Zobrazeno 1 - 10
of 99
pro vyhledávání: '"Matthias P. Müller"'
Autor:
Lena Quambusch, Laura Depta, Ina Landel, Melissa Lubeck, Tonia Kirschner, Jonas Nabert, Niklas Uhlenbrock, Jörn Weisner, Michael Kostka, Laura M. Levy, Carsten Schultz-Fademrecht, Franziska Glanemann, Kristina Althoff, Matthias P. Müller, Jens T. Siveke, Daniel Rauh
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
Elucidating specific effects of protein kinase Akt isoforms remains challenging. Here, the authors establish an Akt isoform-dependent cellular model system and use it, together with X-ray crystallography and structure-based ligand design, to develop
Externí odkaz:
https://doaj.org/article/e9d5b9b56b6e4d8f9a3489c70c876e8e
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-11 (2017)
Abstract Simple reversible competitive inhibition of nucleotide binding of GTP to Ras family GTPases has long been recognized as an unlikely approach to manipulating the activity of such proteins for experimental or therapeutic purposes. This is due
Externí odkaz:
https://doaj.org/article/2905962a45d8475ebe1fcab659106648
Autor:
Philipp J. Vetter, Thomas Reisser, Maximilian G. Hirsch, Tommaso Calarco, Felix Motzoi, Fedor Jelezko, Matthias M. Müller
Publikováno v:
npj Quantum Information, Vol 10, Iss 1, Pp 1-12 (2024)
Abstract A recurring challenge in quantum science and technology is the precise control of their underlying dynamics that lead to the desired quantum operations, often described by a set of quantum gates. These gates can be subject to application-spe
Externí odkaz:
https://doaj.org/article/a0cbbd6394ac42bf8765cf1370f48e8d
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-16 (2022)
Abstract Accurate manipulations of an open quantum system require a deep knowledge of its controllability properties and the information content of the implemented control fields. By using tools of information and quantum optimal control theory, we p
Externí odkaz:
https://doaj.org/article/59f5f1ecf1ac4383bb64757d860cdb29
Autor:
Roland Weierstall-Pust, Thomas Schnell, Philipp Heßmann, Michael Feld, Max Höfer, Anna Plate, Matthias J. Müller
Publikováno v:
BMC Public Health, Vol 22, Iss 1, Pp 1-10 (2022)
Abstract Background Climate change, the Covid-19 pandemic, and the Ukraine crisis are considered unprecedented global stressors, potentially associated with serious health consequences. However, simultaneous effects of these stressors are not yet und
Externí odkaz:
https://doaj.org/article/cc5ccac949ed435ab1a76326aade5115
Autor:
Katja Eildermann, Sabrina Goldmann, Ulrich Krause, David Backhoff, Friedrich A. Schöndube, Thomas Paul, Thomas Quentin, Matthias J. Müller
Publikováno v:
Journal of Cardiovascular Development and Disease, Vol 10, Iss 11, p 466 (2023)
Background: Sex-specific differences in heart disease outcomes are influenced by the levels of the steroid hormones, estrogen and testosterone. While the roles of estrogen receptors in cardiac disease are well-studied in animals and humans, respectiv
Externí odkaz:
https://doaj.org/article/08e64f08991845ef9b71be5c99ff9f84
Autor:
Lisa Goebel, Tonia Kirschner, Sandra Koska, Amrita Rai, Petra Janning, Stefano Maffini, Helge Vatheuer, Paul Czodrowski, Roger S Goody, Matthias P Müller, Daniel Rauh
Publikováno v:
eLife, Vol 12 (2023)
Mutations within Ras proteins represent major drivers in human cancer. In this study, we report the structure-based design, synthesis, as well as biochemical and cellular evaluation of nucleotide-based covalent inhibitors for KRasG13C, an important o
Externí odkaz:
https://doaj.org/article/a1d132d50aee4a898fe7a71dc2e28751
Publikováno v:
Frontiers in Endocrinology, Vol 13 (2022)
IntroductionA mathematical model of the pituitary-thyroid feedback loop is extended to deepen the understanding of the Allan-Herndon-Dudley syndrome (AHDS). The AHDS is characterized by unusual thyroid hormone concentrations and a mutation in the SLC
Externí odkaz:
https://doaj.org/article/fe656a4ae7884fddaf9c4344c9a9204d
Publikováno v:
NeuroImage, Vol 264, Iss , Pp 119759- (2022)
There is much debate about the neural mechanisms that achieve suppression of salient distracting stimuli during visual search. The proactive suppression hypothesis asserts that if exposed to the same distractors repeatedly, these stimuli are actively
Externí odkaz:
https://doaj.org/article/8ce0241729b0468e9f99b19aa9774b71
Publikováno v:
Frontiers in Endocrinology, Vol 13 (2022)
In this paper, we address the problem of optimal thyroid hormone replacement strategy development for hypothyroid patients. This is challenging for the following reasons. First, it is difficult to determine the correct dosage leading to normalized se
Externí odkaz:
https://doaj.org/article/af1aa408dd9d467b93002adcb122b09b