Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Matthieu K, Chardon"'
Autor:
Matthieu K Chardon, Y Curtis Wang, Marta Garcia, Emre Besler, J Andrew Beauchamp, Michael D'Mello, Randall K Powers, Charles J Heckman
Publikováno v:
eLife, Vol 12 (2024)
In this study, we develop new reverse engineering (RE) techniques to identify the organization of the synaptic inputs generating firing patterns of populations of neurons. We tested these techniques in silico to allow rigorous evaluation of their eff
Externí odkaz:
https://doaj.org/article/dca4fd6afd794d27ba7331811bbcf343
Autor:
Y. Curtis Wang, Johann Rudi, James Velasco, Nirvik Sinha, Gideon Idumah, Randall K. Powers, Charles J. Heckman, Matthieu K. Chardon
Publikováno v:
Frontiers in Systems Neuroscience, Vol 16 (2022)
One of the most common types of models that helps us to understand neuron behavior is based on the Hodgkin–Huxley ion channel formulation (HH model). A major challenge with inferring parameters in HH models is non-uniqueness: many different sets of
Externí odkaz:
https://doaj.org/article/417440fe1d7046dc918dcf36357d01c9
Publikováno v:
Journal of NeuroEngineering and Rehabilitation, Vol 16, Iss 1, Pp 1-10 (2019)
Abstract Background Spasticity, characterized by hyperreflexia, is a motor impairment that can arise following a hemispheric stroke. While the neural mechanisms underlying spasticity in chronic stroke survivors are unknown, one probable cause of hype
Externí odkaz:
https://doaj.org/article/56fa8695b9af4a8bbd28d156e7c328ba
Autor:
Matthieu K. Chardon, Y. Curtis Wang, Marta Garcia, Emre Besler, J. Andrew Beauchamp, Michael D’Mello, Randall K. Powers, Charles J. Heckman
In this study, we achieved a major step forward in the analysis of firing patterns of populations of motoneurons, through remarkably extensive parameter searches enabled by massively-parallel computation on supercomputers. The ability to implement th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3884b8a11f79f24a8d7d63aa59784450
https://doi.org/10.1101/2022.12.09.519818
https://doi.org/10.1101/2022.12.09.519818
Autor:
Y. Curtis Wang, Johann Rudi, James Velasco, Nirvik Sinha, Gideon Idumah, Randall K. Powers, Charles J. Heckman, Matthieu K. Chardon
One of the most common types of models that helps us to understand neuron behavior is based on the Hodgkin–Huxley ion channel formulation (HH model). A major challenge with inferring parameters in HH models is non-uniqueness: many different sets of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a787551bbcb6f3eec140b593853a0e57
https://hdl.handle.net/10919/112831
https://hdl.handle.net/10919/112831
Autor:
Obaid U, Khurram, Gregory E P, Pearcey, Matthieu K, Chardon, Edward H, Kim, Marta, García, C J, Heckman
Publikováno v:
Advances in neurobiology. 28
Motor units, which comprise a motoneuron and the set of muscle fibers it innervates, are the fundamental neuromuscular transducers for all motor commands. The one to one relationship between a motoneuron and its innervated muscle fibers allow motoneu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::e324662ba7c87f2b0ef5456aaffb116e
https://pubmed.ncbi.nlm.nih.gov/36066828
https://pubmed.ncbi.nlm.nih.gov/36066828
Autor:
Obaid U. Khurram, Gregory E. P. Pearcey, Matthieu K. Chardon, Edward H. Kim, Marta García, C. J. Heckman
Publikováno v:
Advances in Neurobiology ISBN: 9783031071669
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a8cdcf2004f892bb8994243f57f7ea49
https://doi.org/10.1007/978-3-031-07167-6_10
https://doi.org/10.1007/978-3-031-07167-6_10
Autor:
Charles J. Heckman, Johann Rudi, Gideon Idumah, Y. Curtis Wang, Randall K. Powers, James Velasco, Nirvik Sinha, Matthieu K. Chardon
Experimental data-based parameter search for Hodgkin–Huxley-style (HH) neuron models is a major challenge for neuroscientists and neuroengineers. Current search strategies are often computationally expensive, are slow to converge, have difficulty h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2488ebd769c99d348fe32f41d7021034
https://doi.org/10.1101/2021.11.18.469189
https://doi.org/10.1101/2021.11.18.469189
Publikováno v:
IEEE Trans Neural Syst Rehabil Eng
We characterized the passive mechanical properties of the affected and contralateral musculotendon units in 9 chronic stroke survivors as well as in 6 neurologically-intact controls. Using a position-controlled motor, we precisely indented the distal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::104782683c4e423a8c9de18fa393190f
https://pubmed.ncbi.nlm.nih.gov/32149642
https://pubmed.ncbi.nlm.nih.gov/32149642
Publikováno v:
Journal of NeuroEngineering and Rehabilitation
Journal of NeuroEngineering and Rehabilitation, Vol 16, Iss 1, Pp 1-10 (2019)
Journal of NeuroEngineering and Rehabilitation, Vol 16, Iss 1, Pp 1-10 (2019)
Background Spasticity, characterized by hyperreflexia, is a motor impairment that can arise following a hemispheric stroke. While the neural mechanisms underlying spasticity in chronic stroke survivors are unknown, one probable cause of hyperreflexia
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::50c836cc5619458f10334ceb3c661d8c
https://pubmed.ncbi.nlm.nih.gov/31806032
https://pubmed.ncbi.nlm.nih.gov/31806032