Capsules and their traits shape phage susceptibility and plasmid conjugation efficiency

Autor: Matthieu Haudiquet, Julie Le Bris, Amandine Nucci, Rémy A. Bonnin, Pilar Domingo-Calap, Eduardo P. C. Rocha, Olaya Rendueles

Publikováno v: Nature Communications, Vol 15, Iss 1, Pp 1-16 (2024)

Abstract Bacterial evolution is affected by mobile genetic elements like phages and conjugative plasmids, offering new adaptive traits while incurring fitness costs. Their infection is affected by the bacterial capsule. Yet, its importance has been d

Externí odkaz: https://doaj.org/article/0c0af7fa625a40488ebb88452df90aa0

IntegronFinder 2.0: Identification and Analysis of Integrons across Bacteria, with a Focus on Antibiotic Resistance in Klebsiella

Autor: Bertrand Néron, Eloi Littner, Matthieu Haudiquet, Amandine Perrin, Jean Cury, Eduardo P. C. Rocha

Publikováno v: Microorganisms, Vol 10, Iss 4, p 700 (2022)

Integrons are flexible gene-exchanging platforms that contain multiple cassettes encoding accessory genes whose order is shuffled by a specific integrase. Integrons embedded within mobile genetic elements often contain multiple antibiotic resistance

Externí odkaz: https://doaj.org/article/60d097f8e95e40d780b8b6111baca133

Selfish, promiscuous and sometimes useful: how mobile genetic elements drive horizontal gene transfer in microbial populations

Autor: Matthieu Haudiquet, Jorge Moura de Sousa, Marie Touchon, Eduardo P. C. Rocha

Publikováno v: Philosophical Transactions of the Royal Society of London. B (1887–1895)
Philosophical Transactions of the Royal Society of London. B (1887–1895), 2022, 377 (1861), pp.20210234. ⟨10.1098/rstb.2021.0234⟩

Horizontal gene transfer (HGT) drives microbial adaptation but is often under the control of mobile genetic elements (MGEs) whose interests are not necessarily aligned with those of their hosts. In general, transfer is costly to the donor cell while

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa358293c7dfc48a255395dd62c6250e
https://pubmed.ncbi.nlm.nih.gov/35989606

Modular prophage interactions driven by capsule serotype select for capsule loss under phage predation

Autor: Amandine Buffet, Jorge A. Moura de Sousa, Matthieu Haudiquet, Eduardo P. C. Rocha, Olaya Rendueles

Publikováno v: ISME Journal
ISME Journal, Nature Publishing Group, 2020, 14 (12), pp.2980-2996. ⟨10.1038/s41396-020-0726-z⟩
The ISME Journal
ISME Journal, 2020, 14 (12), pp.2980-2996. ⟨10.1038/s41396-020-0726-z⟩

Klebsiella species are able to colonize a wide range of environments and include worrisome nosocomial pathogens. Here, we sought to determine the abundance and infectivity of prophages of Klebsiella to understand how the interactions between induced

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a62c09091a2900ce0bffb44cc2f2ba79
https://hal-pasteur.archives-ouvertes.fr/pasteur-02991081/document

Selection for the bacterial capsule in the absence of biotic and abiotic aggressions depends on growth conditions

Autor: Olaya Rendueles, Amandine Buffet, Eduardo P. C. Rocha

Extracellular capsules are the outermost layer of some cells and are prevalent across Bacteria. They protect the cell against both abiotic and biotic stresses such as bacteriophages and the host immune system. Yet, it is unclear if capsules contribut

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d3f3826a658f0ae355c671b30fd1e18f
https://hal-pasteur.archives-ouvertes.fr/pasteur-02991089