Zobrazeno 1 - 8 of 8 pro vyhledávání: '"Matthieu Scotto"'
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Zinc transporter (ZnT)8186–194 is an immunodominant CD8+ T cell epitope in HLA-A2+ type 1 diabetic patients
Autor: Matthieu Scotto, Georgia Afonso, Howard W. Davidson, Christian Boitard, John C. Hutton, Danièle Dubois-Laforgue, Odile Launay, Etienne Larger, Cecile Raverdy, Jean-François Gautier, Leonardo Antonio Sechi, Graziella Bruno, B. Baz, Jean-Claude Carel, François Lemonnier, D. Levy, Roberto Mallone
Publikováno v: Diabetologia. 55:2026-2031
Anti-zinc transporter (ZnT)8 autoantibodies are commonly detected in type 1 diabetic patients. We hypothesised that ZnT8 is also recognised by CD8(+) T cells and aimed to identify HLA-A2 (A*02:01)-restricted epitope targets.Candidate epitopes were se
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22a777669e9dd1da9450e69431f8355a
https://doi.org/10.1007/s00125-012-2543-z
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3
Immunology of Diabetes Society T-Cell Workshop: HLA class I tetramer-directed epitope validation initiative T-Cell Workshop Report-HLA Class I Tetramer Validation Initiative
Autor: Matthieu Scotto, Eddie A. James, Christian Boitard, Colin M. Dayan, O. Lou, Nicholas Jospe, Peter A. Gottlieb, Ivana Durinovic-Belló, Rebecca Wagner, Jerill Thorpe, Claire Nicola Janicki, Roberto Mallone, Florence Susan Wong, Lisa Fitzgerald-Miller
Publikováno v: Diabetes/Metabolism Research and Reviews. 27:720-726
BACKGROUND: Identification of T-cell reactivity to β-cell antigen epitopes is an important goal for studying pathogenesis and for designing and monitoring of immunotherapeutic interventions in type 1 diabetes (T1D). METHODS: We performed a multicent
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03b37fd2fbcd35842e05eeb5062c98da
https://doi.org/10.1002/dmrr.1243
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4
Critical parameters in blood processing for T-cell assays: validation on ELISpot and tetramer platforms
Autor: Dominique Vassilieff, Amédée Renand, Matthieu Scotto, Georgia Afonso, Roberto Mallone, Jeanette Arvastsson, Corrado M. Cilio
Publikováno v: Journal of immunological methods. 359(1-2)
Assays detecting antigen (Ag)-specific T-cell responses in immune-mediated processes are increasingly employed to understand disease pathogenesis and immune staging. The quantity and quality of starting peripheral blood mononuclear cell (PBMC) prepar
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b911a986ede19f83c81c07d35abaa0e2
https://pubmed.ncbi.nlm.nih.gov/20641145
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5
Serum-free culture medium and IL-7 costimulation increase the sensitivity of ELISpot detection
Autor: Emanuela Martinuzzi, Matthieu Scotto, Vedran Brezar, Peter van Endert, Jean-Antoine Ribeil, Emmanuelle Énée, Roberto Mallone
Publikováno v: Journal of Immunological Methods
Journal of Immunological Methods, Elsevier, 2008, 333 (1-2), pp.61-70. ⟨10.1016/j.jim.2008.01.003⟩
Journal of Immunological Methods, 2008, 333 (1-2), pp.61-70. ⟨10.1016/j.jim.2008.01.003⟩
Journal of Immunological Methods, Elsevier, 2008, 333 (1-2), pp.61-70. 〈10.1016/j.jim.2008.01.003〉
International audience; The identification of parameters maximizing detection sensitivity in ELISpot assays is important to transfer this technology into the clinical setting for identifying rare Ag-specific CD8(+) T cells. We have therefore consider
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd475967cdd36efbf7ec5501a73b46f5
https://www.hal.inserm.fr/inserm-00266553/file/JIMrevisedFinalLight.pdf
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6
The frequency and immunodominance of islet-specific CD8(+) T-cell responses change after type 1 diabetes diagnosis and treatment
Autor: Jean-Marie Bach, Lucienne Chatenoud, Emanuela Martinuzzi, Peter van Endert, Graziella Bruno, Philippe Blancou, Matthieu Scotto, Roberto Mallone, Lucy Chaillous, Giulia Novelli
Publikováno v: Inconnu
Inconnu, 2008, pp.Inconnu
9. International Congress of the Immunology-of-Diabeties-Society/American-Diabeties-Association-Research Symposium
9. International Congress of the Immunology-of-Diabeties-Society/American-Diabeties-Association-Research Symposium, Nov 2007, Miami Beach, United States. ⟨10.2337/db07-1594⟩
OBJECTIVE—Islet-reactive CD8+ T-cells play a key role in the pathogenesis of type 1 diabetes in the NOD mouse. The predominant T-cell specificities change over time, but whether similar shifts also occur after clinical diagnosis and insulin treatme
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::295cbb07fd34d96a3d196164ec33467b
https://hal.inrae.fr/hal-02818649
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