Zobrazeno 1 - 10
of 972
pro vyhledávání: '"Matthias Schwab"'
Autor:
Christina Kovar, Helena Leonie Hanae Loer, Simeon Rüdesheim, Laura Maria Fuhr, Fatima Zahra Marok, Dominik Selzer, Matthias Schwab, Thorsten Lehr
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology, Vol 13, Iss 7, Pp 1144-1159 (2024)
Abstract Dasatinib, a second‐generation tyrosine kinase inhibitor, is approved for treating chronic myeloid and acute lymphoblastic leukemia. As a sensitive cytochrome P450 (CYP) 3A4 substrate and weak base with strong pH‐sensitive solubility, da
Externí odkaz:
https://doaj.org/article/1be7c6a61b9549f492988303267df6f2
Autor:
Helena Leonie Hanae Loer, Christina Kovar, Simeon Rüdesheim, Fatima Zahra Marok, Laura Maria Fuhr, Dominik Selzer, Matthias Schwab, Thorsten Lehr
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology, Vol 13, Iss 6, Pp 926-940 (2024)
Abstract The first‐generation tyrosine kinase inhibitor imatinib has revolutionized the development of targeted cancer therapy and remains among the frontline treatments, for example, against chronic myeloid leukemia. As a substrate of cytochrome P
Externí odkaz:
https://doaj.org/article/a46afdd0540e4e8eb56c221dcc371740
Autor:
Zhendong Chen, Max Taubert, Chunli Chen, Jana Boland, Qian Dong, Muhammad Bilal, Charalambos Dokos, Bertil Wachall, Manfred Wargenau, Bernhard Scheidel, Martin H. J. Wiesen, Elke Schaeffeler, Roman Tremmel, Matthias Schwab, Uwe Fuhr
Publikováno v:
Drugs in R&D, Vol 24, Iss 2, Pp 187-199 (2024)
Abstract Introduction Noscapine is a commonly used cough suppressant, with ongoing research on its anti-inflammatory and anti-tumor properties. The drug has a pronounced pharmacokinetic variability. Objective This evaluation aims to describe the phar
Externí odkaz:
https://doaj.org/article/42daba1e18d440cc84cc7f24d1f6008e
Autor:
Matthias Schwab, Andrew Chan, Anna-Katharina Eser, Boris Kallmann, Dieter Pöhlau, Joachim Richter, Torsten B. Wagner, Christoph Grothe
Publikováno v:
Neurology and Therapy, Vol 13, Iss 3, Pp 641-653 (2024)
Abstract Introduction Treatment adherence is a critical success factor in the disease-modifying therapy (DMT) of multiple sclerosis (MS). The REBISTART study prospectively evaluated adherence in patients using components of a patient support program
Externí odkaz:
https://doaj.org/article/37e20567ddba4394b0fa4dbb255d5e11
Autor:
Ali El‐Ayoubi, Arsen Arakelyan, Moritz Klawitter, Luisa Merk, Siras Hakobyan, Irene Gonzalez‐Menendez, Leticia Quintanilla Fend, Per Sonne Holm, Wolfgang Mikulits, Matthias Schwab, Lusine Danielyan, Ulrike Naumann
Publikováno v:
Molecular Oncology, Vol 18, Iss 3, Pp 528-546 (2024)
Neural stem cells (NSCs) are considered to be valuable candidates for delivering a variety of anti‐cancer agents, including oncolytic viruses, to brain tumors. However, owing to the previously reported tumorigenic potential of NSC cell lines after
Externí odkaz:
https://doaj.org/article/dcaccfb7170a43d7ba680bd39fee16e9
Autor:
Karolin Weigel, Carsten M. Klingner, Stefan Brodoehl, Franziska Wagner, Matthias Schwab, Daniel Güllmar, Thomas E. Mayer, Felix V. Güttler, Ulf Teichgräber, Christian Gaser
Publikováno v:
Frontiers in Neuroscience, Vol 18 (2024)
The interrelation between acute ischemic stroke, persistent disability, and uncertain prognosis underscores the need for improved methods to predict clinical outcomes. Traditional approaches have largely focused on analysis of clinical metrics, lesio
Externí odkaz:
https://doaj.org/article/bc35e662fb8648bbaf53b8eed43aece6
Autor:
Marvin Ritter, Olaposi Yomade, Ben-Ole Holtz, Stefanie Deinhardt-Emmer, Aaron Lawson McLean, Stefanie Hartinger, Julia Bechwar, Matthias Schwab, André Huss, Christian Mawrin, Hubertus Axer, Karin G. Schrenk, Philipp A. Reuken, Irina Mäurer
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
BackgroundThe hepatitis E virus (HEV) can cause acute viral hepatitis with or without neurological manifestations, and occasionally progresses to chronic infection in immunocompromised individuals. The management of chronic HEV infection in cancer pa
Externí odkaz:
https://doaj.org/article/677c0bb5042e4785b2ce211cf129b68a
Autor:
Michael Hecker, Brit Fitzner, Dirk Koczan, Juliane Klehmet, Matthias Grothe, Matthias Schwab, Alexander Winkelmann, Stefanie Meister, Ales Dudesek, Isis Ludwig-Portugall, Klaus Eulitz, Uwe Klaus Zettl
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 175, Iss , Pp 116721- (2024)
Background: Despite remarkable advances in the therapy of multiple sclerosis (MS), patients with MS may still experience relapses. High-dose short-term methylprednisolone (MP) remains the standard treatment in the acute management of MS relapses due
Externí odkaz:
https://doaj.org/article/80176124a1a847b3a174445f2c7f5543
Autor:
Helmut Bischof, Selina Maier, Piotr Koprowski, Bogusz Kulawiak, Sandra Burgstaller, Joanna Jasińska, Kristian Serafimov, Monika Zochowska, Dominic Gross, Werner Schroth, Lucas Matt, David Arturo Juarez Lopez, Ying Zhang, Irina Bonzheim, Florian A Büttner, Falko Fend, Matthias Schwab, Andreas L Birkenfeld, Roland Malli, Michael Lämmerhofer, Piotr Bednarczyk, Adam Szewczyk, Robert Lukowski
Publikováno v:
eLife, Vol 12 (2024)
Alterations in the function of K+ channels such as the voltage- and Ca2+-activated K+ channel of large conductance (BKCa) reportedly promote breast cancer (BC) development and progression. Underlying molecular mechanisms remain, however, elusive. Her
Externí odkaz:
https://doaj.org/article/60f91b8d7664470fa1f56e117e4caef3
Autor:
Gayane Hrachia Buniatian, Ute Schwinghammer, Roman Tremmel, Holger Cynis, Thomas S. Weiss, Ralf Weiskirchen, Volker M. Lauschke, Sonia Youhanna, Isbaal Ramos, Maria Valcarcel, Torgom Seferyan, Jens‐Ulrich Rahfeld, Vera Rieckmann, Kathrin Klein, Marine Buadze, Victoria Weber, Valentina Kolak, Rolf Gebhardt, Scott L. Friedman, Ulrike C. Müller, Matthias Schwab, Lusine Danielyan
Publikováno v:
Advanced Science, Vol 11, Iss 18, Pp n/a-n/a (2024)
Abstract The hepatic content of amyloid beta (Aβ) decreases drastically in human and rodent cirrhosis highlighting the importance of understanding the consequences of Aβ deficiency in the liver. This is especially relevant in view of recent advance
Externí odkaz:
https://doaj.org/article/a502efb1c1864047b669d0f146231d64