Integrate mechanistic evidence from new approach methodologies (NAMs) into a read-across assessment to characterise trends in shared mode of action

Autor: Alejandro Aguayo-Orozco, Liliana Capinha, Nazanin Golbamaki, Enrico Mombelli, Matthias Wehr, Bart van der Burg, Daria Goldmann, Nanette G Vrijenhoek, Thomas Exner, Richard Maclennan, Katharina Brotzmann, Ulf Norinder, Oliver Hatley, Alice Limonciel, Thomas Braunbeck, Sylvia Escher, Barbara Zdrazil, Frédéric Y. Bois, Paul Jennings, Emilio Benfenati, Domenico Gadaleta, Jose Castel, Ciarán Fisher, Sankalp Jain, Anthony Long, Rabea Graepel, Laia Tolosa, Andrew White, Bob van de Water, Barbara M.A. van Vugt-Lussenburg, Paul Walker, Annette Bitsch, Olivier Taboureau, Iain Gardner

Publikováno v: Toxicology in Vitro, 79:105269, 1-16. Elsevier Limited
Escher, S E, Aguayo-Orozco, A, Benfenati, E, Bitsch, A, Braunbeck, T, Brotzmann, K, Bois, F, van der Burg, B, Castel, J, Exner, T, Gadaleta, D, Gardner, I, Goldmann, D, Hatley, O, Golbamaki, N, Graepel, R, Jennings, P, Limonciel, A, Long, A, Maclennan, R, Mombelli, E, Norinder, U, Jain, S, Capinha, L S, Taboureau, O T, Tolosa, L, Vrijenhoek, N G, van Vugt-Lussenburg, B M A, Walker, P, van de Water, B, Wehr, M, White, A, Zdrazil, B & Fisher, C 2022, ' Integrate mechanistic evidence from new approach methodologies (NAMs) into a read-across assessment to characterise trends in shared mode of action ', Toxicology in Vitro, vol. 79, 105269, pp. 1-16 . https://doi.org/10.1016/j.tiv.2021.105269
Escher, S E, Aguayo-Orozco, A, Benfenati, E, Bitsch, A, Braunbeck, T, Brotzmann, K, Bois, F, van der Burg, B, Castel, J, Exner, T, Gadaleta, D, Gardner, I, Goldmann, D, Hatley, O, Golbamaki, N, Graepel, R, Jennings, P, Limonciel, A, Long, A, Maclennan, R, Mombelli, E, Norinder, U, Jain, S, Capinha, L S, Taboureau, O T, Tolosa, L, Vrijenhoek, N G, van Vugt-Lussenburg, B M A, Walker, P, van de Water, B, Wehr, M, White, A, Zdrazil, B & Fisher, C 2022, ' Integrate mechanistic evidence from new approach methodologies (NAMs) into a read-across assessment to characterise trends in shared mode of action ', Toxicology in Vitro, vol. 79, 105269 . https://doi.org/10.1016/j.tiv.2021.105269
Toxicology in Vitro
Toxicology In Vitro, 79

Read-across approaches often remain inconclusive as they do not provide sufficient evidence on a common mode of action across the category members. This read-across case study on thirteen, structurally similar, branched aliphatic carboxylic acids inv

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f590a32abedab5573e9153a784e9f86c
https://pubmed.ncbi.nlm.nih.gov/34757180

Model Predictive Control of an Overactuated Roll Gap with a Moving Manipulated Variable

Autor: Gerhard Hirt, Sven Schätzler, Matthias Wehr, Dirk Abel

Publikováno v: ACC

Model predictive control (MPC) has been used in a variety of industrial processes. Due to its large computation time application to fast and complex processes is limited. Therefore, reducing complexity has been focus of intense research. In this pape

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::939595fc2456b154c5df9210e6374195
https://doi.org/10.23919/acc45564.2020.9147360

Improving the thickness accuracy of cold rolled narrow strip by piezoelectric roll gap control at high rolling speed

Autor: Sven Stockert, Matthias Wehr, Gerhard Hirt, Johannes Lohmar, Dirk Abel

Publikováno v: CIRP Annals. 67:313-316

Particularly in fast rolling mills, conventional actuators reach their dynamic limits, when longitudinal thickness variations of the incoming strip shall be reduced with high accuracy by model-predictive roll gap control. Accordingly, the applicabili

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::011d30e7b68cc11e9d019627d4bc4f6a
https://doi.org/10.1016/j.cirp.2018.04.107

The IRT-Buggy – Vehicle Platform for Research and Education

Autor: Robin Taborsky, Andreas Trzuskowsky, Matthias Reiter, Dirk Abel, Matthias Wehr, Florian Sehr

Publikováno v: IFAC-PapersOnLine. 50:12588-12595

This paper presents the “IRT-Buggy”, a model vehicle that is designed as a platform for research and education and that is developed at RWTH Aachen University. With two steered front wheels and two powered rear wheels, it can reach speeds of appr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::bdbed60376e1fd73a6cfe2ebf7de503b
https://doi.org/10.1016/j.ifacol.2017.08.2200

Inzidente Normverwerfung durch die Exekutive. : Zum kompetentiellen Verhältnis von Normsetzung und Normanwendung.

Autor: Matthias Wehr

Die Frage, wie sich die öffentliche Verwaltung gegenüber einer von ihr als rechtswidrig angesehenen Norm verhalten soll, gehört zu den bislang noch ungeklärten Grundfragen des Verwaltungsrechts, die vor dem Hintergrund der Rechtsprechung des Euro