Zobrazeno 1 - 10
of 98
pro vyhledávání: '"Matthias Watzka"'
Autor:
Katrin J. Czogalla, Kerstin Liphardt, Klara Höning, Veit Hornung, Arijit Biswas, Matthias Watzka, Johannes Oldenburg
Publikováno v:
Blood Advances, Vol 2, Iss 6, Pp 691-702 (2018)
Abstract: Vitamin K reduction is catalyzed by 2 enzymes in vitro: the vitamin K 2,3-epoxide reductase complex subunit 1 (VKORC1) and its isozyme VKORC1-like1 (VKORC1L1). In vivo, VKORC1 reduces vitamin K to sustain γ-carboxylation of vitamin K-depen
Externí odkaz:
https://doaj.org/article/f4c0d6d5c29042b79cd901c0209c7844
Autor:
Veit Hornung, Heike Singer, Klara Höning, Katrin J. Czogalla-Nitsche, Katrin Kraus, S Ghosh, Arijit Biswas, Johannes Oldenburg, Jens Müller, Francesco Forin, Matthias Watzka
Publikováno v:
Human Mutation. 43:42-55
γ-Glutamyl carboxylase (GGCX) catalyses γ-carboxylation of 15 different vitamin K dependent (VKD) proteins. Pathogenic variants in GGCX cause a rare hereditary bleeding disorder called Vitamin K dependent coagulation factor deficiency type 1 (VKCFD
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9cceeac0a9f39124f715e07f7697cef4
https://doi.org/10.1002/humu.24300
https://doi.org/10.1002/humu.24300
Publikováno v:
Nutrients, Vol 7, Iss 8, Pp 6837-6851 (2015)
Vitamin K 2,3-epoxide reductase complex subunit 1 (VKORC1) catalyses the reduction of vitamin K and its 2,3-epoxide essential to sustain γ-carboxylation of vitamin K-dependent proteins. Two different phenotypes are associated with mutations in human
Externí odkaz:
https://doaj.org/article/4c8378bb360f4b4686acc073862f0eba
Publikováno v:
Nutrients, Vol 7, Iss 8, Pp 6250-6280 (2015)
Among all cellular life on earth, with the exception of yeasts, fungi, and some prokaryotes, VKOR family homologs are ubiquitously encoded in nuclear genomes, suggesting ancient and important biological roles for these enzymes. Despite single gene an
Externí odkaz:
https://doaj.org/article/819a8c330bca4a9680b31f3dc165daf0
Autor:
Carville G. Bevans, Christoph Krettler, Christoph Reinhart, Matthias Watzka, Johannes Oldenburg
Publikováno v:
Nutrients, Vol 7, Iss 8, Pp 6224-6249 (2015)
In humans and other vertebrate animals, vitamin K 2,3-epoxide reductase (VKOR) family enzymes are the gatekeepers between nutritionally acquired K vitamins and the vitamin K cycle responsible for posttranslational modifications that confer biological
Externí odkaz:
https://doaj.org/article/7adfc3e3a5cf400faf52de5466b7b37b
Autor:
Katrin Kraus, Arijit Biswas, Francesco Forin, Jens Müller, Heike Singer, Anna-Lena Buhl, Matthias Watzka, Johannes Oldenburg, S Ghosh, Klara Höning, Veit Hornung, Katrin J. Czogalla-Nitsche
Publikováno v:
Journal of Thrombosis and Haemostasis. 19:1412-1424
Background Vitamin K dependent coagulation factor deficiency type 1 (VKCFD1) is a rare hereditary bleeding disorder caused by mutations in γ-Glutamyl carboxylase (GGCX). VKCFD1 patients are treated life-long with high doses of vitamin K in order to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a8bc23c36c9fff37747e8b6d2da5fbeb
https://doi.org/10.1111/jth.15238
https://doi.org/10.1111/jth.15238
Autor:
Jasmina Ahluwalia, Matthias Watzka, Johannes Oldenburg, Anita Tahlan, Chandrika Azad, Vidushi Mahajan
Publikováno v:
Journal of Pediatric Hematology/Oncology. 43:e580-e582
We present a family who suffered recurrent sibling losses due to vitamin K deficiency bleed. The index child was asymptomatic at presentation, had normal clinical examination, and was investigated for coagulation disorders in view of previous 3 sibli
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab2014f40340c34c61be0b586f1f0278
https://doi.org/10.1097/mph.0000000000001833
https://doi.org/10.1097/mph.0000000000001833
Autor:
Johannes Oldenburg, Veit Hornung, Arijit Biswas, Kerstin Liphardt, Matthias Watzka, Katrin J. Czogalla, Klara Höning
Publikováno v:
Blood Advances. 2:691-702
Vitamin K reduction is catalyzed by 2 enzymes in vitro: the vitamin K 2,3-epoxide reductase complex subunit 1 (VKORC1) and its isozyme VKORC1-like1 (VKORC1L1). In vivo, VKORC1 reduces vitamin K to sustain γ-carboxylation of vitamin K-dependent prote
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::061db01697df28353c6a79448605eadd
https://doi.org/10.1182/bloodadvances.2017006775
https://doi.org/10.1182/bloodadvances.2017006775
Autor:
Osman El-Maarri, Maja Walier, Frank Behne, Jan van Üüm, Heike Singer, Amalia Diaz-Lacava, Nicole Nüsgen, Barbara Niemann, Matthias Watzka, Jochen Reinsberg, Hans van der Ven, Thomas Wienker, Birgit Stoffel-Wagner, Rainer Schwaab, Johannes Oldenburg
Publikováno v:
PLoS ONE, Vol 6, Iss 1, p e16252 (2011)
Previously, we reported on inter-individual and gender specific variations of LINE-1 methylation in healthy individuals. In this study, we investigated whether this variability could be influenced by age or sex hormones in humans. To this end, we stu
Externí odkaz:
https://doaj.org/article/176df10339f94d409a07a8a43d9efde4
Autor:
Katrin J. Czogalla, Veit Hornung, Kerstin Liphardt, Arijit Biswas, Matthias Watzka, Klara Höning, Johannes Oldenburg
Publikováno v:
Nature Structural & Molecular Biology. 24:77-85
Vitamin K epoxide reductase (VKOR) catalyzes the reduction of vitamin K quinone and vitamin K 2,3-epoxide, a process essential to sustain γ-carboxylation of vitamin K-dependent proteins. VKOR is also a therapeutic target of warfarin, a treatment for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f7623221f4c051717708fafa9d0720f9
https://doi.org/10.1038/nsmb.3338
https://doi.org/10.1038/nsmb.3338