Zobrazeno 1 - 10
of 40
pro vyhledávání: '"Matthias Schiedel"'
Autor:
Max Huber, Silas Wurnig, Lara Toy, Corinna Weiler, Nicole Merten, Evi Kostenis, Finn Hansen, Matthias Schiedel
Fluorescently labeled ligands are versatile molecular tools to study G protein-coupled receptors (GPCRs) and can be used for a range of different applications, including bioluminescence resonance energy transfer (BRET) assays and fluorescence microsc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28ce76e0737dc432caee3a2b8de5e8b2
https://doi.org/10.26434/chemrxiv-2023-d9d87-v2
https://doi.org/10.26434/chemrxiv-2023-d9d87-v2
A conserved intracellular allosteric binding site (IABS) has recently been identified at several G protein‐coupled receptors (GPCRs). Ligands targeting the IABS, so‐called intracellular allosteric antagonists, are highly promising compounds for p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a5f3b0391b40af2734e4a0821e15516d
https://opus4.kobv.de/opus4-fau/files/22752/CHEM_CHEM202202565.pdf
https://opus4.kobv.de/opus4-fau/files/22752/CHEM_CHEM202202565.pdf
Publikováno v:
Chemistry – A European Journal. 29
Publikováno v:
ACS Pharmacol Transl Sci
[Image: see text] The tubulin deacetylases Sirt2 and HDAC6 have been associated with the development of various diseases. Herein, we discuss recent approaches that enable cellular target engagement studies for these deacetylases and thus play a criti
Fluorescently labeled ligands are versatile molecular tools to study G protein-coupled receptors (GPCRs) and can be used for a range of different applications, including bioluminescence resonance energy transfer (BRET) assays. Here, we report the str
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d843fabacc11003ba8a5bd650a11b872
https://doi.org/10.26434/chemrxiv-2022-wg6cg-v2
https://doi.org/10.26434/chemrxiv-2022-wg6cg-v2
Autor:
Nathalie Wössner, Wolfgang Sippl, Sören Hammelmann, Oliver Einsle, Manfred Jung, Judit Ovádi, Attila Lehotzky, Dina Robaa, Matthias Schiedel, Judit Oláh, Sándor Szunyogh
Publikováno v:
Chembiochem
We have discovered the sirtuin‐rearranging ligands (SirReals) as a novel class of highly potent and selective inhibitors of the NAD+‐dependent lysine deacetylase sirtuin 2 (Sirt2). In previous studies, conjugation of a SirReal with a ligand for t
Autor:
Max E. Huber, Lara Toy, Maximilian F. Schmidt, Hannah Vogt, Julian Budzinski, Martin F. J. Wiefhoff, Nicole Merten, Evi Kostenis, Dorothee Weikert, Matthias Schiedel
Publikováno v:
Angewandte Chemie International Edition. 61
A conserved intracellular allosteric binding site (IABS) has recently been identified at several G protein-coupled receptors (GPCRs). Starting from vercirnon, an intracellular C-C chemokine receptor type 9 (CCR9) antagonist and previous phase III cli
Autor:
Max E. Huber, Lara Toy, Maximilian F. Schmidt, Hannah Vogt, Julian Budzinski, Martin F. J. Wiefhoff, Nicole Merten, Evi Kostenis, Dorothee Weikert, Matthias Schiedel
Publikováno v:
Angewandte Chemie. 134
Autor:
Matthias Schiedel
Publikováno v:
Angewandte Chemie (International ed. in English). 61(12)
"The greatest scientific advance of the next decade will be the implementation of artificial intelligence in any kind of academic discipline … When I was a kid I wanted to be a rock star …" Find out more about Matthias Schiedel in his Introducing
Autor:
David M. H. Ascough, Angelina R. Sekirnik, Mustafa Moroglu, Matthias Schiedel, Jos J. A. G. Kamps, Stuart J. Conway, Anna E. R. Chamberlain
Publikováno v:
Angewandte Chemie. 131:18096-18120