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of 8
pro vyhledávání: '"Matthieu Y. Pasco"'
Autor:
Matthieu Y. Pasco, Hélène Catoire, J. Alex Parker, Bernard Brais, Guy A. Rouleau, Christian Néri
Publikováno v:
Neurobiology of Disease, Vol 38, Iss 3, Pp 425-433 (2010)
Developmental pathways may be play a role in adult cell survival. However, whether they interact with longevity/cell survival pathways to confer protection against disease-associated proteotoxicity remains largely unknown. We previously reported that
Externí odkaz:
https://doaj.org/article/00cc8ae795bb4c9bbbbba360dc981c62
Autor:
Matthieu Y Pasco, Pierre Léopold
Publikováno v:
PLoS ONE, Vol 7, Iss 5, p e36583 (2012)
In multicellular organisms, insulin/IGF signaling (IIS) plays a central role in matching energy needs with uptake and storage, participating in functions as diverse as metabolic homeostasis, growth, reproduction and ageing. In mammals, this pleiotrop
Externí odkaz:
https://doaj.org/article/6e8b523002484f9d959c0d0bfc857816
Autor:
Lucia Altucci, Guy A. Rouleau, Dante Rotili, Francesca Farina, Christian Neri, Matthieu Y. Pasco, Antonello Mai
Publikováno v:
Journal of Medicinal Chemistry
In oculopharyngeal muscular dystrophy (OPMD), a disease caused by polyalanine expansion in the nuclear protein PABPN1, the genetic inhibition of sirtuins and treatment with sirtuin inhibitors protect from mutant PABPN1 toxicity in transgenic nematode
Autor:
Matthieu Y. Pasco, Cendrine Tourette, Bernard Brais, Christian Neri, Hélène Catoire, Guy A. Rouleau, J. Alex Parker, Sébastien Holbert, Aida Abu-Baker
Publikováno v:
Human Molecular Genetics
Human Molecular Genetics, Oxford University Press (OUP), 2008, 17 (14), pp.2108-2117. ⟨10.1093/hmg/ddn109⟩
Human Molecular Genetics, Oxford University Press (OUP), 2008, 17 (14), pp.2108-2117. ⟨10.1093/hmg/ddn109⟩
International audience; Oculopharyngeal muscular dystrophy (OPMD) is caused by polyalanine expansion in nuclear protein PABPN1 [poly(A) binding protein nuclear 1] and characterized by muscle degeneration. Druggable modifiers of proteotoxicity in dege
Autor:
Sean Tenant, Evangelia K. Ttofi, Claire H. Michel, David C. Rubinsztein, Matthieu Y. Pasco, Cahir J. O'Kane, Zdenek Berger
Publikováno v:
Human Molecular Genetics. 14:3003-3011
We have previously shown that lithium can protect against the polyglutamine toxicity of the Huntington's disease mutation in cell models. Here, we demonstrate for the first time in vivo that lithium can protect against the toxicity caused by aggregat
Autor:
Lynnette J. Cook, Axelle Cordenier, Zdenek Berger, David C. Rubinsztein, Sovan Sarkar, Sara Imarisio, R. Andres Floto, Matthieu Y. Pasco
Publikováno v:
The Journal of Cell Biology
Macroautophagy is a key pathway for the clearance of aggregate-prone cytosolic proteins. Currently, the only suitable pharmacologic strategy for up-regulating autophagy in mammalian cells is to use rapamycin, which inhibits the mammalian target of ra
Autor:
J. Alex Parker, Bernard Brais, Hélène Catoire, Guy A. Rouleau, Matthieu Y. Pasco, Christian Neri
Publikováno v:
Neurobiology of Disease, Vol 38, Iss 3, Pp 425-433 (2010)
Developmental pathways may be play a role in adult cell survival. However, whether they interact with longevity/cell survival pathways to confer protection against disease-associated proteotoxicity remains largely unknown. We previously reported that
Autor:
Matthieu Y. Pasco, David C. Rubinsztein, Shouqing Luo, Irina Majoul, Zdenek Berger, Janet E. Davies, Cahir J. O'Kane
Publikováno v:
Human molecular genetics. 15(3)
Many aggregate-prone proteins, including proteins with long polyglutamine or polyalanine tracts, cause human diseases. Polyalanine proteins may also be present in the tissue of polyglutamine diseases as a result of frameshifting of the primary polygl