Výsledky vyhledávání - "Matthieu Gobin"

Akademický článek

A robust protocol for the generation of human midbrain organoids

Autor: Alise Zagare, Matthieu Gobin, Anna S. Monzel, Jens C. Schwamborn

Publikováno v: STAR Protocols, Vol 2, Iss 2, Pp 100524- (2021)

Summary: The lack of advanced in vitro models recapitulating the human brain complexity is still a major obstacle in brain development and neurological disease research. Here, we describe a robust protocol to derive human midbrain organoids from neur

Externí odkaz: https://doaj.org/article/43d9513765aa4cb2815b6ea8540ac9eb

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Supplementary Data 1 from A DNA Repair and Cell-Cycle Gene Expression Signature in Primary and Recurrent Glioblastoma: Prognostic Value and Clinical Implications

Autor: Eric Van Dyck, Simone P. Niclou, Roland Goldbrunner, Christel C. Herold-Mende, Anthony J. Chalmers, Laurent Vallar, Joerg Felsberg, Guido Reifenberger, Marco Timmer, Rolf Warta, Petr V. Nazarov, Matthieu Gobin

This document details the preliminary differential gene expression analysis carried out using the Köln dataset

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a530a8d9ea59fba62d361db0b20be5f
https://doi.org/10.1158/0008-5472.22422992.v1

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Supplementary Data 3 from A DNA Repair and Cell-Cycle Gene Expression Signature in Primary and Recurrent Glioblastoma: Prognostic Value and Clinical Implications

This document contains Supplementary Table S1, which provides the expression data pertaining to the 27-gene signature and relevant clinical data of the Heidelberg cohort.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25467b3bffad6bda160e6d15ebdb4fed
https://doi.org/10.1158/0008-5472.22422986

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Data from A DNA Repair and Cell-Cycle Gene Expression Signature in Primary and Recurrent Glioblastoma: Prognostic Value and Clinical Implications

Inevitable tumor recurrence and a poor median survival are frustrating reminders of the inefficacy of our current standard of care for patients with newly diagnosed glioblastoma (GBM), which includes surgery followed by radiotherapy and chemotherapy

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e12a4404baa3e65038c24a6372f54666
https://doi.org/10.1158/0008-5472.c.6511391.v1

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Supplementary Data 2 from A DNA Repair and Cell-Cycle Gene Expression Signature in Primary and Recurrent Glioblastoma: Prognostic Value and Clinical Implications

This document contains Supplementary Figures S1-S6 as well as their Legends. Specifically, Fig. S1: characterization of the 52 gene signature; Fig. S2: Validation of the 27 DNA repair and cell cycle gene signature; Fig. S3: Analysis of the Murat coho

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5447fb6e0c7fc83360aa25dad83354ae
https://doi.org/10.1158/0008-5472.22422989

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Supplementary Data 5 from A DNA Repair and Cell-Cycle Gene Expression Signature in Primary and Recurrent Glioblastoma: Prognostic Value and Clinical Implications

This document contains Supplementary Table S4, which regroups the differentially expressed genes identified between the G1 and G3 groups of the Wang dataset and the gene ontology terms associated.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::84f7bf2604820960fa6104bab910aec8
https://doi.org/10.1158/0008-5472.22422980

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A DNA Repair and Cell-Cycle Gene Expression Signature in Primary and Recurrent Glioblastoma: Prognostic Value and Clinical Implications

Autor: Roland Goldbrunner, Rolf Warta, Guido Reifenberger, Marco Timmer, Eric Van Dyck, Anthony J. Chalmers, Simone P. Niclou, Christel Herold-Mende, Matthieu Gobin, Joerg Felsberg, Laurent Vallar, Petr V. Nazarov

Publikováno v: Cancer Research. 79:1226-1238

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b5b14d3c46440f2422558df39c3a4023
https://doi.org/10.1158/0008-5472.can-18-2076

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A robust protocol for the generation of human midbrain organoids

Autor: Jens Christian Schwamborn, Matthieu Gobin, Alise Zagare, Anna S. Monzel

Publikováno v: STAR Protocols, Vol 2, Iss 2, Pp 100524-(2021)
STAR Protocols

Summary The lack of advanced in vitro models recapitulating the human brain complexity is still a major obstacle in brain development and neurological disease research. Here, we describe a robust protocol to derive human midbrain organoids from neuro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d6d0441a771bb2bf909348fa88a0ca21
https://doi.org/10.1016/j.xpro.2021.100524

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DNA repair mechanisms and their clinical impact in glioblastoma

Autor: Simone P. Niclou, Matthieu Gobin, Eric Van Dyck, H. Erasimus

Publikováno v: Mutation research. Reviews in mutation research. 769

Despite surgical resection and genotoxic treatment with ionizing radiation and the DNA alkylating agent temozolomide, glioblastoma remains one of the most lethal cancers, due in great part to the action of DNA repair mechanisms that drive resistance

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e10c14e372b1efe855931cbe3aac0981
https://pubmed.ncbi.nlm.nih.gov/27543314

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