Zobrazeno 1 - 10
of 167
pro vyhledávání: '"Matthias P. Wymann"'
Autor:
Thorsten Schaefer, Nitish Mittal, Hui Wang, Meric Ataman, Silvia Candido, Jonas Lötscher, Sergiy Velychko, Lionel Tintignac, Thomas Bock, Anastasiya Börsch, Jochen Baßler, Tata Nageswara Rao, Jakub Zmajkovic, Sarah Roffeis, Jordan Löliger, Francis Jacob, Alain Dumlin, Christoph Schürch, Alexander Schmidt, Radek C. Skoda, Matthias P. Wymann, Christoph Hess, Hans R. Schöler, Holm Zaehres, Ed Hurt, Mihaela Zavolan, Claudia Lengerke
Publikováno v:
Cell Reports, Vol 43, Iss 10, Pp 114807- (2024)
Summary: Stemness and pluripotency are mediated by transcriptional master regulators that promote self-renewal and repress cell differentiation, among which is the high-mobility group (HMG) box transcription factor SOX2. Dysregulated SOX2 expression,
Externí odkaz:
https://doaj.org/article/3f4435c1df914aa5bdc0b2931130faf7
Autor:
Chiara Borsari, Matthias P. Wymann
Publikováno v:
CHIMIA, Vol 75, Iss 12 (2021)
Phosphoinositide 3-kinase (PI3K) takes a key role in a plethora of physiologic processes and controls cell growth, metabolism, immunity, cardiovascular and neurological function, and more. The discovery of wortmannin as the first potent PI3K inhibito
Externí odkaz:
https://doaj.org/article/547d3946e3974012bb49518fa2b38527
Autor:
Andrew J. Takeda, Timothy J. Maher, Yu Zhang, Stephen M. Lanahan, Molly L. Bucklin, Susan R. Compton, Paul M. Tyler, William A. Comrie, Makoto Matsuda, Kenneth N. Olivier, Stefania Pittaluga, Joshua J. McElwee, Debra A. Long Priel, Douglas B. Kuhns, Roger L. Williams, Peter J. Mustillo, Matthias P. Wymann, V. Koneti Rao, Carrie L. Lucas
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
Causally linking a mutation to clinical phenotypes in rare hereditary diseases is both challenging and illuminating. Here the authors identify PI3Kɣ mutations in a patient with immune dysregulation, and recapitulate the phenotypes in PI3Kɣ-deficien
Externí odkaz:
https://doaj.org/article/e5661652c92a434e8616129d00386c3f
Autor:
Julie R. Jin, Elena Gogvadze, Ana R. Xavier, Thomas Bohnacker, Jan Voelzmann, Matthias P. Wymann
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
Mast cells are the major effector cells in immunoglobulin E (IgE)-mediated allergy. The high affinity IgE receptor FcεRI, as well as G protein-coupled receptors (GPCRs) on the mast cell surface signals to phosphoinositide 3-kinase γ (PI3Kγ) to ini
Externí odkaz:
https://doaj.org/article/c8269d02e3da4ce8a13fc6f8b59d90e3
Autor:
Thomas Bohnacker, Andrea E. Prota, Florent Beaufils, John E. Burke, Anna Melone, Alison J. Inglis, Denise Rageot, Alexander M. Sele, Vladimir Cmiljanovic, Natasa Cmiljanovic, Katja Bargsten, Amol Aher, Anna Akhmanova, J. Fernando Díaz, Doriano Fabbro, Marketa Zvelebil, Roger L. Williams, Michel O. Steinmetz, Matthias P. Wymann
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
Buparlisib/BKM120 is in phase 3 clinical trials as a phosphoinositide 3-kinase (PI3K) inhibitor. Here, Bohnackeret al. combine chemical biology and structural biology approaches to segregate BKM120’s biological actions, and suggest that it causes m
Externí odkaz:
https://doaj.org/article/a5212909a4a7490db4d79600c172c822
Autor:
Luca Aresu, Serena Ferraresso, Laura Marconato, Luciano Cascione, Sara Napoli, Eugenio Gaudio, Ivo Kwee, Chiara Tarantelli, Andrea Testa, Chiara Maniaci, Alessio Ciulli, Petra Hillmann, Thomas Bohnacker, Matthias P. Wymann, Stefano Comazzi, Massimo Milan, Fulvio Riondato, Giulia Dalla Rovere, Mery Giantin, Diana Giannuzzi, Francesco Bertoni
Publikováno v:
Haematologica, Vol 104, Iss 6 (2019)
Externí odkaz:
https://doaj.org/article/df8e7002c3f442f0a88084a02154e353
Autor:
Joshua J. Anzinger, Janet Chang, Qing Xu, Manoj K. Barthwal, Thomas Bohnacker, Matthias P. Wymann, Howard S. Kruth
Publikováno v:
Journal of Lipid Research, Vol 53, Iss 1, Pp 34-42 (2012)
Accumulation of cholesterol by macrophage uptake of LDL is a key event in the formation of atherosclerotic plaques. Previous research has shown that granulocyte-macrophage colony-stimulating factor (GM-CSF) is present in atherosclerotic plaques and p
Externí odkaz:
https://doaj.org/article/da1b19f23bc64e249a406cf4bd806737
Autor:
Manoj K Rathinaswamy, Zied Gaieb, Kaelin D Fleming, Chiara Borsari, Noah J Harris, Brandon E Moeller, Matthias P Wymann, Rommie E Amaro, John E Burke
Publikováno v:
eLife, Vol 10 (2021)
Class I Phosphoinositide 3-kinases (PI3Ks) are master regulators of cellular functions, with the class IB PI3K catalytic subunit (p110γ) playing key roles in immune signalling. p110γ is a key factor in inflammatory diseases and has been identified
Externí odkaz:
https://doaj.org/article/7f784cecc93e43a98a6ad064bf0019ce
Autor:
Chiara Borsari, Matthias P. Wymann, Pierre Boulay, Claudio Meyer, Uros Stojiljkovic, Paul Hebeisen, Denise Rageot
Publikováno v:
Synthesis. 55:499-509
Morpholine is a heterocyclic moiety that is widely used in medicinal chemistry as a building block. It has unique physicochemical properties, as it can improve both pharmacokinetic and pharmacodynamic properties of active pharmaceutical ingredients.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1bae8640ab8332b242deef841eededf4
https://doi.org/10.1055/a-1915-7794
https://doi.org/10.1055/a-1915-7794
Autor:
Matthias P. Wymann, Sauveur-Michel Maira, Bernd Giese, Carlos Garcia-Echeverria, Frédéric Stauffer, Vladimir Cmiljanovic, Christian Schnell, Thomas Bohnacker, Ann C. Mertz, Dominik Erhart, Romina Marone
Supplementary Data from Targeting Melanoma with Dual Phosphoinositide 3-Kinase/Mammalian Target of Rapamycin Inhibitors
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9260b847243d0cd1ef1c54f287784d03
https://doi.org/10.1158/1541-7786.22519242.v1
https://doi.org/10.1158/1541-7786.22519242.v1
