Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Matthias Rüdt"'
Publikováno v:
Frontiers in Bioengineering and Biotechnology, Vol 12 (2024)
Chemometric modeling for spectral data is considered a key technology in biopharmaceutical processing to realize real-time process control and release testing. Machine learning (ML) models have been shown to increase the accuracy of various spectral
Externí odkaz:
https://doaj.org/article/1d6deebc14b142d98d4769d585f3ad23
Publikováno v:
Analytical and Bioanalytical Chemistry, 415 (5), 841–854
Monitoring the protein concentration and buffer composition during the Ultrafiltration/Diafiltration (UF/DF) step enables the further automation of biopharmaceutical production and supports Real-time Release Testing (RTRT). Previously, in-line Ultrav
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e03b45a9fb881ad3fba84c42c2297545
Autor:
Jürgen Hubbuch, Juliane Diehm, Laura Rolinger, Jessica Chow-Hubbertz, Martin Heitmann, Matthias Rüdt, Stefan Schleper
Publikováno v:
Analytical and Bioanalytical Chemistry. 412:2123-2136
Ultrafiltration/diafiltration (UF/DF) plays an important role in the manufacturing of biopharmaceuticals. Monitoring critical process parameters and quality attributes by process analytical technology (PAT) during those steps can facilitate process d
Publikováno v:
Journal of Biotechnology. 288:15-22
The conjugation reaction of monoclonal antibodies (mAbs) with small-molecule drugs is a central step during production of antibody-drug conjugates (ADCs). The ability to monitor this step in real time can be advantageous for process understanding and
Publikováno v:
Biotechnology and Bioengineering, 118 (11), 4255-4268
A promising application of Process Analytical Technology to the downstream process of monoclonal antibodies (mAbs) is the monitoring of the Protein A load phase as its control promises economic benefits. Different spectroscopic techniques have been e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f2c7f5438d266abad64163a99220089
https://publikationen.bibliothek.kit.edu/1000137046
https://publikationen.bibliothek.kit.edu/1000137046
Publikováno v:
Biotechnology & bioengineering, 118 (2), 905-917
Real‐time monitoring and control of protein A capture steps by process analytical technologies (PATs) promises significant economic benefits due to the improved usage of the column's binding capacity, by eliminating time‐consuming off‐line anal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48b886acecfb0df3e562b453a32a7a6d
Publikováno v:
Analytical and bioanalytical chemistry, 412 (9), 2047–2064
Analytical and Bioanalytical Chemistry
Analytical and Bioanalytical Chemistry
As competition in the biopharmaceutical market gets keener due to the market entry of biosimilars, process analytical technologies (PATs) play an important role for process automation and cost reduction. This article will give a general overview and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37164ce21c2b3f45850e4797555d27b9
Publikováno v:
Journal of Chromatography A. 1627:461420
Monitoring preparative protein chromatographic steps by in-line spectroscopic tools or fraction analytics results in medium or large sized data matrices. Multivariate Curve Resolution (MCR) serve to compute or to estimate the concentration values of
Publikováno v:
Biotechnology and Bioengineering
Biotechnology & bioengineering, 116 (6), 1366-1379
Biotechnology & bioengineering, 116 (6), 1366-1379
Virus‐like particles (VLPs) have shown great potential as biopharmaceuticals in the market and in clinics. Nonenveloped, in vivo assembled VLPs are typically disassembled and reassembled in vitro to improve particle stability, homogeneity, and immu
Publikováno v:
Journal of Chromatography A. 1608:460410
PEGylation of biological macromolecules is a well-established strategy to increase circulation half-life, decrease renal clearance and improve biocompatibility. PEGylation is a process in which polyethylene glycol (PEG) is covalently attached to a ta