Zobrazeno 1 - 10
of 44
pro vyhledávání: '"Matthias Regner"'
Publikováno v:
PLoS ONE, Vol 7, Iss 9, p e44834 (2012)
Japanese encephalitis is a severe central nervous system (CNS) inflammatory disease caused by the mosquito-borne flavivirus, Japanese encephalitis virus (JEV). In the current study we have investigated the immune responses against JEV in mice lacking
Externí odkaz:
https://doaj.org/article/dbae2c3ac1b14bd2900d0d3e628770bd
Publikováno v:
PLoS ONE, Vol 6, Iss 8, p e23252 (2011)
NK cells kill target cells mainly via exocytosis of granules containing perforin (perf) and granzymes (gzm). In vitro, gzm delivery into the target cell cytosol results in apoptosis, and induction of apoptosis is severely impaired in the absence of g
Externí odkaz:
https://doaj.org/article/c3361fd38f2b47f5b9389d6227a5ec61
Autor:
Yoichi Furuya, Jennifer Chan, En-Chi Wan, Aulikki Koskinen, Kerrilyn R Diener, John D Hayball, Matthias Regner, Arno Müllbacher, Mohammed Alsharifi
Publikováno v:
PLoS ONE, Vol 6, Iss 10, p e25765 (2011)
BACKGROUND: We have shown previously in mice, that infection with live viruses, including influenza/A and Semliki Forest virus (SFV), induces systemic partial activation of lymphocytes, characterized by cell surface expression of CD69 and CD86, but n
Externí odkaz:
https://doaj.org/article/ad2e61aeaf4142dda6b8c7ea03a54c3a
Autor:
Julián Pardo, Eva María Gálvez, Aulikki Koskinen, Markus M Simon, Mario Lobigs, Matthias Regner, Arno Müllbacher
Publikováno v:
PLoS ONE, Vol 4, Iss 10, p e7512 (2009)
BACKGROUND: Ectromelia virus is a natural mouse pathogen, causing mousepox. The cytotoxic T (Tc) cell granule serine-protease, granzyme B, is important for its control, but the underlying mechanism is unknown. Using ex vivo virus immune Tc cells, we
Externí odkaz:
https://doaj.org/article/65498792f83d4665b5297cf371e14c8d
Autor:
Mohammed Alsharifi, Yoichi Furuya, Timothy R Bowden, Mario Lobigs, Aulikki Koskinen, Matthias Regner, Lee Trinidad, David B Boyle, Arno Müllbacher
Publikováno v:
PLoS ONE, Vol 4, Iss 4, p e5336 (2009)
BACKGROUND: Influenza A (flu) virus causes significant morbidity and mortality worldwide, and current vaccines require annual updating to protect against the rapidly arising antigenic variations due to antigenic shift and drift. In fact, current subu
Externí odkaz:
https://doaj.org/article/d7df0ff886154443a74a919693951cdf
Autor:
Ava E Carter, Matthias Regner
Publikováno v:
Psychiatry Research Case Reports. 1:100079
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::39a14e4a4319206d793768a4e0cfb73f
https://doi.org/10.1016/j.psycr.2022.100079
https://doi.org/10.1016/j.psycr.2022.100079
Autor:
Matthias Regner, Katrina Louise Scarff, Monica Devi Prakash, Carolina R. Melo-Silva, Aulikki Koskinen, Arno Müllbacher, Alexandra Rizzitelli, Jennii Luu, Matthew Mangan, Catherina H. Bird, Phillip I. Bird
Publikováno v:
Immunology & Cell Biology. 95:884-894
Intracellular serpins are proposed to inactivate proteases released from lysosome-related organelles into the host cell interior, preventing cell death. Serpinb9 opposes the immune cytotoxic protease, granzyme B, and in a number of settings protects
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc01edb63dbf69bf11e623810448c815
https://doi.org/10.1038/icb.2017.59
https://doi.org/10.1038/icb.2017.59
Autor:
Mario Lobigs, Arno Müllbacher, Aulikki Koskinen, Matthias Regner, Carolina R. Melo-Silva, David C. Tscharke
Publikováno v:
Virus Research. 228:61-65
Mousepox is caused by the orthopoxvirus ectromelia virus (ECTV), and is thought to be transmitted via skin abrasions. We studied the ECTV virulence factor N1 following subcutaneous infection of mousepox-susceptible BALB/c mice. In this model, ECTV la
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eaf2665d3889115f42128b02c9d16cd6
https://doi.org/10.1016/j.virusres.2016.11.017
https://doi.org/10.1016/j.virusres.2016.11.017
Autor:
Paulus Mrass, Stephen J. Turner, Bosco K. Ho, Marcia A. Munoz, Matthew R. Olson, Philip L. Tong, Monica Devi Prakash, Aulikki Koskinen, Phillip I. Bird, Rohit Jain, Oded Kleifeld, Wolfgang Weninger, Matthias Regner
Publikováno v:
Immunity. 41:960-972
SummaryGranzyme B (GzmB) is a protease with a well-characterized intracellular role in targeted destruction of compromised cells by cytotoxic lymphocytes. However, GzmB also cleaves extracellular matrix components, suggesting that it influences the i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e485919d8d92afe1d02865775c763230
https://doi.org/10.1016/j.immuni.2014.11.012
https://doi.org/10.1016/j.immuni.2014.11.012
Publikováno v:
European Journal of Immunology. 43:1789-1798
Japanese encephalitis, caused by infection with the neurotropic flavivirus, Japanese encephalitis virus (JEV), is among the most important viral encephalitides in Asia. While previous studies established an essential role of Ab and type I IFN, it is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6ac9da0debbf0d91250cdccc2cc4e343
https://doi.org/10.1002/eji.201243152
https://doi.org/10.1002/eji.201243152