Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Matthias Samwer"'
Autor:
Felix Spira, Sara Cuylen-Haering, Shalin Mehta, Matthias Samwer, Anne Reversat, Amitabh Verma, Rudolf Oldenbourg, Michael Sixt, Daniel W Gerlich
Publikováno v:
eLife, Vol 6 (2017)
The actomyosin ring generates force to ingress the cytokinetic cleavage furrow in animal cells, yet its filament organization and the mechanism of contractility is not well understood. We quantified actin filament order in human cells using fluoresce
Externí odkaz:
https://doaj.org/article/081a6548fbaf44c69d7403d415d711cd
Autor:
Koray Kırlı, Samir Karaca, Heinz Jürgen Dehne, Matthias Samwer, Kuan Ting Pan, Christof Lenz, Henning Urlaub, Dirk Görlich
Publikováno v:
eLife, Vol 4 (2015)
CRM1 is a highly conserved, RanGTPase-driven exportin that carries proteins and RNPs from the nucleus to the cytoplasm. We now explored the cargo-spectrum of CRM1 in depth and identified surprisingly large numbers, namely >700 export substrates from
Externí odkaz:
https://doaj.org/article/b8195ee4d4fd49609bee2888b312029a
Autor:
Alberto Hernandez-Armendariz, Maximilian W. G. Schneider, Sara Cuylen-Haering, Daniel W. Gerlich, Mina Petrovic, Matthias Samwer, Liam J. Holt, Claudia Blaukopf
Publikováno v:
Nature
Gene expression in eukaryotes requires the effective separation of nuclear transcription and RNA processing from cytosolic translation1. This separation is achieved by the nuclear envelope, which controls the exchange of macromolecules through nuclea
Autor:
Ravichandran Mc, Mark Petronczki, Matthias Samwer, Jark Böttcher, Klaus Rumpel, Opher Gileadi, Leonhard Geist, J.A. Newman, Engen, Katja Hauer, Patrick Werni, Angeline E Gavard, Simone Lieb
Werner syndrome helicase (WRN) plays important roles in multiple pathways of DNA repair and the maintenance of genome integrity. Germline mutations in WRN give rise to Werner syndrome, a rare autosomal recessive progeroid syndrome that also features
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::76606eaeba86ec1aeabbf3224a87a361
Autor:
Matthias Samwer, Dirk Görlich, Philippe P. Roux, Mark Petronczki, Upamali Perera, Guillaume Charras, Geneviève Lavoie, Ewa K. Paluch, Murielle P. Serres, Binh An Truong Quang
Publikováno v:
Developmental Cell
Summary Most metazoan cells entering mitosis undergo characteristic rounding, which is important for accurate spindle positioning and chromosome separation. Rounding is driven by contractile tension generated by myosin motors in the sub-membranous ac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f0408d54420f87d745543757bb215e3
https://hdl.handle.net/21.11116/0000-0005-939F-221.11116/0000-0005-93A0-F21.11116/0000-0005-7B59-E
https://hdl.handle.net/21.11116/0000-0005-939F-221.11116/0000-0005-93A0-F21.11116/0000-0005-7B59-E
Autor:
J.A. Newman, Katja Hauer, Klaus Rumpel, Opher Gileadi, Patrick Werni, Madhwesh C Ravichandran, Angeline E Gavard, John R. Engen, Jark Böttcher, Simone Lieb, Leonhard Geist, Mark Petronczki, Matthias Samwer
Publikováno v:
Life Science Alliance
WRN is a key drug target for cancers with microsatellite instability. A crystal structure of the helicase domain of WRN identifies its unique features and provides a basis for structure-guided design of inhibitors.
Loss of WRN, a DNA repair heli
Loss of WRN, a DNA repair heli
Autor:
Felix Spira, Sara Cuylen-Haering, Shalin Mehta, Matthias Samwer, Anne Reversat, Amitabh Verma, Rudolf Oldenbourg, Michael Sixt, Daniel W Gerlich
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1954d662a1f3bb65c89ba935881eaf4e
https://doi.org/10.7554/elife.30867.020
https://doi.org/10.7554/elife.30867.020
Autor:
Daniel W. Gerlich, Matthias Samwer
Publikováno v:
Nature. 561:467-468
Chromosomes can exist outside the nucleus in rupture-prone structures called micronuclei. It emerges that micronuclei are fragile because their outer layer lacks some nuclear-envelope components. Micronuclei are fragile because they lack some nuclear
Autor:
Andreas Wernitznig, Dorothea Rudolph, Matthias Samwer, Norbert Schweifer, Francesca Trapani, Tobias Wunberg, Heribert Arnhof, Teakyu Lee, John L. Sensintaffar, Edward T. Olejniczak, Cyril H. Benes, Stephen W. Fesik, Norbert Kraut
Publikováno v:
Cancer Research. 79:3987-3987
MCL1, an anti-apoptotic member of the BCL-2 family of proteins, is a key regulator of cancer cell survival and a known resistance factor to anti-cancer drugs, making it a highly desirable target for therapeutic intervention. Recently several MCL1 inh
Autor:
Henning Urlaub, Heinz-Jürgen Dehne, Daniel W. Gerlich, Felix Spira, Dirk Görlich, Martin Kollmar, Matthias Samwer
Publikováno v:
The EMBO Journal
EMBO Journal
EMBO Journal
Nuclei of Xenopus laevis oocytes grow 100 000-fold larger in volume than a typical somatic nucleus and require an unusual intranuclear F-actin scaffold for mechanical stability. We now developed a method for mapping F-actin interactomes and identifie