Zobrazeno 1 - 10
of 35
pro vyhledávání: '"Matthieu J. R. Richter"'
Autor:
Liam Hudson, Jeremy W. Mason, Matthias V. Westphal, Matthieu J. R. Richter, Jonathan R. Thielman, Bruce K. Hua, Christopher J. Gerry, Guoqin Xia, Heather L. Osswald, John M. Knapp, Zher Yin Tan, Praveen Kokkonda, Ben I. C. Tresco, Shuang Liu, Andrew G. Reidenbach, Katherine S. Lim, Jennifer Poirier, John Capece, Simone Bonazzi, Christian M. Gampe, Nichola J. Smith, James E. Bradner, Connor W. Coley, Paul A. Clemons, Bruno Melillo, C. Suk-Yee Hon, Johannes Ottl, Christoph E. Dumelin, Jonas V. Schaefer, Ann Marie E. Faust, Frédéric Berst, Stuart L. Schreiber, Frédéric J. Zécri, Karin Briner
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-15 (2023)
Abstract Diversity-oriented synthesis (DOS) is a powerful strategy to prepare molecules with underrepresented features in commercial screening collections, resulting in the elucidation of novel biological mechanisms. In parallel to the development of
Externí odkaz:
https://doaj.org/article/36c9d05209eb47b1b03cc9fce00df87d
Autor:
Liam Hudson, Jeremy W. Mason, Matthias V. Westphal, Matthieu J. R. Richter, Jonathan R. Thielman, Bruce K. Hua, Christopher J. Gerry, Guoqin Xia, Heather L. Osswald, John M. Knapp, Zher Yin Tan, Praveen Kokkonda, Ben I. C. Tresco, Shuang Liu, Andrew G. Reidenbach, Katherine S. Lim, Jennifer Poirier, John Capece, Simone Bonazzi, Christian M. Gampe, Nichola J. Smith, James E. Bradner, Connor W. Coley, Paul A. Clemons, Bruno Melillo, C. Suk-Yee Hon, Johannes Ottl, Christoph E. Dumelin, Jonas V. Schaefer, Ann Marie E. Faust, Frédéric Berst, Stuart L. Schreiber, Frédéric J. Zécri, Karin Briner
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-1 (2023)
Externí odkaz:
https://doaj.org/article/d2f9e92baa034e31a3064fe3179e5c22
Autor:
Liam Hudson, Jeremy W. Mason, Matthias V. Westphal, Matthieu J. R. Richter, Jonathan R. Thielman, Bruce K. Hua, Christopher J. Gerry, Guoqin Xia, Heather L. Osswald, John M. Knapp, Zher Yin Tan, Praveen Kokkonda, Ben I. C. Tresco, Shuang Liu, Andrew G. Reidenbach, Katherine S. Lim, Jennifer Poirier, John Capece, Simone Bonazzi, Christian M. Gampe, Nichola J. Smith, James E. Bradner, Connor W. Coley, Paul A. Clemons, Bruno Melillo, C. Suk-Yee Hon, Johannes Ottl, Christoph E. Dumelin, Jonas V. Schaefer, Ann Marie E. Faust, Frédéric Berst, Stuart L. Schreiber, Frédéric J. Zécri, Karin Briner
Diversity-oriented synthesis (DOS)is a powerful strategy to prepare molecules with underrepresented features in commercial screening collections, resulting in the elucidation of novel biological mechanisms. In parallel to the development of DOS, DNA-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ea89009e90b9f024b527255fb7155d39
https://doi.org/10.1101/2022.10.16.512431
https://doi.org/10.1101/2022.10.16.512431
Autor:
Karli R. Holman, Allison M. Stanko, Matthieu J. R. Richter, Sean S. Feng, Mahideremariyam N. Gessesse, Sarah E. Reisman
Publikováno v:
Organic letters. 24(16)
Radical and transition metal-catalyzed cascade cyclization strategies were investigated with respect to the synthesis of the tetracyclic core of the augustamine-type Amaryllidaceae alkaloids. These studies resulted in the synthesis of noraugustamine
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2787c9972a37b5c556138fb477d4709f
https://pubmed.ncbi.nlm.nih.gov/35426682
https://pubmed.ncbi.nlm.nih.gov/35426682
Publikováno v:
Angewandte Chemie (International ed. in English). 61(38)
Cyclopropane-fused N-heterocycles are featured in various biologically active compounds and represent attractive scaffolds in medicinal chemistry. However, synthesis routes to access structurally and functionally diverse cyclopropane-fused N-heterocy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2cc7ecf46c5fa276debb8ebb8ee061ee
https://pubmed.ncbi.nlm.nih.gov/35395129
https://pubmed.ncbi.nlm.nih.gov/35395129
Publikováno v:
Journal of the American Chemical Society
Journal of the American Chemical Society, 142 (41)
Journal of the American Chemical Society, 142 (41)
A highly enantioselective and diastereoselective total synthesis of the diterpenoid (−)-mitrephorone A is presented. Key to the synthesis are stereocontrolled 1,4-semihydrogenation of a 1,3-diene to a tetrasubstituted double bond, enzyme-catalyzed
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b48cd814f0bbcf1edf79e7a6ecf7a586
https://doi.org/10.1021/jacs.0c09520
https://doi.org/10.1021/jacs.0c09520
Autor:
Simon Krautwald, Michael Schneider, Erick M. Carreira, Marco Brandstätter, Matthieu J. R. Richter
Publikováno v:
Journal of the American Chemical Society. 143:9694-9694
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::67ea88258d9b00c5d82466f60a781310
https://doi.org/10.1021/jacs.1c05408
https://doi.org/10.1021/jacs.1c05408
Publikováno v:
Organic letters. 21(21)
Enantioselective synthesis of a highly versatile building block en route to trachylobanes and related terpenoids is presented. The synthesis features diastereoselective Diels-Alder cycloaddition reaction, a cyclopropanation/homoquadricyclane rearrang
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4cd7cbef5caed5949e736d83c9ec1582
https://pubmed.ncbi.nlm.nih.gov/31603687
https://pubmed.ncbi.nlm.nih.gov/31603687
Autor:
Simon Krautwald, Marco Brandstätter, Matthieu J. R. Richter, Michael Schneider, Erick M. Carreira
Publikováno v:
Journal of the American Chemical Society. 140(48)
The first synthesis of (−)-mitrephorone A is disclosed along with discussion and study of synthetic strategies. The natural product includes a highly congested hexacyclic ent-trachylobane diterpenoid framework featuring a rare, embedded oxetane. Th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::65021c6bd8263d6cb290d903f73811d5
https://pubmed.ncbi.nlm.nih.gov/34156866
https://pubmed.ncbi.nlm.nih.gov/34156866
Publikováno v:
Synfacts. 15:1221
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::44db842ce5921fb77a12706179c5b29a
https://doi.org/10.1055/s-0039-1691051
https://doi.org/10.1055/s-0039-1691051