Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Matthias Spiess"'
Autor:
Tânia D. F. Costa, Ting Zhuang, Julie Lorent, Emilia Turco, Helene Olofsson, Miriam Masia-Balague, Miao Zhao, Parisa Rabieifar, Neil Robertson, Raoul Kuiper, Jonas Sjölund, Matthias Spiess, Pablo Hernández-Varas, Uta Rabenhorst, Pernilla Roswall, Ran Ma, Xiaowei Gong, Johan Hartman, Kristian Pietras, Peter D. Adams, Paola Defilippi, Staffan Strömblad
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-18 (2019)
Oncogene induced senescence protects cells from unrestricted growth and cancer. Here, the authors show that PAK4 overrides this senescence in breast cancer cells through phosphorylation of RELB, thereby inhibiting transcription of the senescence regu
Externí odkaz:
https://doaj.org/article/b1b8d976c5c54a27ab395cced065f0c0
Autor:
Erik Verschueren, Matthias Spiess, Areti Gkourtsa, Teja Avula, Christiane Landgraf, Victor Tapia Mancilla, Aline Huber, Rudolf Volkmer, Barbara Winsor, Luis Serrano, Frans Hochstenbach, Ben Distel
Publikováno v:
PLoS ONE, Vol 10, Iss 6, p e0129229 (2015)
To explore the conservation of Src homology 3 (SH3) domain-mediated networks in evolution, we compared the specificity landscape of these domains among four yeast species, Saccharomyces cerevisiae, Ashbya gossypii, Candida albicans, and Schizosacchar
Externí odkaz:
https://doaj.org/article/de328133ff05496bb531a3a35611b990
Autor:
Matthias Spiess, Johan-Owen de Craene, Alphée Michelot, Bruno Rinaldi, Aline Huber, David G Drubin, Barbara Winsor, Sylvie Friant
Publikováno v:
PLoS ONE, Vol 8, Iss 4, p e61147 (2013)
The spatial and temporal regulation of actin polymerization is crucial for various cellular processes. Members of the Wiskott-Aldrich syndrome protein (WASP) family activate the Arp2/3-complex leading to actin polymerization. The yeast Saccharomyces
Externí odkaz:
https://doaj.org/article/24692432508646c1957cd64b584cebf6
Autor:
Matthias Spiess, Miao Zhao, Staffan Strömblad, Henrik J. Johansson, Jianjiang Hu, Helene Olofsson, Janne Lehtiö
Publikováno v:
Oncotarget
p21-activated kinase 4 (PAK4) regulates cell proliferation, apoptosis, cell motility and F-actin remodeling, but the PAK4 interactome has not been systematically analyzed. Here, we comprehensively characterized the human PAK4 interactome by iTRAQ qua
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec01020e8eb35c450ce266686b89bedf
http://europepmc.org/articles/PMC5652764
http://europepmc.org/articles/PMC5652764
Autor:
Kristian Pietras, Uta Rabenhorst, Jonas Sjölund, Miao Zhao, Pernilla Roswall, Ran Ma, Parisa Rabieifar, Xiaowei Gong, Peter D. Adams, Staffan Strömblad, Raoul Kuiper, Tânia D. F. Costa, Neil Robertson, Matthias Spiess, Emilia Turco, Paola Defilippi, Johan Hartman, Ting Zhuang, Julie Lorent, Miriam Masia-Balague, Pablo Hernández-Varas, Helene Olofsson
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-18 (2019)
Nature Communications
Nature Communications
Overcoming cellular growth restriction, including the evasion of cellular senescence, is a hallmark of cancer. We report that PAK4 is overexpressed in all human breast cancer subtypes and associated with poor patient outcome. In mice, MMTV-PAK4 overe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a984cae248de902e5ff0d1fff703ff67
http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-398817
http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-398817
Autor:
Anna Oddone, Matthias Spiess, Staffan Strömblad, Helene Olofsson, John G. Lock, Pablo Hernández-Varas, Hans Blom, Dominic Waithe, Melike Lakadamyali
Publikováno v:
The Journal of Cell Biology
Through two superresolution microscopy techniques, STED and STORM, Spiess et al. visualize the organization of integrins in focal adhesions and show that active and inactive β1 integrins assemble into distinct nanoclusters within adhesions, suggesti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9a39a64003d6fa13b1ab77960cf4acb
http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-232634
http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-232634
Publikováno v:
Molecular Biology of the Cell
CCTε, a subunit of the oligomeric CCT molecular chaperone, interacts with the cotranscription factor MRTF-A, thus influencing MRTF-A nuclear accumulation upon serum stimulation. This establishes a novel function for CCTε when monomeric and reveals
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5daa552ec669e1f4ca0d156073a15701
https://doi.org/10.1091/mbc.e15-01-0048
https://doi.org/10.1091/mbc.e15-01-0048
Autor:
Anna E. Masser, Marc R. Friedländer, Matthias Spiess, Sebastian D. Mackowiak, Matteo Biancospino, Roger Karlsson, Michaela Nejedla, Zhilun Li
Publikováno v:
Journal of molecular biology. 429(7)
Profilin is vital for actin organisation in eukaryotic cells. It controls actin filament formation by binding monomeric actin and numerous proteins involved in polarised actin assembly. Important for the latter is the interaction surface formed by th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c065f404b7c1ce8a41dfaec1d0ba7153
https://pubmed.ncbi.nlm.nih.gov/28077285
https://pubmed.ncbi.nlm.nih.gov/28077285
Publikováno v:
Journal of molecular biology. 427(17)
Chaperonin containing tailless complex polypeptide 1 (CCT) forms a classical chaperonin barrel structure where two rings of subunits surround a central cavity. Each ring consists of eight distinct subunits, creating a complex binding interface that m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5dfe8c73bb497580caffe272c885024d
https://pubmed.ncbi.nlm.nih.gov/26101841
https://pubmed.ncbi.nlm.nih.gov/26101841
Autor:
Rudolf Volkmer, Barbara Winsor, Teja Avula, Luis Serrano, Matthias Spiess, Christiane Landgraf, Frans Hochstenbach, Victor Tapia Mancilla, Areti Gkourtsa, Ben Distel, Aline Huber, Erik Verschueren
Publikováno v:
PLoS ONE, 10(6). Public Library of Science
PLoS ONE
PLoS ONE, Vol 10, Iss 6, p e0129229 (2015)
PLoS ONE
PLoS ONE, Vol 10, Iss 6, p e0129229 (2015)
To explore the conservation of Src homology 3 (SH3) domain-mediated networks in evolution, we compared the specificity landscape of these domains among four yeast species, Saccharomyces cerevisiae, Ashbya gossypii, Candida albicans, and Schizosacchar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07bbd7a564a5f554eff1073f8f8b007e
https://doi.org/10.1371/journal.pone.0129229
https://doi.org/10.1371/journal.pone.0129229