Fast drosophila enterocyte regrowth after infection involves a reverse metabolic flux driven by an amino acid transporter

Autor: Catherine Socha, Inês S. Pais, Kwang-Zin Lee, Jiyong Liu, Samuel Liégeois, Matthieu Lestradet, Dominique Ferrandon

Publikováno v: iScience, Vol 26, Iss 9, Pp 107490- (2023)

Summary: Upon exposure to a bacterial pore-forming toxin, enterocytes rapidly purge their apical cytoplasm into the gut lumen, resulting in a thin intestinal epithelium. The enterocytes regain their original shape and thickness within 16 h after the

Externí odkaz: https://doaj.org/article/7c7085756ff248a18d57aefcd570967f

A prior exposure to Serratia marcescens or xenobiotics primes Drosophila enterocytes against a recurring cytoplasmic purge

Autor: Stefanie Schirmeier, Dominique Ferrandon, Kwang-Zin Lee, Ines Silva Pais, Simone Terreri, Catherine Socha, Bechara Sina-Rahme, Wennida Miriam Yamba, Matthieu Lestradet

The cytoplasmic extrusion of enterocytes is a fast response to an exposure to pore-forming toxin (PFT)-producing bacteria whereby their apical cytoplasm is extruded into the intestinal lumen. As a result of this purge, the intestinal epithelium becom

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::bf01a41056058152d6edbb8d879a1bdd
https://doi.org/10.1101/2021.10.31.466690

The fliR gene contributes to the virulence of S. marcescens in a Drosophila intestinal infection model

Autor: Arshad Ayyaz, Matthieu Lestradet, Bechara Sina Rahme, Gisela Di Venanzio, Eleonora García Véscovi, Miriam Wennida Yamba, Dominique Ferrandon, Martina Lazzaro

Serratia marcescens is an opportunistic bacterium that infects a wide range of hosts including humans. It is a potent pathogen in a septic injury model of Drosophila melanogaster as five bacteria directly injected in the body cavity of the fly kill t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d29bd061978526c8fffb1a79bad432c1
https://doi.org/10.21203/rs.3.rs-831030/v1

Enterocyte Purge and Rapid Recovery Is a Resilience Reaction of the Gut Epithelium to Pore-Forming Toxin Attack

Autor: Céline Keime, Kwang-Zin Lee, Stefanie Schirmeier, Dominique Ferrandon, Wennida Miriam Yamba, Caroline Spenlé, Yannick Schwab, Samuel Liégeois, Frédéric Dalle, Matthieu Lestradet, Catherine Socha, Olivier Lefebvre, Richard Bou Aoun, Patricia Simon-Assmann, Antonin Schmitz

Publikováno v: Cell Host and Microbe
Cell Host and Microbe, Elsevier, 2016, 20 (6), pp.716-730. ⟨10.1016/j.chom.2016.10.010⟩
Cell host & microbe
Cell host & microbe, 2016, 20 (6), pp.716-730. 〈10.1016/j.chom.2016.10.010〉

International audience; Besides digesting nutrients, the gut protects the host against invasion by pathogens. Enterocytes may be subjected to damage by both microbial and host defensive responses, causing their death. Here, we report a rapid epitheli

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::72fc2b8fa98cda50b1d518c7b3014942
https://pubmed.ncbi.nlm.nih.gov/27889464

Drosophila as a Model for Intestinal Infections

Autor: Dominique Ferrandon, Matthieu Lestradet, Kwang-Zin Lee

Publikováno v: Host-Bacteria Interactions ISBN: 9781493912605

Drosophila melanogaster is a powerful model to study infections thanks to the power of its genetics and knowledge on its biology accumulated for over a century. While the systemic humoral immune response against invading microbes has been intensively

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0dfbe1b011c6b82ff0381c12bd1092aa
https://doi.org/10.1007/978-1-4939-1261-2_2