Zobrazeno 1 - 10
of 80
pro vyhledávání: '"Matthias P A Ebert"'
Nuclear pore protein POM121 regulates subcellular localization and transcriptional activity of PPARγ
Autor:
Yanxiong Yu, Mohammad S. Farooq, Sabine Eberhart Meessen, Yidan Jiang, Dominik Kato, Tianzuo Zhan, Christel Weiss, Rony Seger, Wei Kang, Xiang Zhang, Jun Yu, Matthias P. A. Ebert, Elke Burgermeister
Publikováno v:
Cell Death and Disease, Vol 15, Iss 1, Pp 1-15 (2024)
Abstract Manipulation of the subcellular localization of transcription factors by preventing their shuttling via the nuclear pore complex (NPC) emerges as a novel therapeutic strategy against cancer. One transmembrane component of the NPC is POM121,
Externí odkaz:
https://doaj.org/article/6bed8f0ab6084ad89c70dd3400a646df
Autor:
Ivana Hitkova, Gang Yuan, Florian Anderl, Markus Gerhard, Thomas Kirchner, Simone Reu, Christoph Röcken, Claus Schäfer, Roland M Schmid, Roger Vogelmann, Matthias P A Ebert, Elke Burgermeister
Publikováno v:
PLoS Pathogens, Vol 9, Iss 4, p e1003251 (2013)
Caveolin-1 (Cav1) is a scaffold protein and pathogen receptor in the mucosa of the gastrointestinal tract. Chronic infection of gastric epithelial cells by Helicobacter pylori (H. pylori) is a major risk factor for human gastric cancer (GC) where Cav
Externí odkaz:
https://doaj.org/article/5f910b0d56434d33a6ed47ef642b0a0f
Autor:
Marc Tänzer, Benjamin Balluff, Jürgen Distler, Kari Hale, Andreas Leodolter, Christoph Röcken, Bela Molnar, Roland Schmid, Catherine Lofton-Day, Tibor Schuster, Matthias P A Ebert
Publikováno v:
PLoS ONE, Vol 5, Iss 2, p e9061 (2010)
BACKGROUND:Screening for colorectal cancer (CRC) has shown to reduce cancer-related mortality, however, acceptance and compliance to current programmes are poor. Developing new, more acceptable non-invasive tests for the detection of cancerous and pr
Externí odkaz:
https://doaj.org/article/8683002a27be47fb9db3f6eba069df03
Autor:
Barbara Ingold, Eva Simon, Ute Ungethüm, Ralf-Jürgen Kuban, Berit M Müller, Amelie Lupp, Ulf Neumann, Matthias P A Ebert, Carsten Denkert, Wilko Weichert, Stefan Schulz, Christoph Röcken
Publikováno v:
PLoS ONE, Vol 5, Iss 4, p e10087 (2010)
BACKGROUND: G-protein-coupled receptors (GPCRs) are prime candidates for novel cancer prevention and treatment strategies. We searched for differentially expressed GPCRs in node positive gastric carcinomas. METHODOLOGY/PRINCIPAL FINDINGS: Differentia
Externí odkaz:
https://doaj.org/article/c27f9da7364b45d08f86220941190059
Autor:
Helen R Valentine, P W Bishop, Catharine M L West, I. Welch, Susan Pritchard, Patricia M Price, Ewen A. Griffiths, N Whitchelo, Matthias P. A. Ebert
Publikováno v:
British Journal of Cancer
Hypoxia-inducible factor-1 (HIF-1)alpha expression was studied in the gastric carcinogenesis sequence and as a prognostic factor in surgically resected gastric and gastro-oesophageal junction tumours. Protein expression was examined using immunohisto
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::81ca393fab9919e1d561c633c796e425
https://doi.org/10.1038/sj.bjc.6603524
https://doi.org/10.1038/sj.bjc.6603524
Autor:
Christoph Röcken, Sören O. Deininger, Juliane Hoffmann, Dagmar Niemeyer, Jörg Sauer, Claudia Knippig, Thomas Wex, Wolfgang Albrecht, Matthias P. A. Ebert, Peter Malfertheiner
Publikováno v:
Journal of Proteome Research. 5:2152-2158
Gastric cancer is the second most common malignancy and prognosis remains dismal. The reasons for the poor prognosis are the lack of sensitive serum markers for early detection and screening of high-risk individuals as well as the limited treatment o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce26236cffeca747ec0c783c47343121
https://doi.org/10.1021/pr060011c
https://doi.org/10.1021/pr060011c
Autor:
Stefan Kahl, Matthias P. A. Ebert, Barbara Nitsche, C. Hosius, Jie Chen, Christoph Röcken, Peter Malfertheiner, Harald Gschaidmeier
Publikováno v:
Cancer Letters. 233:328-337
Imatinib targets KIT and platelet-derived growth factor receptors (PDGFR) and is highly effective in the treatment of CML and GIST patients. Pancreatic cancers express KIT and PDGFRs. Therefore, 26 patients with unresectable pancreatic cancer were ra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1500f6c9c8bf1d51331094db43ed2201
https://doi.org/10.1016/j.canlet.2005.03.027
https://doi.org/10.1016/j.canlet.2005.03.027
Autor:
Lori Tonnes-Priddy, Peter Malfertheiner, Hans-Ulrich Schulz, Jie Chen, Juliane Hoffmann, Matthias P. A. Ebert, Joe Lograsso, Suzanne Mooney, Christoph Röcken, Catherine Lofton-Day
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 7, Iss 8, Pp 771-778 (2005)
The role of promoter methylation in the process of cancer cell metastasis has, however, not yet been studied. Recently, methylation of the TPEF (transmembrane protein containing epidermal growth factor and follistatin domain) gene was reported in hum
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8abedddcbe0f13d9f71a85dd211430d6
http://www.sciencedirect.com/science/article/pii/S1476558605801095
http://www.sciencedirect.com/science/article/pii/S1476558605801095
Autor:
Matthias Pross, Marie-Laure Fogeron, Hermann Lage, Peter Malfertheiner, Hans-Ulrich Schulz, Albert Roessner, Sabine Krüger, Matthias P. A. Ebert, Jie Chen, Steffen Heim, Stephanie Lamer, Christoph Röcken
Publikováno v:
PROTEOMICS. 5:1693-1704
We aimed to validate an analytical approach based on proteomics on gastric cancer specimens for the identification of new putative diagnostic or prognostic markers. Primary screening was performed on gastrectomy specimens obtained from ten consecutiv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1328716786426fd505b9e5ac2bed83e4
https://doi.org/10.1002/pmic.200401030
https://doi.org/10.1002/pmic.200401030
Autor:
Marc A. Reymond, Peter Malfertheiner, Jörn Meuer, Christoph Röcken, Matthias P. A. Ebert, Thomas Buschmann, Volker Seibert, Stephanie Lamer
Publikováno v:
Journal of Proteome Research. 4:586-590
Gastric cancer mortality is second only to lung cancer, and its prognosis is dismal. Using surface-enhanced laser desorption/ionization-time-of-flight mass spectrometry, we previously identified a single best mass, which could separate gastric cancer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c13181ed4768aa7ee20ff4ebde124a11
https://doi.org/10.1021/pr049771i
https://doi.org/10.1021/pr049771i