Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Matthias Winzer"'
Autor:
Jared Snell, Bernhard Valldorf, Florian Johann, Henning Gieseler, Steffen Wöll, Matthias Winzer
Publikováno v:
Journal of pharmaceutical sciences. 111(5)
Microplate-based formulation screening is a powerful approach to identify stabilizing excipients for therapeutic proteins while reducing material requirements. However, this approach is sometimes not representative of studies conducted in relevant co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f03d63993a433d7bbf927bf1267211ef
https://pubmed.ncbi.nlm.nih.gov/34563536
https://pubmed.ncbi.nlm.nih.gov/34563536
Publikováno v:
Molecular Pharmaceutics. 15:2656-2664
In silico screening of toxin payloads typically employed in ADCs revealed a wide range of hydrophobicities and sizes as measured by log P and topological polar surface area (tPSA) values. These descriptors were used to identify three nontoxic surroga
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d1cc5ffc8443a43ce7df52afb004c22e
https://doi.org/10.1021/acs.molpharmaceut.8b00177
https://doi.org/10.1021/acs.molpharmaceut.8b00177
Publikováno v:
Journal of Pharmacy and Pharmacology. 70:636-647
Objective Solubility is often one of the limiting factors for high-concentration protein formulation (HCF) development. Determination of protein solubility is challenging and requires high amount of material. Therefore, low-volume and predictive appr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a56e8544abdf34109d17788435b9c7a2
https://doi.org/10.1111/jphp.12621
https://doi.org/10.1111/jphp.12621
Publikováno v:
Journal of Pharmaceutical Sciences. 105:1819-1828
The development of highly concentrated protein formulations is more demanding than for conventional concentrations due to an elevated protein aggregation tendency. Predictive protein-protein interaction parameters, such as the second virial coefficie
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d95f295b64802b03666c37c83f237109
https://doi.org/10.1016/j.xphs.2016.03.022
https://doi.org/10.1016/j.xphs.2016.03.022
Publikováno v:
Journal of pharmaceutical sciences. 108(3)
Oxidation of biopharmaceutics represents a major degradation pathway, which may impact bioactivity, serum half-life, and colloidal stability. This study focused on the quantification of oxidation and its effects on structure and colloidal stability f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9cd83580112b87051c57654c1cf01856
https://pubmed.ncbi.nlm.nih.gov/30389566
https://pubmed.ncbi.nlm.nih.gov/30389566
Publikováno v:
The Journal of pharmacy and pharmacology. 70(5)
Objectives Oxidation of protein therapeutics is a major chemical degradation pathway which may impact bioactivity, serum half-life and stability. Therefore, oxidation is a relevant parameter which has to be monitored throughout formulation developmen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::750d3a05bb8f9bddfe03a9ee8f4c231f
https://pubmed.ncbi.nlm.nih.gov/29380379
https://pubmed.ncbi.nlm.nih.gov/29380379
Publikováno v:
The Journal of pharmacy and pharmacology. 70(5)
Objective Polyethylene glycol (PEG)-induced protein precipitation is often used to extrapolate apparent protein solubility at specific formulation compositions. The procedure was used for several fields of application such as protein crystal growth b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0261823d9f20a13393a6114b636e4723
https://pubmed.ncbi.nlm.nih.gov/28106257
https://pubmed.ncbi.nlm.nih.gov/28106257