Zobrazeno 1 - 10
of 232
pro vyhledávání: '"Matthijs K C Hesselink"'
Autor:
Yvonne M H Bruls, Yvo J M Op den Kamp, Esther Phielix, Lucas Lindeboom, Bas Havekes, Gert Schaart, Esther Moonen-Kornips, Joachim E Wildberger, Matthijs K C Hesselink, Patrick Schrauwen, Vera B Schrauwen-Hinderling
Publikováno v:
PLoS ONE, Vol 15, Iss 9, p e0239506 (2020)
BackgroundLow carnitine status may underlie the development of insulin resistance and metabolic inflexibility. Intravenous lipid infusion elevates plasma free fatty acid (FFA) concentration and is a model for simulating insulin resistance and metabol
Externí odkaz:
https://doaj.org/article/3aa7b54fb6b249e0a6e6904ab28a4607
Autor:
Christian Roy, Sabina Paglialunga, Gert Schaart, Esther Moonen-Kornips, Ruth C Meex, Esther Phielix, Joris Hoeks, Matthijs K C Hesselink, Katherine Cianflone, Patrick Schrauwen
Publikováno v:
PLoS ONE, Vol 8, Iss 2, p e57494 (2013)
ObjectiveTo investigate the role of Acylation Stimulating Protein (ASP) receptor C5L2 in skeletal muscle fatty acid accumulation and metabolism as well as insulin sensitivity in both mice and human models of diet-induced insulin resistance.Design and
Externí odkaz:
https://doaj.org/article/6ae46696de1d449fbb497be7e2226bd8
Autor:
Silvie Timmers, Johan de Vogel-van den Bosch, Matthijs K C Hesselink, Denis van Beurden, Gert Schaart, Maria Joao Ferraz, Mario Losen, Pilar Martinez-Martinez, Marc H De Baets, Johannes M F G Aerts, Patrick Schrauwen
Publikováno v:
PLoS ONE, Vol 6, Iss 1, p e14503 (2011)
BackgroundThe involvement of muscle triacylglycerol (TAG) storage in the onset of insulin resistance is questioned and the attention has shifted towards inhibition of insulin signalling by the lipid intermediate diacylglycerol (DAG). The enzyme 1,2-a
Externí odkaz:
https://doaj.org/article/ad75f3a726a74f138354472eda7e5d3b
Autor:
Jordi P. D. Kleinloog, Ronald P. Mensink, Jos op’t. Roodt, Dick H. J. Thijssen, Matthijs K. C. Hesselink, Peter J. Joris
Publikováno v:
Physiological Reports, Vol 10, Iss 16, Pp n/a-n/a (2022)
Abstract It is well‐known that aerobic exercise training beneficially affects endothelial function as measured by brachial artery flow‐mediated vasodilation (FMD). This trial with older sedentary overweight and obese men, therefore, examined the
Externí odkaz:
https://doaj.org/article/484a271a78c241fbafd3ed0d3d7e03ca
Autor:
Melissa L. Erickson, Jacob M. Allen, Daniel P. Beavers, Linda M. Collins, Karina W. Davidson, Kirk I. Erickson, Karyn A. Esser, Matthijs K. C. Hesselink, Kerrie L. Moreau, Eric B. Laber, Charlotte A. Peterson, Courtney M. Peterson, Jane E. Reusch, John P. Thyfault, Shawn D. Youngstedt, Juleen R. Zierath, Bret H. Goodpaster, Nathan K. LeBrasseur, Thomas W. Buford, Lauren M. Sparks
Publikováno v:
Geroscience, 45(1), 569-589. Springer International Publishing
Abstract Exercise is a cornerstone of preventive medicine and a promising strategy to intervene on the biology of aging. Variation in the response to exercise is a widely accepted concept that dates back to the 1980s with classic genetic studies iden
Autor:
Sten M. M. van Beek, Yvonne M. H. Bruls, Froukje Vanweert, Ciarán E. Fealy, Niels J. Connell, Gert Schaart, Esther Moonen-Kornips, Johanna A. Jörgensen, Frédéric M. Vaz, Ellen T. H. C. Smeets, Peter J. Joris, Anne Gemmink, Riekelt H. Houtkooper, Matthijs K. C. Hesselink, Tore Bengtsson, Bas Havekes, Patrick Schrauwen, Joris Hoeks
Publikováno v:
Nature communications, 14(1):173. Nature Publishing Group
Nature Communications, 14(1):173. Nature Publishing Group
Nature Communications, 14(1):173. Nature Publishing Group
beta(2)-agonist treatment improves skeletal muscle glucose uptake and whole-body glucose homeostasis in rodents, likely via mTORC2-mediated signalling. However, human data on this topic is virtually absent. We here investigate the effects of two-week
Autor:
Jeroen H. P. M. van der Velde, Sebastiaan C. Boone, Esther Winters-van Eekelen, Matthijs K. C. Hesselink, Vera B. Schrauwen-Hinderling, Patrick Schrauwen, Hildo J. Lamb, Frits R. Rosendaal, Renée de Mutsert
Publikováno v:
Diabetologia. SPRINGER
Diabetologia
Diabetologia, 66, 461-471. Springer, Cham
Diabetologia
Diabetologia, 66, 461-471. Springer, Cham
Aims/hypothesis We hypothesised that the insulin-sensitising effect of physical activity depends on the timing of the activity. Here, we examined cross-sectional associations of breaks in sedentary time and timing of physical activity with liver fat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad7a086893c8d477a10a0ecfc3d0d565
http://hdl.handle.net/1887/3513955
http://hdl.handle.net/1887/3513955
Autor:
Patrick Schrauwen, Vera B. Schrauwen-Hinderling, Lena Bilet, Esther Phielix, Esther Moonen-Kornips, Nynke van Polanen, Matthijs K. C. Hesselink, Sabine Daemen
Publikováno v:
American Journal of Physiology : Endocrinology and Metabolism, 321(4), E453-E463. American Physiological Society
Intramyocellular lipid (IMCL) content is an energy source during acute exercise. Nonesterified fatty acid (NEFA) levels can compete with IMCL utilization during exercise. IMCL content is stored as lipid droplets (LDs) that vary in size, number, subce
Autor:
Patrick Schrauwen, Carlijn M. E. Remie, Vera H. W. de Wit, Joris Hoeks, Esther Phielix, Matthijs K. C. Hesselink, Vera B. Schrauwen-Hinderling, Georges E. Janssens, L. Bilet, Bernard M. F. M. Duvivier, Bauke V. Schomakers, Michel van Weeghel, Niels J. Connell, Riekelt H. Houtkooper, Johanna A. Jörgensen
Publikováno v:
Diabetologia, 64(12), 2817-2828. Springer, Cham
Diabetologia
Diabetologia, 64(12), 2817-2828. Springer Verlag
Diabetologia
Diabetologia, 64(12), 2817-2828. Springer Verlag
Aims/hypothesis In our current society sedentary behaviour predominates in most people and is associated with the risk of developing type 2 diabetes. It has been suggested that replacing sitting time by standing and walking could be beneficial for in
Autor:
Marlies de Ligt, Johanna A. Jörgensen, Matthijs K. C. Hesselink, Gijs H. Goossens, Johan W. E. Jocken, Ellen E. Blaak
Publikováno v:
Obesity (Silver Spring, Md.)
Obesity, 29(9), 1423-1426. Wiley
Obesity, 29(9), 1423-1426. Wiley
Objective Severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2) uses the host's angiotensin-converting enzyme 2 (ACE2) as a cellular entry point. Therefore, modulating ACE2 might impact SARS-CoV-2 viral replication, shedding, and coronavirus d