn, Matthijs M. Jore, Steven Johnson, Terence T. L. Tang, Dennis V. Pedersen, Gregers R. Andersen, Susan M. Lea
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-12 (2022)
Properdin is the only known positive regulator of the human complement system, stabilising the convertase C3 in the alternative pathway of complement activation. Here, the authors report the identification and characterisation of a species-specific p
Externí odkaz:
https://doaj.org/article/5b1add1310284327ac11638749c24bcd
Autor:
Surafel K. Tebeje, Wakweya Chali, Elifaged Hailemeskel, Jordache Ramjith, Abrham Gashaw, Temesgen Ashine, Desalegn Nebret, Endashaw Esayas, Tadele Emiru, Tizita Tsegaye, Karina Teelen, Kjerstin Lanke, Eizo Takashima, Takafumi Tsuboi, Nichole D. Salinas, Niraj H. Tolia, David Narum, Chris Drakeley, Benoit Witkowski, Amelie Vantaux, Matthijs M. Jore, William J. R. Stone, Ivo S. Hansen, Fitsum G. Tadesse, Teun Bousema
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 12 (2023)
Naturally acquired antibodies may reduce the transmission of Plasmodium gametocytes to mosquitoes. Here, we investigated associations between antibody prevalence and P. vivax infectivity to mosquitoes. A total of 368 microscopy confirmed P. vivax sym
Externí odkaz:
https://doaj.org/article/58a23394fab249ddb737615088050c79
Autor:
Susheel K. Singh, Jordan Plieskatt, Bishwanath K. Chourasia, Vandana Singh, Karin Lövgren Bengtsson, Jenny M. Reimer, Renate C. van Daalen, Karina Teelen, Marga van de Vegte-Bolmer, Geert-Jan van Gemert, Matthijs M. Jore, Michael Theisen
Publikováno v:
npj Vaccines, Vol 6, Iss 1, Pp 1-11 (2021)
Abstract The Plasmodium falciparum Pfs230 and Pfs48/45 proteins are leading candidates for a malaria transmission-blocking vaccine (TBV). Previously, we showed that a Pfs230–Pfs48/45 fusion protein elicits higher levels of functional antibodies tha
Externí odkaz:
https://doaj.org/article/d23619f475cb4d5dbe3391e5cc32c116
Autor:
Roos M. de Jong, Lisette Meerstein-Kessel, Dari F. Da, Sandrine Nsango, Joseph D. Challenger, Marga van de Vegte-Bolmer, Geert-Jan van Gemert, Elias Duarte, Noam Teyssier, Robert W. Sauerwein, Thomas S. Churcher, Roch K. Dabire, Isabelle Morlais, Emily Locke, Martijn A. Huynen, Teun Bousema, Matthijs M. Jore
Publikováno v:
npj Vaccines, Vol 6, Iss 1, Pp 1-9 (2021)
Abstract Malaria parasite transmission to mosquitoes relies on the uptake of sexual stage parasites during a blood meal and subsequent formation of oocysts on the mosquito midgut wall. Transmission-blocking vaccines (TBVs) and monoclonal antibodies (
Externí odkaz:
https://doaj.org/article/852c3163e8664f10865e9f61f43db532
Autor:
Roos M. de Jong, Susheel K. Singh, Karina Teelen, Marga van de Vegte-Bolmer, Geert-Jan van Gemert, Will J. R. Stone, Emily Locke, Jordan Plieskatt, Michael Theisen, Teun Bousema, Matthijs M. Jore
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Malaria transmission blocking vaccines (TBV) aim to induce antibodies that can interrupt Plasmodium falciparum development in the mosquito midgut and thereby prevent onward malaria transmission. A limited number of TBV candidates have been identified
Externí odkaz:
https://doaj.org/article/5eb064a5bbc444078aa8aae5c7b6d44b
Autor:
Amanda Fabra-García, Annie S.P. Yang, Marije C. Behet, Zen Yap, Youri van Waardenburg, Swarnendu Kaviraj, Kjerstin Lanke, Geert-Jan van Gemert, Matthijs M. Jore, Teun Bousema, Robert W. Sauerwein
Publikováno v:
JCI Insight, Vol 7, Iss 6 (2022)
Sporozoite-based approaches currently represent the most effective vaccine strategies for induction of sterile protection against Plasmodium falciparum (Pf) malaria. Clinical development of subunit vaccines is almost exclusively centered on the circu
Externí odkaz:
https://doaj.org/article/2437a79826e644e085089a7a607a1d6e
Autor:
Susheel K. Singh, Jordan Plieskatt, Bishwanath K. Chourasia, Amanda Fabra-García, Asier Garcia-Senosiain, Vandana Singh, Karin Lövgren Bengtsson, Jenny M. Reimer, Robert Sauerwein, Matthijs M. Jore, Michael Theisen
Publikováno v:
Frontiers in Immunology, Vol 11 (2021)
The cysteine-rich Pfs48/45 protein, a Plasmodium falciparum sexual stage surface protein, has been advancing as a candidate antigen for a transmission-blocking vaccine (TBV) for malaria. However, Pfs48/45 contains multiple disulfide bonds, that are c
Externí odkaz:
https://doaj.org/article/abac308fce534339b9649af5cb94636e
Autor:
Prasun Kundu, Anthony Semesi, Matthijs M. Jore, Merribeth J. Morin, Virginia L. Price, Alice Liang, Jingxing Li, Kazutoyo Miura, Robert W. Sauerwein, C. Richter King, Jean-Philippe Julien
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-9 (2018)
Malaria protein Pfs48/45 is a promising transmission-blocking antigen targeted by antibodies. Here, the authors determine the structure of its transmission-blocking epitope I, and generate a humanized monoclonal antibody that binds Pfs48/45 with high
Externí odkaz:
https://doaj.org/article/f164d6aeda444b7184cfe6f2d8f3cc0d