Zobrazeno 1 - 10
of 239
pro vyhledávání: '"Matthieu Piel"'
Autor:
Fabrizio A. Pennacchio, Alessandro Poli, Francesca Michela Pramotton, Stefania Lavore, Ilaria Rancati, Mario Cinquanta, Daan Vorselen, Elisabetta Prina, Orso Maria Romano, Aldo Ferrari, Matthieu Piel, Marco Cosentino Lagomarsino, Paolo Maiuri
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-10 (2024)
Abstract In eukaryotes, cytoplasmic and nuclear volumes are tightly regulated to ensure proper cell homeostasis. However, current methods to measure cytoplasmic and nuclear volumes, including confocal 3D reconstruction, have limitations, such as rely
Externí odkaz:
https://doaj.org/article/28d7b0b6342e4134aecf5e7c110002be
Autor:
Camille Morel, Eline Lemerle, Feng-Ching Tsai, Thomas Obadia, Nishit Srivastava, Maud Marechal, Audrey Salles, Marvin Albert, Caroline Stefani, Yvonne Benito, François Vandenesch, Christophe Lamaze, Stéphane Vassilopoulos, Matthieu Piel, Patricia Bassereau, David Gonzalez-Rodriguez, Cecile Leduc, Emmanuel Lemichez
Publikováno v:
eLife, Vol 12 (2024)
Large transcellular pores elicited by bacterial mono-ADP-ribosyltransferase (mART) exotoxins inhibiting the small RhoA GTPase compromise the endothelial barrier. Recent advances in biophysical modeling point toward membrane tension and bending rigidi
Externí odkaz:
https://doaj.org/article/28c0af341ffb43cfae9b133c85d5de56
Autor:
Larisa Venkova, Amit Singh Vishen, Sergio Lembo, Nishit Srivastava, Baptiste Duchamp, Artur Ruppel, Alice Williart, Stéphane Vassilopoulos, Alexandre Deslys, Juan Manuel Garcia Arcos, Alba Diz-Muñoz, Martial Balland, Jean-François Joanny, Damien Cuvelier, Pierre Sens, Matthieu Piel
Publikováno v:
eLife, Vol 11 (2022)
Mechanics has been a central focus of physical biology in the past decade. In comparison, how cells manage their size is less understood. Here, we show that a parameter central to both the physics and the physiology of the cell, its volume, depends o
Externí odkaz:
https://doaj.org/article/00751fd3fe314c16a93a136c8a149b52
Autor:
Gururaj Rao Kidiyoor, Qingsen Li, Giulia Bastianello, Christopher Bruhn, Irene Giovannetti, Adhil Mohamood, Galina V. Beznoussenko, Alexandre Mironov, Matthew Raab, Matthieu Piel, Umberto Restuccia, Vittoria Matafora, Angela Bachi, Sara Barozzi, Dario Parazzoli, Emanuela Frittoli, Andrea Palamidessi, Tito Panciera, Stefano Piccolo, Giorgio Scita, Paolo Maiuri, Kristina M. Havas, Zhong-Wei Zhou, Amit Kumar, Jiri Bartek, Zhao-Qi Wang, Marco Foiani
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
The nucleus is a mechanically stiff organelle of the cell and the DNA damage response protein ATR can localize to the nuclear envelope upon mechanical stress. Here, the authors show that ATR may contribute to the integrity of the nuclear envelope and
Externí odkaz:
https://doaj.org/article/ef3b7523ea5c4ef99f9147b73d2702d2
Autor:
Martina Bonucci, Nicolas Kuperwasser, Serena Barbe, Vonda Koka, Delphine de Villeneuve, Chi Zhang, Nishit Srivastava, Xiaoying Jia, Matthew P. Stokes, Frank Bienaimé, Virginie Verkarre, Jean Baptiste Lopez, Fanny Jaulin, Marco Pontoglio, Fabiola Terzi, Benedicte Delaval, Matthieu Piel, Mario Pende
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-17 (2020)
mTOR activation is known to generate polycystic kidneys, which show both increased proliferation and loss of oriented cell division (OCD). Here, Bonucci et al. show that loss of OCD is linked to S6K1 activation through its direct target Afadin and is
Externí odkaz:
https://doaj.org/article/7932503fbce7452fbc9e9d545274ef7a
Publikováno v:
eLife, Vol 11 (2022)
The way proliferating animal cells coordinate the growth of their mass, volume, and other relevant size parameters is a long-standing question in biology. Studies focusing on cell mass have identified patterns of mass growth as a function of time and
Externí odkaz:
https://doaj.org/article/8ddcee0b4cab48c8936a2e7588a6eccb
Autor:
Anvita Bhargava, Alice Williart, Mathieu Maurin, Patricia M. Davidson, Mabel Jouve, Matthieu Piel, Xavier Lahaye, Nicolas Manel
Publikováno v:
Cell Reports, Vol 36, Iss 13, Pp 109763- (2021)
Summary: The human immunodeficiency virus (HIV) enters the nucleus to establish infection, but the role of nuclear envelope proteins in this process is incompletely understood. Inner nuclear transmembrane proteins SUN1 and SUN2 connect nuclear lamins
Externí odkaz:
https://doaj.org/article/2ca985a165d64913ba844e51aa4a9699
Publikováno v:
PLoS Computational Biology, Vol 17, Iss 5, p e1008592 (2021)
During cell migration in confinement, the nucleus has to deform for a cell to pass through small constrictions. Such nuclear deformations require significant forces. A direct experimental measure of the deformation force field is extremely challengin
Externí odkaz:
https://doaj.org/article/a52729305d284b49a973aedc75ce8851
Autor:
Arthur Charles-Orszag, Feng-Ching Tsai, Daria Bonazzi, Valeria Manriquez, Martin Sachse, Adeline Mallet, Audrey Salles, Keira Melican, Ralitza Staneva, Aurélie Bertin, Corinne Millien, Sylvie Goussard, Pierre Lafaye, Spencer Shorte, Matthieu Piel, Jacomine Krijnse-Locker, Françoise Brochard-Wyart, Patricia Bassereau, Guillaume Duménil
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
Meningococci remodel the plasma membrane of host cells during infection. Here, Charles-Orszag et al. show that plasma membrane remodeling occurs independently of F-actin, along meningococcal type IV pili fibers, by a physical mechanism that they term
Externí odkaz:
https://doaj.org/article/a3ee3d2a3841419284f54580f2ed54ad
Autor:
Clotilde Cadart, Sylvain Monnier, Jacopo Grilli, Pablo J. Sáez, Nishit Srivastava, Rafaele Attia, Emmanuel Terriac, Buzz Baum, Marco Cosentino-Lagomarsino, Matthieu Piel
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-15 (2018)
The size of cells fluctuates but there are limited experimental methods to measure live mammalian cell sizes. Here, the authors track single cell volume (FXm) over the cell cycle and generate a mathematical framework to compare size homeostasis in da
Externí odkaz:
https://doaj.org/article/b382a9086db94f9d839660b1465b4b84