Zobrazeno 1 - 10
of 46
pro vyhledávání: '"Matthieu Stettler"'
Autor:
Sören Werner, David Hacker, Lucia Baldi, Rolf Tanner, Markus Kühner, Gilles Broccard, Cedric Bürkie, Stephanie Tissot, Matthieu Stettler, Xiaowei Zhang, Maria De Jesus, Dieter Eibl, Marcel Röll, Christine Lettenbauer, Regine Eibl, Florian M. Wurm
Publikováno v:
CHIMIA, Vol 64, Iss 11 (2010)
Innovative mixing principles in bioreactors, for example using the rocking of a platform to induce a backwards and forwards 'wave' , or using orbital shaking to generate a 'wave' that runs round in a cylindrical container, have proved to be successfu
Externí odkaz:
https://doaj.org/article/f26607f9f1264f98b77cb4db636a6d60
Publikováno v:
Current Opinion in Chemical Engineering. 22:253-257
Manufacturers of recombinant proteins frequently face the challenge to satisfy the market needs with existing large scale production capacity. For fed-batch processes, the maximal capacity is given in yield per batch multiplied by the number of runs
Autor:
Massimo Morbidelli, Hervé Broly, Martin Jordan, Alessandro Butté, David Brühlmann, Matthieu Stettler, Raphael Ducommun, Philipp Zürcher, Michael Sokolov, Jonathan Souquet
Publikováno v:
Biotechnology Progress. 36
Multivariate latent variable methods have become a popular and versatile toolset to analyze bioprocess data in industry and academia. This work spans such applications from the evaluation of the role of the standard process variables and metabolites
Autor:
Martin Jordan, Michael Sokolov, Hervé Broly, Jonathan Souquet, Massimo Morbidelli, Philipp Zürcher, David Brühlmann, Alessandro Butté, Matthieu Stettler, Raphael Ducommun
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dfb4b99a0c65274a88a9e3699efee044
https://doi.org/10.1002/btpr.3012/v2/response1
https://doi.org/10.1002/btpr.3012/v2/response1
Autor:
Vania Bertrand, Sebastian Vogg, Massimo Morbidelli, Matthieu Stettler, Miroslav Soos, Hervé Broly, Thomas K. Villiger
Publikováno v:
Journal of Biotechnology. 279:27-36
The pharmaceutical production of recombinant proteins, such as monoclonal antibodies, is rather complex and requires proper development work. Accordingly, it is essential to develop appropriate scale-down models, which can mimic the corresponding pro
Autor:
Massimo Morbidelli, Eric Lucas, Thomas K. Villiger, Matthieu Stettler, Benjamin Neunstoecklin, Daniel J. Karst, Hervé Broly, Miroslav Soos
Publikováno v:
Biochemical Engineering Journal. 131:84-94
Transfer of mammalian cell culture processes across stirred and aerated bioreactor scales is a delicate task, frequently leading to different conditions across scales. To provide a more rational reasoning behind scale-up of mammalian cell cultures, p
Autor:
Matthieu Stettler, Thomas K. Villiger, Hervé Broly, Massimo Morbidelli, Jean-Marc Bielser, Miroslav Soos, Jonathan Souquet, Elisa Serra, Ernesto Scibona, Daniel J. Karst
Publikováno v:
Biotechnology and Bioengineering. 114:1978-1990
Mammalian cell perfusion cultures are gaining renewed interest as an alternative to traditional fed-batch processes for the production of therapeutic proteins, such as monoclonal antibodies (mAb). The steady state operation at high viable cell densit
Autor:
Miroslav Soos, Jean-Marc Bielser, Matthieu Stettler, Jonathan Souquet, Jonathan Ritscher, Nicola MacKinnon, Gian Thanei, Michael Sokolov, Massimo Morbidelli, Alessandro Butté, Hervé Broly, David Brühlmann, Dominik Rothenhäusler
Publikováno v:
Biotechnology Progress. 33:181-191
This work presents a multivariate methodology combining principal component analysis, the Mahalanobis distance and decision trees for the selection of process factors and their levels in early process development of generic molecules. It is applied t
Autor:
Matthieu Stettler, Massimo Morbidelli, Miroslav Soos, Thomas K. Villiger, Hervé Broly, Ernesto Scibona
Publikováno v:
Biotechnology Progress. 32:1135-1148
N-linked glycosylation is known to be a crucial factor for the therapeutic efficacy and safety of monoclonal antibodies (mAbs) and many other glycoproteins. The nontemplate process of glycosylation is influenced by external factors which have to be t
Autor:
Hervé Broly, Matthieu Stettler, Massimo Morbidelli, Anaïs Roulet, Thomas K. Villiger, Arnaud Périlleux, Miroslav Soos
Publikováno v:
Biotechnology Progress. 32:1123-1134
N-linked glycosylation is of key importance for the efficacy of many biotherapeutic proteins such as monoclonal antibodies (mAbs). Media components and cell culture conditions have been shown to significantly affect N-linked glycosylation during the