Zobrazeno 1 - 10
of 34
pro vyhledávání: '"Matthias Schranzhofer"'
Autor:
Gulzhakhan Sadvakassova, Kerstin Tiedemann, Kieran J. D. Steer, Nicholas Mikolajewicz, Mariya Stavnichuk, Irene In‐Kyung Lee, Zarina Sabirova, Matthias Schranzhofer, Svetlana V. Komarova
Publikováno v:
Physiological Reports, Vol 9, Iss 3, Pp n/a-n/a (2021)
Abstract Hematopoietic disorders, particularly hemolytic anemias, commonly lead to bone loss. We have previously reported that actively proliferating cancer cells stimulate osteoclastogenesis from late precursors in a RANKL‐independent manner. We t
Externí odkaz:
https://doaj.org/article/483313399c9541078e21379f654efabc
Publikováno v:
Haematologica, Vol 102, Iss 8 (2017)
Vertebrate heme synthesis requires three substrates: succinyl-CoA, which regenerates in the tricarboxylic acid cycle, iron and glycine. For each heme molecule synthesized, one atom of iron and eight molecules of glycine are needed. Inadequate deliver
Externí odkaz:
https://doaj.org/article/90d8420d81f04d06b022f462eedfc167
Autor:
Kerstin Tiedemann, Nicholas Mikolajewicz, Zarina Sabirova, Svetlana V. Komarova, Matthias Schranzhofer, Irene In‐Kyung Lee, Kieran J. D. Steer, Mariya Stavnichuk, Gulzhakhan Sadvakassova
Publikováno v:
Physiological Reports, Vol 9, Iss 3, Pp n/a-n/a (2021)
Physiological Reports
Physiological Reports
Hematopoietic disorders, particularly hemolytic anemias, commonly lead to bone loss. We have previously reported that actively proliferating cancer cells stimulate osteoclastogenesis from late precursors in a RANKL‐independent manner. We theorized
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4882a893a83ad08519b4c423b171ef53
https://doaj.org/article/483313399c9541078e21379f654efabc
https://doaj.org/article/483313399c9541078e21379f654efabc
Autor:
Prem Ponka, Lucie Carrière, Matthias Schranzhofer, Anna Derjuga, Barry H. Paw, Volker Blank, Jadwiga J. Gasiorek, Louay Mardini
Publikováno v:
Biochemical Journal. 432:145-151
Late-stage erythroid cells synthesize large quantities of haemoglobin, a process requiring the co-ordinated regulation of globin and haem synthesis as well as iron uptake. In the present study, we investigated the role of the ERK (extracellular-signa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d102a295bc71fdfbce4b14d508325c97
https://doi.org/10.1042/bj20100541
https://doi.org/10.1042/bj20100541
Autor:
Matthias Schranzhofer, Shan Soe-Lin, Prem Ponka, Sameer S. Apte, Billy Andriopoulos, Daniel Garcia-Santos, Tanya Kahawita, Marc C. Andrews
Publikováno v:
Proceedings of the National Academy of Sciences. 106:5960-5965
Natural resistance-associated macrophage protein 1 (Nramp1) is a divalent metal transporter expressed exclusively in phagocytic cells. We hypothesized that macrophage Nramp1 may participate in the recycling of iron acquired from phagocytosed senescen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f4a8bbf8880e9c2218f8b76c05ef8c83
https://doi.org/10.1073/pnas.0900808106
https://doi.org/10.1073/pnas.0900808106
Autor:
Matthias Schranzhofer, Javier Antonio Cabrera, Stephan Kopp, Peter Chiba, Hartmut Beug, Manfred Schifrer, Ernst W. Müllner
Publikováno v:
Blood. 107:4159-4167
Terminal erythropoiesis is accompanied by extreme demand for iron to ensure proper hemoglobinization. Thus, erythroblasts must modify the “standard” post-transcriptional feedback regulation, balancing expression of ferritin (Fer; iron storage) ve
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eab01efb14b905960fc5e612929e2d3e
https://doi.org/10.1182/blood-2005-05-1809
https://doi.org/10.1182/blood-2005-05-1809
Autor:
Brigitte Sturm, Joseph P. Sarsero, Ursula Rauen, Barbara Scheiber-Mojdehkar, Ute Bistrich, Herbert de Groot, Panos A. Ioannou, Matthias Schranzhofer, Frank Petrat
Publikováno v:
Journal of Biological Chemistry. 280:6701-6708
Friedreich's ataxia (FRDA) is caused by low expression of frataxin, a small mitochondrial protein. Studies with both yeast and mammals have suggested that decreased frataxin levels lead to elevated intramitochondrial concentrations of labile (chelata
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7d4a808c58df70819ac50b2ee1113a6c
https://doi.org/10.1074/jbc.m408717200
https://doi.org/10.1074/jbc.m408717200
Autor:
José Artur Bogo Chies, Mehrad Mojtahed Jaberi, Monika Horvathova, Prem Ponka, Matthias Schranzhofer, Daniel Garcia-Santos, Alex D. Sheftel
Publikováno v:
Blood. 123(14)
Heme is essential for the function of all aerobic cells. However, it can be toxic when it occurs in a non-protein-bound form; cells maintain a fine balance between heme synthesis and catabolism. The only physiological mechanism of heme degradation is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b2baaac4ce245cd0742a3db6ed5ec314
https://pubmed.ncbi.nlm.nih.gov/24700716
https://pubmed.ncbi.nlm.nih.gov/24700716
Autor:
Anton Bauer, Lioba Lobmayr, Hartmut Beug, Ernst W. Müllner, Matthias Schranzhofer, Anthony A. Infante, Wolfgang Mikulits, Helmut Dolznig
Publikováno v:
Blood. 94:4321-4332
In immortalized cells of the erythroid lineage, the iron-regulatory protein (IRP) has been suggested to coregulate biosynthesis of the iron storage protein ferritin and the erythroid delta-aminolevulinate synthase (eALAS), a key enzyme in heme produc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8922c2982ec265a2bc77d8e41a7afbdc
https://doi.org/10.1182/blood.v94.12.4321
https://doi.org/10.1182/blood.v94.12.4321
Publikováno v:
Mutation Research/Reviews in Mutation Research. 437:219-230
Tight regulation of iron metabolism is crucial to avoid formation of deleterious radicals and is mainly executed at the post-transcriptional level. The regulatory loops are exerted by trans-acting iron regulatory proteins (IRPs) and cis-acting stem-l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e299bb266b15d6153a61bfbcfd343849
https://doi.org/10.1016/s1383-5742(99)00085-x
https://doi.org/10.1016/s1383-5742(99)00085-x