Application of fourier transform and proteochemometrics principles to protein engineering

Autor: Frédéric Cadet, Nicolas Fontaine, Iyanar Vetrivel, Matthieu Ng Fuk Chong, Olivier Savriama, Xavier Cadet, Philippe Charton

Publikováno v: BMC Bioinformatics, Vol 19, Iss 1, Pp 1-11 (2018)

Abstract Background Connecting the dots between the protein sequence and its function is of fundamental interest for protein engineers. In-silico methods are useful in this quest especially when structural information is not available. In this study

Externí odkaz: https://doaj.org/article/18efb2f9e4194a9f9d1cccdebc9843b8

Machine Learning Enables Selection of Epistatic Enzyme Mutants for Stability Against Unfolding and Detrimental Aggregation

Autor: Xavier F. Cadet, Nicolas Fontaine, Frédéric Cadet, Youcai Qin, Ferran Feixas, Manfred T. Reetz, Matthieu Ng Fuk Chong, Rudy Pandjaitan, Miguel A. Maria-Solano, Marc Garcia-Borràs, Guangyue Li

Publikováno v: Chembiochem

Machine learning (ML) has pervaded most areas of protein engineering, including stability and stereoselectivity. Using limonene epoxide hydrolase as the model enzyme and innov'SAR as the ML platform, comprising a digital signal process, we achieved h

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77a4a152d679f5c2fc79c6e6449c53ee
http://europepmc.org/articles/PMC7984044

New insights into GluT1 mechanics during glucose transfer

Autor: Tatiana Galochkina, Catherine Etchebest, Sonia Abbar, Lylia Challali, Matthieu Ng Fuk Chong

Publikováno v: Scientific Reports, Vol 9, Iss 1, Pp 1-14 (2019)
Scientific Reports
Scientific Reports, Nature Publishing Group, 2019, 9 (1), pp.998. ⟨10.1038/s41598-018-37367-z⟩

Glucose plays a crucial role in the mammalian cell metabolism. In the erythrocytes and endothelial cells of the blood-brain barrier, glucose uptake is mediated by the glucose transporter type 1 (GluT1). GluT1 deficiency or mutations cause severe phys

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6df14d8b99f4438fa09a23e4ce4d2f40
https://doi.org/10.1038/s41598-018-37367-z

Comparative Genomics of Odorant Binding Proteins in Anopheles gambiae, Aedes aegypti, and Culex quinquefasciatus

Autor: Matthieu Ng Fuk Chong, Aurore Vaitinadapoule, Etienne Frumence, Malini Manoharan, Bernard Offmann, Ramanathan Sowdhamini

Publikováno v: Genome Biology and Evolution

About 1 million people in the world die each year from diseases spread by mosquitoes, and understanding the mechanism of host identification by the mosquitoes through olfaction is at stake. The role of odorant binding proteins (OBPs) in the primary m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::703baeb69e1d8b2c44b8648279b0650b
https://doi.org/10.1093/gbe/evs131