Zobrazeno 1 - 10
of 44
pro vyhledávání: '"Matthias Pawlowski"'
Autor:
Eliane Luisa Esser, Larissa Lahme, Sebastian Dierse, Raphael Diener, Nicole Eter, Heinz Wiendl, Thomas Duning, Matthias Pawlowski, Julia Krämer, Maged Alnawaiseh
Publikováno v:
Diagnostics, Vol 14, Iss 2, p 211 (2024)
Background: Optical coherence tomography angiography (OCT-A) provides detailed visualization of the perfusion of the vascular network of the eye. While in other forms of dementia, such as Alzheimer’s disease and mild cognitive impairment, reduced r
Externí odkaz:
https://doaj.org/article/a3a06d25a69b44fcb750ab32a327fccd
Autor:
Lisanne Korn, Anna M. Speicher, Christina B. Schroeter, Lukas Gola, Thilo Kaehne, Alexander Engler, Paul Disse, Juncal Fernández-Orth, Júlia Csatári, Michael Naumann, Guiscard Seebohm, Sven G. Meuth, Hans R. Schöler, Heinz Wiendl, Stjepana Kovac, Matthias Pawlowski
Publikováno v:
Redox Biology, Vol 59, Iss , Pp 102597- (2023)
Tauopathies are a major type of proteinopathies underlying neurodegenerative diseases. Mutations in the tau-encoding MAPT-gene lead to hereditary cases of frontotemporal lobar degeneration (FTLD)-tau, which span a wide phenotypic and pathological spe
Externí odkaz:
https://doaj.org/article/5a3136405087409ab46b3e0e9f1c2568
Publikováno v:
Molecular Neurodegeneration, Vol 14, Iss 1, Pp 1-16 (2019)
Abstract Microglia play an essential role for central nervous system (CNS) development and homeostasis and have been implicated in the onset, progression, and clearance of numerous diseases affecting the CNS. Previous in vitro research on human micro
Externí odkaz:
https://doaj.org/article/c68e0d54731946bd9985322a24ea846f
Publikováno v:
Orphanet Journal of Rare Diseases, Vol 13, Iss 1, Pp 1-10 (2018)
Abstract Background Niemann-Pick disease type C (NP-C) is a rare, progressive neurodegenerative disease caused by mutations in the NPC1 or the NPC2 gene. Neurocognitive deficits are common in NP-C, particularly in patients with the adolescent/adult-o
Externí odkaz:
https://doaj.org/article/801966a5d7174563a8308ab0edb66d4c
Autor:
Matthias Pawlowski, Daniel Ortmann, Alessandro Bertero, Joana M. Tavares, Roger A. Pedersen, Ludovic Vallier, Mark R.N. Kotter
Publikováno v:
Stem Cell Reports, Vol 8, Iss 4, Pp 803-812 (2017)
Summary: The isolation or in vitro derivation of many human cell types remains challenging and inefficient. Direct conversion of human pluripotent stem cells (hPSCs) by forced expression of transcription factors provides a potential alternative. Howe
Externí odkaz:
https://doaj.org/article/594d5418d1c949c7875666a1d7d874ca
Autor:
Jens Burchard Schröder, Thomas Marian, Inga Claus, Paul Muhle, Matthias Pawlowski, Heinz Wiendl, Sonja Suntrup-Krueger, Sven G. Meuth, Rainer Dziewas, Tobias Ruck, Tobias Warnecke
Publikováno v:
Frontiers in Neurology, Vol 10 (2019)
Introduction: Although patients with Parkinson's disease (PD) often suffer from oropharyngeal dysphagia, knowledge about the underlying pathophysiological mechanisms is limited. Substance P (SP) is a localization-independent neurotransmitter of the e
Externí odkaz:
https://doaj.org/article/0ff06251072f4afcbc107fa891be8d2b
Autor:
Jens B. Schröder, Matthias Pawlowski, Gerd Meyer zu Hörste, Catharina C. Gross, Heinz Wiendl, Sven G. Meuth, Tobias Ruck, Tobias Warnecke
Publikováno v:
Frontiers in Neurology, Vol 9 (2018)
Background: Parkinson's disease (PD) is a common neurodegenerative disorder. The contribution of the immune system to its pathogenesis remains incompletely understood.Methods: In this study, we performed comprehensive immune cell profiling in the cer
Externí odkaz:
https://doaj.org/article/6dbee490834040cf80fb4d76bbc59397
Publikováno v:
Diagnostics, Vol 7, Iss 3, p 42 (2017)
Alzheimer’s disease is the most common cause of dementia. Over the last three decades, research has advanced dramatically and provided a detailed understanding of the molecular events underlying the pathogenesis of Alzheimer’s disease. In paralle
Externí odkaz:
https://doaj.org/article/0a8da47977af45a68c94b2fb4c829e8e
Autor:
Paul Disse, Isabel Aymanns, Nadine Ritter, Stefan Peischard, Lisanne Korn, Heinz Wiendl, Matthias Pawlowski, Stjepana Kovac, Sven G. Meuth, Thomas Budde, Nathalie Strutz-Seebohm, Bernhard Wünsch, Guiscard Seebohm
Publikováno v:
Biological Chemistry. 404:267-277
N-Methyl-D-aspartate receptors (NMDARs) are central for learning and information processing in the brain. Dysfunction of NMDARs can play a key role in the pathogenesis of neurodegeneration and drug addiction. The development of selective NMDAR modula
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bd0307f42348142a044fd3e9edffb31b
https://doi.org/10.1515/hsz-2022-0216
https://doi.org/10.1515/hsz-2022-0216
Autor:
Lukas Gola, Laura Bierhansl, Nicolas Hummel, Lisanne Korn, Matthias Pawlowski, Manuela Cerina, Petra Hundehege, Thomas Budde, Simone König, Sven G. Meuth, Heinz Wiendl, Stjepana Kovac
Publikováno v:
Free Radical Biology and Medicine. 194:337-346
Hyperexcitability-induced neuronal damage plays a role both in epilepsy as well as in inflammatory brain diseases such as multiple sclerosis (MS) and as such represents an important disease pathway which potentially can be targeted to mitigate neuron
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bcec4e2f092e5c81d185ca2b95f74f2c
https://doi.org/10.1016/j.freeradbiomed.2022.12.010
https://doi.org/10.1016/j.freeradbiomed.2022.12.010