Výsledky vyhledávání - "Matthias Wallert"

Adaptive Flexible Sialylated Nanogels as Highly Potent Influenza A Virus Inhibitors

Autor: Rainer Haag, Malte Hilsch, Daniel Lauster, Jose Luis Cuellar-Camacho, Chuanxiong Nie, Sumati Bhatia, Stephan Block, Matthias Wallert, Badri Parshad, Andreas Herrmann, Christoph Böttcher, Kai Ludwig

Publikováno v: Angewandte Chemie (International Ed. in English)
Angewandte Chemie International Edition

Flexible multivalent 3D nanosystems that can deform and adapt onto the virus surface via specific ligand–receptor multivalent interactions can efficiently block virus adhesion onto the cell. We here report on the synthesis of a 250 nm sized flexibl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41b093d19952f6ed899787b46236cf33
https://doi.org/10.1002/ange.202006145

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Polysulfate hemmen durch elektrostatische Wechselwirkungen die SARS-CoV-2-Infektion

Autor: Anil Kumar Sahoo, Jakob Trimpert, Matthias Wallert, Rainer Haag, Gergo Peter Szekeres, Benedikt B. Kaufer, Kevin Pagel, Matthias Ballauff, Stephan Block, Paria Pouyan, Yannic Kerkhoff, Daniel Lauster, Roland R. Netz, Chuanxiong Nie, Jens Dernedde

Publikováno v: Angewandte Chemie

Wir zeigen, dass negativ geladene Polysulfate durch elektrostatische Wechselwirkungen an das Spike-Protein von SARS-CoV-2 binden. Durch einen Plaquereduktionstest verglichen wir die hemmende Wirkung von Heparin, Pentosanpolysulfat, linearem Polyglyce

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b322c2bafe4c91dcfa7d1720bc694fed
https://hdl.handle.net/21.11116/0000-0008-D651-B21.11116/0000-0008-D655-7

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Polysulfates Block SARS-CoV-2 Uptake via Electrostatic Interactions

Autor: Chuanxiong Nie, Paria Pouyan, Daniel Lauster, Jakob Trimpert, Yannic Kerkhoff, Gergo Peter Szekeres, Matthias Wallert, Stephan Block, Anil Kumar Sahoo, Jens Dernedde, Kevin Pagel, Benedikt B. Kaufer, Roland R. Netz, Matthias Ballauff, Rainer Haag

Here we report that negatively charged polysulfates can bind to the spike protein of SARS-CoV-2 via electrostatic interactions. Using a plaque reduction assay, we compare inhibition of SARS-CoV-2 by heparin, pentosan sulfate, linear polyglycerol sulf

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d85dde8d735c015b793cfea73a0ed452
https://doi.org/10.26434/chemrxiv.14074070

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Heteromultivalent topology-matched nanostructures as potent and broad-spectrum influenza A virus inhibitors

Autor: Chong Cheng, Sumati Bhatia, Stephan Block, Rainer Haag, Vahid Ahmadi, Yannic Kerkhoff, Marlena Stadtmüller, Thorsten Wolff, Chuanxiong Nie, Badri Parshad, Matthias Wallert

Publikováno v: Science Advances

A broad-spectrum heteromultivalent influenza inhibitor is developed by using the host cell membrane on an inverted virus scaffold.
Here, we report the topology-matched design of heteromultivalent nanostructures as potent and broad-spectrum virus

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::214ca9e20bea959c52146ec1ef0ba952
http://europepmc.org/articles/PMC7775783

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Automated Solvent-Free Polymerization of Hyperbranched Polyglycerol with Tailored Molecular Weight by Online Torque Detection

Autor: Mathias Dimde, Vahid Ahmadi, Rainer Haag, Stephan Block, Johann Plaschke, Matthias Wallert

Polymerization processes with high reproducibility, traceability, and nontoxic compounds are required for biomedical applications. Here an automated solvent-free polymerization of hyperbranched polyglycerol has been established on a multiple-hundred

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::66276ca034165c00b96d4cd91bfc4771

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Polysulfates block SARS-CoV-2 uptake through electrostatic interactions

Autor: Matthias Ballauff, Paria Pouyan, Chuanxiong Nie, Rainer Haag, Gergo Peter Szekeres, Benedikt B. Kaufer, Kevin Pagel, Daniel Lauster, Jens Dernedde, Matthias Wallert, Yannic Kerkhoff, Stephan Block, Jakob Trimpert, Anil Kumar Sahoo, Roland R. Netz

Publikováno v: Angewandte Chemie International Edition
Angewandte Chemie
ChemRxiv
Angewandte Chemie (International Ed. in English)

Here we report that negatively charged polysulfates can bind to the spike protein of SARS‐CoV‐2 via electrostatic interactions. Using a plaque reduction assay, we compare inhibition of SARS‐CoV‐2 by heparin, pentosan sulfate, linear polyglyce

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2fef26cd2d0a0c8ad217bcdbb2e86bc7
https://hdl.handle.net/21.11116/0000-0008-ED68-921.11116/0000-0008-ED69-821.11116/0000-0008-1CB4-E

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Mucin-Inspired, High Molecular Weight Virus Binding Inhibitors Show Biphasic Binding Behavior to Influenza A Viruses

Autor: Rainer Haag, Jayachandran N. Kizhakkedathu, Sumati Bhatia, Kai Ludwig, Parambath Anilkumar, Srinivas Abbina, Stephan Block, Chuanxiong Nie, Matthias Wallert

Multivalent binding inhibitors are a promising new class of antivirals that prevent virus infections by inhibiting virus binding to cell membranes. The design of these inhibitors is challenging as many properties, for example, inhibitor size and func

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f6f0578001f3985339b97cda735451b2
https://doi.org/10.1002/smll.202004635

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