Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Matthias Rieckher"'
Autor:
Carla Umansky, Agustín E. Morellato, Matthias Rieckher, Marco A. Scheidegger, Manuela R. Martinefski, Gabriela A. Fernández, Oleg Pak, Ksenia Kolesnikova, Hernán Reingruber, Mariela Bollini, Gerry P. Crossan, Natascha Sommer, María Eugenia Monge, Björn Schumacher, Lucas B. Pontel
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)
Formaldehyde (FA) is known to exert cytotoxicity through DNA damage. Here, the authors show that FA also triggers cellular redox imbalance by reacting with glutathione (GSH), and that FA cytotoxicity is prevented by GSH synthesis and by ADH5, an enzy
Externí odkaz:
https://doaj.org/article/653aae910d4d4b0192f151bf36477da9
Publikováno v:
Cell Reports, Vol 25, Iss 1, Pp 199-211.e6 (2018)
Summary: Aging is accompanied by a pervasive collapse of proteostasis, while reducing general protein synthesis promotes longevity across taxa. Here, we show that the eIF4E isoform IFE-2 is increasingly sequestered in mRNA processing (P) bodies durin
Externí odkaz:
https://doaj.org/article/8a670332632e4849a8443f2ed12a9bf7
Publikováno v:
Bio-Protocol, Vol 7, Iss 19 (2017)
Microinjection is the most frequently used tool for genetic transformation of the nematode Caenorhabditis elegans, facilitating the transgenic expression of genes, genome editing by the clustered regularly interspersed short palindromic repeats (CRIS
Externí odkaz:
https://doaj.org/article/b4ad61e3f9c14fb7a87f7d048de5794c
Publikováno v:
Bio-Protocol, Vol 7, Iss 2 (2017)
Eukaryotic cells contain various types of cytoplasmic, non-membrane bound ribonucleoprotein (RNP) granules that consist of non-translating mRNAs and a versatile set of associated proteins. One prominent type of RNP granules is Processing bodies (P bo
Externí odkaz:
https://doaj.org/article/f6234b7e7bc84da999dc1c69eb709e26
Autor:
Matthias Rieckher, Ilias Kyparissidis-Kokkinidis, Athanasios Zacharopoulos, Georgios Kourmoulakis, Nektarios Tavernarakis, Jorge Ripoll, Giannis Zacharakis
Publikováno v:
PLoS ONE, Vol 10, Iss 5, p e0127869 (2015)
We describe a customizable and cost-effective light sheet microscopy (LSM) platform for rapid three-dimensional imaging of protein dynamics in small model organisms. The system is designed for high acquisition speeds and enables extended time-lapse i
Externí odkaz:
https://doaj.org/article/466c48916dcb41669d2239da9b75e3cd
Publikováno v:
PLoS ONE, Vol 6, Iss 4, p e18963 (2011)
We describe a versatile optical projection tomography system for rapid three-dimensional imaging of microscopic specimens in vivo. Our tomographic setup eliminates the in xy and z strongly asymmetric resolution, resulting from optical sectioning in c
Externí odkaz:
https://doaj.org/article/a67dd433d5f946e78f17410f1567a176
Publikováno v:
Trends in Molecular Medicine. 27:907-922
Progeroid syndromes (PSs) are characterized by the premature onset of age-related pathologies. The genetic mutations underlying PSs are functionally linked to genome maintenance and repair, supporting the causative role of DNA damage accumulation in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0378e4b488063f75968ad7022a9db901
https://doi.org/10.1016/j.molmed.2021.06.011
https://doi.org/10.1016/j.molmed.2021.06.011
Autor:
Björn Schumacher, Katarzyna Bozek, Amanda F C Lopes, Aleksandra Trifunovic, Marija Herholz, Matthias Rieckher
Publikováno v:
Nucleic Acids Research
Cockayne syndrome (CS) is a congenital syndrome characterized by growth and mental retardation, and premature ageing. The complexity of CS and mammalian models warrants simpler metazoan models that display CS-like phenotypes that could be studied in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d7ff168e515c37c7b15f10d9e1093a5
http://europepmc.org/articles/PMC7641758
http://europepmc.org/articles/PMC7641758
Autor:
Felix Heider, Ashley B. Williams, Björn Schumacher, Wilhelm Bloch, Matthias Rieckher, Jan-Erik Messling
Publikováno v:
Genetics
Caenorhabditis elegans possesses a rudimentary innate immune response that serves as a model for various aspects of the human innate immune response. To date, a nematode response to pathogenic cytoplasmic DNA has not been identified... Innate immune
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc11d1d72196fd179d418036d90955f6
https://doi.org/10.1534/genetics.119.302422
https://doi.org/10.1534/genetics.119.302422
Autor:
Gabriela Araceli Fernandez, Yan Wei, Manuela Romina Martinefski, Bj oumlrn Schumacher, Lucas B. Pontel, Mariela Bollini, Matthias Rieckher, Ismene Karakasilioti, Ksenia Kolesnikova, Carla Umansky, Agust iacuten Morellato, Rongqiao He, Hern aacuten Reingruber, Anna Juliane Vesting, Marco Scheidegger, Mar iacutea Eugenia Monge
Formaldehyde (FA) is a ubiquitous endogenous and environmental metabolite that is thought to exert cytotoxicity through DNA and DNA-protein crosslinking. We show here that FA can cause cellular damage beyond genotoxicity by triggering oxidative stres
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ceecfff427a46708bce9587a4b393ec7
https://doi.org/10.1101/2020.05.14.090738
https://doi.org/10.1101/2020.05.14.090738
