Zobrazeno 1 - 10
of 75
pro vyhledávání: '"Matthias Scheunemann"'
Autor:
Barbara Wenzel, Stefan R. Fritzsche, Magali Toussaint, Detlef Briel, Klaus Kopka, Peter Brust, Matthias Scheunemann, Winnie Deuther-Conrad
Publikováno v:
Pharmaceuticals, Vol 15, Iss 10, p 1272 (2022)
The cyclic nucleotide phosphodiesterase 2A is an intracellular enzyme which hydrolyzes the secondary messengers cAMP and cGMP and therefore plays an important role in signaling cascades. A high expression in distinct brain areas as well as in cancer
Externí odkaz:
https://doaj.org/article/b7b1f6b818274cb1ba344ecd96fb5720
Autor:
Oliver Clauß, Linda Schäker-Hübner, Barbara Wenzel, Magali Toussaint, Winnie Deuther-Conrad, Daniel Gündel, Rodrigo Teodoro, Sladjana Dukić-Stefanović, Friedrich-Alexander Ludwig, Klaus Kopka, Peter Brust, Finn K. Hansen, Matthias Scheunemann
Publikováno v:
Pharmaceuticals, Vol 15, Iss 3, p 324 (2022)
The degree of acetylation of lysine residues on histones influences the accessibility of DNA and, furthermore, the gene expression. Histone deacetylases (HDACs) are overexpressed in various tumour diseases, resulting in the interest in HDAC inhibitor
Externí odkaz:
https://doaj.org/article/830003203e3b458b81afb939ef4979aa
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 8, p 3832 (2021)
Cyclic nucleotide phosphodiesterases (PDEs) represent one of the key targets in the research field of intracellular signaling related to the second messenger molecules cyclic adenosine monophosphate (cAMP) and/or cyclic guanosine monophosphate (cGMP)
Externí odkaz:
https://doaj.org/article/de71802012cb4fd580460e904aa4ec24
Autor:
Rodrigo Teodoro, Matthias Scheunemann, Winnie Deuther-Conrad, Barbara Wenzel, Francesca Maria Fasoli, Cecilia Gotti, Mathias Kranz, Cornelius K. Donat, Marianne Patt, Ansel Hillmer, Ming-Qiang Zheng, Dan Peters, Jörg Steinbach, Osama Sabri, Yiyun Huang, Peter Brust
Publikováno v:
Molecules, Vol 20, Iss 10, Pp 18387-18421 (2015)
Changes in the expression of α7 nicotinic acetylcholine receptors (α7 nAChRs) in the human brain are widely assumed to be associated with neurological and neurooncological processes. Investigation of these receptors in vivo depends on the availabil
Externí odkaz:
https://doaj.org/article/f95193d25fe04787b30478887fbd5172
Autor:
Susann Schröder, Barbara Wenzel, Winnie Deuther-Conrad, Rodrigo Teodoro, Ute Egerland, Mathias Kranz, Matthias Scheunemann, Norbert Höfgen, Jörg Steinbach, Peter Brust
Publikováno v:
Molecules, Vol 20, Iss 6, Pp 9591-9615 (2015)
Phosphodiesterase 2A (PDE2A) is highly and specifically expressed in particular brain regions that are affected by neurological disorders and in certain tumors. Development of a specific PDE2A radioligand would enable molecular imaging of the PDE2A p
Externí odkaz:
https://doaj.org/article/287eedc5a653485480ce4d43236e0cb4
Autor:
Rien Ritawidya, Barbara Wenzel, Rodrigo Teodoro, Magali Toussaint, Mathias Kranz, Winnie Deuther-Conrad, Sladjana Dukic-Stefanovic, Friedrich-Alexander Ludwig, Matthias Scheunemann, Peter Brust
Publikováno v:
Molecules, Vol 24, Iss 22, p 4149 (2019)
A specific radioligand for the imaging of cyclic nucleotide phosphodiesterase 2A (PDE2A) via positron emission tomography (PET) would be helpful for research on the physiology and disease-related changes in the expression of this enzyme in the brain.
Externí odkaz:
https://doaj.org/article/6a3bf5d75cac4202901698f3cc2da175
Publikováno v:
Molecules, Vol 24, Iss 15, p 2791 (2019)
Phosphodiesterase 2A (PDE2A) is highly expressed in distinct areas of the brain, which are known to be related to neuropsychiatric diseases. The development of suitable PDE2A tracers for Positron Emission Tomography (PET) would permit the in vivo ima
Externí odkaz:
https://doaj.org/article/5c2b751622504c6896e0cc17240f31a3
Autor:
Detlef Briel, Peter Brust, Achim Hiller, Gregor Schwan, Aurélie Maisonial, Matthias Scheunemann, Steffen Fischer, Winnie Deuther-Conrad, Uta Funke
Publikováno v:
Pharmaceuticals, Vol 5, Iss 2, Pp 169-188 (2012)
Phosphodiesterase 10A (PDE10A) is a key enzyme of intracellular signal transduction which is involved in the regulation of neurotransmission. The molecular imaging of PDE10A by PET is expected to allow a better understanding of physiological and path
Externí odkaz:
https://doaj.org/article/7a428058c19f456db8b84413d8811248
Autor:
Susann Schröder, Barbara Wenzel, Winnie Deuther-Conrad, Rodrigo Teodoro, Mathias Kranz, Matthias Scheunemann, Ute Egerland, Norbert Höfgen, Detlef Briel, Jörg Steinbach, Peter Brust
Publikováno v:
Molecules, Vol 23, Iss 3, p 556 (2018)
Specific radioligands for in vivo visualization and quantification of cyclic nucleotide phosphodiesterase 2A (PDE2A) by positron emission tomography (PET) are increasingly gaining interest in brain research. Herein we describe the synthesis, the 18F-
Externí odkaz:
https://doaj.org/article/df2b6a0b9d3d4755a29a5f00617e3629
Publikováno v:
Molecules, Vol 21, Iss 5, p 650 (2016)
Cyclic nucleotide phosphodiesterases (PDEs) are a class of intracellular enzymes that inactivate the secondary messenger molecules, cyclic adenosine monophosphate (cAMP) and cyclic guanosine monophosphate (cGMP). Thus, PDEs regulate the signaling cas
Externí odkaz:
https://doaj.org/article/080b80bcecf243f8bfa85a8ad9faca6a