Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Matthias Tschöp"'
Autor:
Shada Abuhattum, Petra Kotzbeck, Raimund Schlüßler, Alexandra Harger, Angela Ariza de Schellenberger, Kyoohyun Kim, Joan-Carles Escolano, Torsten Müller, Jürgen Braun, Martin Wabitsch, Matthias Tschöp, Ingolf Sack, Marko Brankatschk, Jochen Guck, Kerstin Stemmer, Anna V. Taubenberger
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-17 (2022)
Abstract Adipose tissue expansion involves both differentiation of new precursors and size increase of mature adipocytes. While the two processes are well balanced in healthy tissues, obesity and diabetes type II are associated with abnormally enlarg
Externí odkaz:
https://doaj.org/article/d5ed2708d75f45e88b13545aa722713e
Autor:
Mar Quiñones, Omar Al-Massadi, Cintia Folgueira, Stephan Bremser, Rosalía Gallego, Leonardo Torres-Leal, Roberta Haddad-Tóvolli, Cristina García-Caceres, Rene Hernandez-Bautista, Brian Y. H. Lam, Daniel Beiroa, Estrella Sanchez-Rebordelo, Ana Senra, Jose A. Malagon, Patricia Valerio, Marcos F. Fondevila, Johan Fernø, Maria M. Malagon, Raian Contreras, Paul Pfluger, Jens C. Brüning, Giles Yeo, Matthias Tschöp, Carlos Diéguez, Miguel López, Marc Claret, Peter Kloppenburg, Guadalupe Sabio, Ruben Nogueiras
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-16 (2018)
Emerging studies suggest that p53 is an important regulator of energy metabolism, yet there is little known about the metabolic function of this tumor suppressor in the hypothalamus. Here, authors illustrate that p53, specifically in AgRP neurons, is
Externí odkaz:
https://doaj.org/article/e3abcb467c8540338b4c0581b476791c
Publikováno v:
Frontiers in Psychiatry, Vol 9 (2018)
Objective: Patients' expectations about the benefit of an intervention are important determinants of the placebo effect. Little is known about the extent to which expectations influence outcomes of treatments in the field of appetite regulation. This
Externí odkaz:
https://doaj.org/article/f6194eedc496443ba674db0a050c019a
Autor:
Jessica Mühlhaus, Juliane Dinter, Daniela Nürnberg, Maren Rehders, Maren Depke, Janine Golchert, Georg Homuth, Chun-Xia Yi, Silke Morin, Josef Köhrle, Klaudia Brix, Matthias Tschöp, Gunnar Kleinau, Heike Biebermann
Publikováno v:
International Journal of Molecular Sciences, Vol 15, Iss 11, Pp 20638-20655 (2014)
The thyroid hormone derivative 3-iodothyronamine (3-T1AM) exerts metabolic effects in vivo that contradict known effects of thyroid hormones. 3-T1AM acts as a trace amine-associated receptor 1 (TAAR1) agonist and activates Gs signaling in vitro. Inte
Externí odkaz:
https://doaj.org/article/01d32e6a0fb248879446d52ba27bc108
Autor:
Anne Müller, Lars Niederstadt, Wenke Jonas, Chun-Xia Yi, Franziska Meyer, Petra Wiedmer, Jana Fischer, Carsten Grötzinger, Annette Schürmann, Matthias Tschöp, Gunnar Kleinau, Annette Grüters, Heiko Krude, Heike Biebermann
Publikováno v:
Frontiers in Endocrinology, Vol 7 (2016)
Intact melanocortin signaling via the G protein-coupled receptors (GPCRs) melanocortin receptor 4 (MC4R) and melanocortin receptor 3 (MC3R) is crucial for body weight maintenance. So far, no connection between melanocortin signaling and hypothalamic
Externí odkaz:
https://doaj.org/article/96d82d05fe2d4aada5986c9637c38bf6
Autor:
Juliane Dinter, Jessica Mühlhaus, Carolin Leonie Wienchol, Chun-Xia Yi, Daniela Nürnberg, Silke Morin, Annette Grüters, Josef Köhrle, Torsten Schöneberg, Matthias Tschöp, Heiko Krude, Gunnar Kleinau, Heike Biebermann
Publikováno v:
PLoS ONE, Vol 10, Iss 2, p e0117774 (2015)
Application of 3-iodothyronamine (3-T1AM) results in decreased body temperature and body weight in rodents. The trace amine-associated receptor (TAAR) 1, a family A G protein-coupled receptor, is a target of 3-T1AM. However, 3-T1AM effects still pers
Externí odkaz:
https://doaj.org/article/b0c02509514947a08b8c1bd908f4a23f
Autor:
Anne Müller, Gunnar Kleinau, Carolin L Piechowski, Timo D Müller, Brian Finan, Juliane Pratzka, Annette Grüters, Heiko Krude, Matthias Tschöp, Heike Biebermann
Publikováno v:
PLoS ONE, Vol 8, Iss 1, p e53347 (2013)
The G-protein coupled receptor 83 (GPR83) is an orphan G-protein coupled receptor for which the natural ligand(s) and signaling pathway(s) remain to be identified. Previous studies suggest a role of GPR83 in the regulation of thermogenesis and the co
Externí odkaz:
https://doaj.org/article/df7ca2fcedc64695af946ea4c4590a8c
Autor:
Rudolf L Riepl, Rainald Fischer, Hubert Hautmann, Gunther Hartmann, Timo D Müller, Matthias Tschöp, Marcell Toepfer, Bärbel Otto
Publikováno v:
PLoS ONE, Vol 7, Iss 9, p e44445 (2012)
Acute mountain sickness (AMS) is characterized by headache often accompanied by gastrointestinal complaints that vary from anorexia through nausea to vomiting. The aim of this study was to investigate the influence of high altitude on plasma levels o
Externí odkaz:
https://doaj.org/article/d65e2e6b64544f94b1007ff22c2227c4
Publikováno v:
Diabetologia.
Glucagon-like peptide-1 (GLP-1) receptor agonists are established pharmaceutical therapies for the treatment of type 2 diabetes and obesity. They mimic the action of GLP-1 to reduce glucose levels through stimulation of insulin secretion and inhibiti
Publikováno v:
Nature Reviews Bioengineering. 1:154-155