Výsledky vyhledávání - "Matthieu Jeanty"

Extending the Scope of the Aza-Fischer Synthesis of 4- and 6-Azaindoles

Autor: David Thomae, Matthieu Jeanty, Franck Suzenet, Gérald Guillaumet, Jerome Coste

Publikováno v: European Journal of Organic Chemistry. 2013:3328-3336

Fischer indole cyclization has recently been described as an efficient approach to the synthesis of azaindoles bearing electron-donating groups. We now show that this cascade reaction can be very efficient for the formation of a wider range of 4- and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::652282c5c6159a4e37fb3cfd17f99c21
https://doi.org/10.1002/ejoc.201300167

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Design and synthesis of 1-(2-alkanamidoethyl)-6-methoxy-7-azaindole derivatives as potent melatonin agonists

Autor: Franck Suzenet, Philippe Delagrange, Matthieu Jeanty, Olivier Nosjean, Jean A. Boutin, Daniel Henri Caignard, Gérald Guillaumet

Publikováno v: Bioorganic & Medicinal Chemistry Letters. 21:2316-2319

A series of 7-azaindolic ligands bearing a methoxy group and a N -acetyl chain as melatoninergic pharmacophores were synthesized and their binding affinities towards MT 1 and MT 2 receptors were evaluated. Compounds 7a – c and 12 (cyclohexyl ring c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f214ad6078d08a6ef7aa59fbba2db2a
https://doi.org/10.1016/j.bmcl.2011.02.097

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Synthesis of 4- and 6-Azaindoles via the Fischer Reaction

Autor: Gérald Guillaumet, Franck Suzenet, Jerome Blu, Matthieu Jeanty

Publikováno v: Organic Letters. 11:5142-5145

Contrary to the common idea that Fischer indole cyclization often cannot be effectively applied to the synthesis of the corresponding azaindoles, we show that this approach can be actually very efficient for the formation of 4- and 6-azaindoles beari

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ea5d327eb4015f007e172f4aef83ad9
https://doi.org/10.1021/ol902139r

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Synthesis of C3-Substituted 4-Azaindoles: An Easy Access to 4-Azamelatonin and Protected 4-Azatryptophan

Autor: Franck Suzenet, Matthieu Jeanty, Gérald Guillaumet

Publikováno v: The Journal of Organic Chemistry. 73:7390-7393

C3-Substituted-4-azaindoles were synthesized from pyridylacetonitriles in a two-step sequence allowing the easy introduction of a range of substituents. This strategy permits the rapid synthesis of 4-azamelatonin and a protected 4-azatryptophan.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8fd8d4e10fba635bbb9071726d910039
https://doi.org/10.1021/jo8011623

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Novel synthetic bis-indolic derivatives with antistaphylococcal activity, including against MRSA and VISA strains

Autor: Claude Jolivalt, Yvan Caspar, Olga Burchak, Dominique Schneider, Frédéric Minassian, Max Maurin, Jean-Noel Denis, Jean-Marc Paris, Matthieu Jeanty, Laure Maigre, Emmanuelle Le Pihive, Jérôme Blu, Arnaud Hequet

Publikováno v: Journal of Antimicrobial Chemotherapy
Journal of Antimicrobial Chemotherapy, Oxford University Press (OUP), In press, ⟨10.1093/jac/dkv015⟩

Objectives We report the synthesis, antibacterial activity and toxicity of 24 bis-indolic derivatives obtained during the development of new ways of synthesis of marine bis-indole alkaloids from the spongotine, topsentin and hamacanthin classes. Meth

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c5dd37ab96e655bb9c66c540aa69856
https://hal.archives-ouvertes.fr/hal-01651392

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1-(1H-Indol-3-yl)ethanamine Derivatives as Potent Staphylococcus aureus NorA Efflux Pump Inhibitors

Autor: Xavier Guinchard, Jean-Noel Denis, Pascale Bouhours, Olga N. Burchak, Arnaud Hequet, Jean-Marc Paris, Dominique Schneider, Claude Jolivalt, Emmanuelle Le Pihive, Laure Maigre, Max Maurin, Matthieu Jeanty

Publikováno v: ChemMedChem
ChemMedChem, Wiley-VCH Verlag, 2014, 9 (7), epub ahead of print. ⟨10.1002/cmdc.201400042⟩
ChemMedChem, Wiley-VCH Verlag, 2014, 9 (7), pp.1534-1545

International audience; : The synthesis of 37 1-(1H-indol-3-yl)ethanamine derivatives, including 12 new compounds, was achieved through a series of simple and efficient chemical modifications. These indole derivatives displayed modest or no intrinsic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb71a10c24e0fc5ea75346904a781155
https://hal.archives-ouvertes.fr/hal-00986364

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ChemInform Abstract: Extending the Scope of the Aza-Fischer Synthesis of 4- and 6-Azaindoles

Autor: David Thomae, Gérald Guillaumet, Matthieu Jeanty, Franck Suzenet, Jerome Coste

Publikováno v: ChemInform. 44

The cascade reaction of the Fischer synthesis can be efficiently applied to the formation of 4- and 6-azaindoles using microwave irradiation.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a321ecd3627b4daea6ce052f507afff0
https://doi.org/10.1002/chin.201345157

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Organocatalytic cascade reactions as a new tool in total synthesis

Autor: Dieter Enders, Christoph Grondal, Matthieu Jeanty

Publikováno v: Nature chemistry. 2(3)

The total synthesis of natural products and biologically active compounds, such as pharmaceuticals and agrochemicals, has reached an extraordinary level of sophistication. We are, however, still far away from the 'ideal synthesis' and the state of th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af099f45c1e4f474d027b4ce0801b5a7
https://pubmed.ncbi.nlm.nih.gov/21124474

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ChemInform Abstract: Organocatalytic Cascade Reactions as a New Tool in Total Synthesis

Autor: Matthieu Jeanty, Christoph Grondal, Dieter Enders

Publikováno v: ChemInform. 41

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ce83956b0d9c4f04843085ab49d8752a
https://doi.org/10.1002/chin.201028231

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