Zobrazeno 1 - 10
of 368
pro vyhledávání: '"Matthias W Hentze"'
Autor:
Madhuri Bhuvanagiri, Joe Lewis, Kerstin Putzker, Jonas P Becker, Stefan Leicht, Jeroen Krijgsveld, Richa Batra, Brad Turnwald, Bogdan Jovanovic, Christian Hauer, Jana Sieber, Matthias W Hentze, Andreas E Kulozik
Publikováno v:
EMBO Molecular Medicine, Vol 6, Iss 12, Pp 1593-1609 (2014)
Abstract Nonsense‐mediated RNA decay (NMD) is an RNA‐based quality control mechanism that eliminates transcripts bearing premature translation termination codons (PTC). Approximately, one‐third of all inherited disorders and some forms of cance
Externí odkaz:
https://doaj.org/article/f60c809ba8904c2d9ca28ebfc530c5e8
Autor:
Claudia M Casanova, Peter Sehr, Kerstin Putzker, Matthias W Hentze, Beate Neumann, Kent E Duncan, Christian Thoma
Publikováno v:
PLoS ONE, Vol 7, Iss 9, p e45943 (2012)
Proteins that promote angiogenesis, such as vascular endothelial growth factor (VEGF), are major targets for cancer therapy. Accordingly, proteins that specifically activate expression of factors like VEGF are potential alternative therapeutic target
Externí odkaz:
https://doaj.org/article/ecb2d99af534436ca8ac95aebf3c57a7
Autor:
Traude H Beilharz, David T Humphreys, Jennifer L Clancy, Rolf Thermann, David I K Martin, Matthias W Hentze, Thomas Preiss
Publikováno v:
PLoS ONE, Vol 4, Iss 8, p e6783 (2009)
Animal microRNAs (miRNAs) typically regulate gene expression by binding to partially complementary target sites in the 3' untranslated region (UTR) of messenger RNA (mRNA) reducing its translation and stability. They also commonly induce shortening o
Externí odkaz:
https://doaj.org/article/83ced30232c94b3c947cf5af2fba3c4b
Publikováno v:
PLoS Biology, Vol 7, Iss 5, p e1000120 (2009)
Exon junction complexes (EJCs) link nuclear splicing to key features of mRNA function including mRNA stability, translation, and localization. We analyzed the formation of EJCs by the spliceosome, the physiological EJC assembly machinery. We studied
Externí odkaz:
https://doaj.org/article/36b711b1a142448faa617a8356587937
Publikováno v:
Open Biology, Vol 10, Iss 2 (2020)
RNA-binding proteins typically change the fate of RNA, such as stability, translation or processing. Conversely, we recently uncovered that the small non-coding vault RNA 1-1 (vtRNA1-1) directly binds to the autophagic receptor p62/SQSTM1 and changes
Externí odkaz:
https://doaj.org/article/6af18fc020704c26b9397f0db7f7d3ee
Autor:
Amy Cooke, Thomas Schwarzl, Ina Huppertz, Gertjan Kramer, Panagiotis Mantas, Anne-Marie Alleaume, Wolfgang Huber, Jeroen Krijgsveld, Matthias W. Hentze
Publikováno v:
Cell Reports, Vol 27, Iss 11, Pp 3097-3106.e5 (2019)
Summary: Sufficient amino acid supplies are critical for protein synthesis and, thus, cell growth and proliferation. Specialized transporters mediate amino acid exchange across membranes and their regulation is critical for amino acid homeostasis. He
Externí odkaz:
https://doaj.org/article/03477fa50d7c4af68babb8d83d2937bc
Autor:
Maud Dupont, Tim Krischuns, Quentin Giai-Gianetto, Sylvain Paisant, Stefano Bonazza, Jean-Baptiste Brault, Thibaut Douché, Joel I Perez-Perri, Matthias W Hentze, Stephen Cusack, Mariette Matondo, Catherine Isel, David G Courtney, Nadia Naffakh
Recent technical advances have significantly improved our understanding of the RNA-binding protein (RBP) repertoire present within eukaryotic cells, with a particular focus on the RBPs that interact with cellular polyadenylated mRNAs. However, recent
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27588ea7439c895daeb07877156ed5b9
https://hal-pasteur.archives-ouvertes.fr/pasteur-04093384
https://hal-pasteur.archives-ouvertes.fr/pasteur-04093384
Autor:
Joel I. Perez-Perri, Dunja Ferring-Appel, Ina Huppertz, Thomas Schwarzl, Sudeep Sahadevan, Frank Stein, Mandy Rettel, Bruno Galy, Matthias W. Hentze
Publikováno v:
Nature Communications. 14
System-wide approaches have unveiled an unexpected breadth of the RNA-bound proteomes of cultured cells. Corresponding information regarding RNA-binding proteins (RBPs) of mammalian organs is still missing, largely due to technical challenges. Here,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1019b3f25790f4fe59f21b0e89b28ef0
https://doi.org/10.1038/s41467-023-37494-w
https://doi.org/10.1038/s41467-023-37494-w
Autor:
Lena Muckenthaler, Oriana Marques, Silvia Colucci, Joachim Kunz, Piotr Fabrowski, Thomas Bast, Sandro Altamura, Britta Höchsmann, Hubert Schrezenmeier, Monika Langlotz, Paulina Richter-Pechanska, Tobias Rausch, Nicole Hofmeister-Mielke, Nikolas Gunkel, Matthias W. Hentze, Andreas E. Kulozik, Martina U. Muckenthaler
Publikováno v:
Blood. 139:1418-1422
Muckenthaler et al describe a novel form of hemochromatosis caused by a constitutional PIGA mutation in 3 children with associated neurologic dysfunction. Hemochromatosis results from decreased hepcidin, which is regulated by HFE, hemojuvelin (HJV),
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::698e4e7d6a640673fa87491accd843ca
https://doi.org/10.1182/blood.2021013519
https://doi.org/10.1182/blood.2021013519
Autor:
Christian Hauer, Jana Sieber, Thomas Schwarzl, Ina Hollerer, Tomaz Curk, Anne-Marie Alleaume, Matthias W. Hentze, Andreas E. Kulozik
Publikováno v:
Cell Reports, Vol 16, Iss 6, Pp 1588-1603 (2016)
The exon junction complex (EJC) connects spliced mRNAs to posttranscriptional processes including RNA localization, transport, and regulated degradation. Here, we provide a comprehensive analysis of bona fide EJC binding sites across the transcriptom
Externí odkaz:
https://doaj.org/article/55c4f6dafa4a4fb68e162596c8e9bec5