Zobrazeno 1 - 10
of 80
pro vyhledávání: '"Matthias P A, Ebert"'
Nuclear pore protein POM121 regulates subcellular localization and transcriptional activity of PPARγ
Autor:
Yanxiong Yu, Mohammad S. Farooq, Sabine Eberhart Meessen, Yidan Jiang, Dominik Kato, Tianzuo Zhan, Christel Weiss, Rony Seger, Wei Kang, Xiang Zhang, Jun Yu, Matthias P. A. Ebert, Elke Burgermeister
Publikováno v:
Cell Death and Disease, Vol 15, Iss 1, Pp 1-15 (2024)
Abstract Manipulation of the subcellular localization of transcription factors by preventing their shuttling via the nuclear pore complex (NPC) emerges as a novel therapeutic strategy against cancer. One transmembrane component of the NPC is POM121,
Externí odkaz:
https://doaj.org/article/6bed8f0ab6084ad89c70dd3400a646df
Publikováno v:
Canadian Journal of Gastroenterology and Hepatology, Vol 2020 (2020)
Preventive transhepatic tract embolisation (PTTE) after percutaneous biliary intervention (PBI) may reduce adverse events. The aim of this systematic review was to analyse feasibility, safety, and efficacy of PTTE with different embolic agents. A sys
Externí odkaz:
https://doaj.org/article/d6e5d18443ad4cfba3d9990f1ce182c8
Autor:
Dominiek Smeets, Ian S. Miller, Darran P. O’Connor, Sudipto Das, Bruce Moran, Bram Boeckx, Timo Gaiser, Johannes Betge, Ana Barat, Rut Klinger, Nicole C. T. van Grieken, Chiara Cremolini, Hans Prenen, Massimiliano Mazzone, Jeroen Depreeuw, Orna Bacon, Bozena Fender, Joseph Brady, Bryan T. Hennessy, Deborah A. McNamara, Elaine Kay, Henk M. Verheul, Neerincx Maarten, William M. Gallagher, Verena Murphy, Jochen H. M. Prehn, Miriam Koopman, Cornelis J. A. Punt, Fotios Loupakis, Matthias P. A. Ebert, Bauke Ylstra, Diether Lambrechts, Annette T. Byrne
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-16 (2018)
Increased copy number alterations, indicative of chromosomal instability, is associated with poor cancer outcome. Here, metastatic colorectal cancer patients displaying intermediate-high CIN associate with improved outcome following chemotherapy and
Externí odkaz:
https://doaj.org/article/d17fc441244b44c587907023fe2c93dd
Autor:
Haristi Gaitantzi, Julius Karch, Lena Germann, Chen Cai, Vanessa Rausch, Emrullah Birgin, Nuh Rahbari, Tatjana Seitz, Claus Hellerbrand, Courtney König, Hellmut G. Augustin, Carolin Mogler, Carolina de la Torre, Norbert Gretz, Timo Itzel, Andreas Teufel, Matthias P. A. Ebert, Katja Breitkopf-Heinlein
Publikováno v:
Cells, Vol 9, Iss 3, p 617 (2020)
It was previously shown that Bone Morphogenetic Protein (BMP)-9 is constitutively produced and secreted by hepatic stellate cells (HSC). Upon acute liver damage, BMP-9 expression is transiently down-regulated and blocking BMP-9 under conditions of ch
Externí odkaz:
https://doaj.org/article/1aa51eca60e245e4af3f0a6e590e9b8a
Autor:
Tobias Gutting, Christian A. Weber, Philip Weidner, Frank Herweck, Sarah Henn, Teresa Friedrich, Shuiping Yin, Julia Kzhyshkowska, Timo Gaiser, Klaus-Peter Janssen, Wolfgang Reindl, Matthias P. A. Ebert, Elke Burgermeister
Publikováno v:
OncoImmunology, Vol 7, Iss 5 (2018)
To identify novel hubs for cancer immunotherapy, we generated C57BL/6J mice with concomitant deletion of the drugable transcription factor PPARγ and transgenic overexpression of the mutant KRASG12V oncogene in enterocytes. Animals developed epitheli
Externí odkaz:
https://doaj.org/article/4af5172de420432182bd5a1936ffaaae
Autor:
Ivana Hitkova, Gang Yuan, Florian Anderl, Markus Gerhard, Thomas Kirchner, Simone Reu, Christoph Röcken, Claus Schäfer, Roland M Schmid, Roger Vogelmann, Matthias P A Ebert, Elke Burgermeister
Publikováno v:
PLoS Pathogens, Vol 9, Iss 4, p e1003251 (2013)
Caveolin-1 (Cav1) is a scaffold protein and pathogen receptor in the mucosa of the gastrointestinal tract. Chronic infection of gastric epithelial cells by Helicobacter pylori (H. pylori) is a major risk factor for human gastric cancer (GC) where Cav
Externí odkaz:
https://doaj.org/article/5f910b0d56434d33a6ed47ef642b0a0f
Autor:
Marc Tänzer, Benjamin Balluff, Jürgen Distler, Kari Hale, Andreas Leodolter, Christoph Röcken, Bela Molnar, Roland Schmid, Catherine Lofton-Day, Tibor Schuster, Matthias P A Ebert
Publikováno v:
PLoS ONE, Vol 5, Iss 2, p e9061 (2010)
BACKGROUND:Screening for colorectal cancer (CRC) has shown to reduce cancer-related mortality, however, acceptance and compliance to current programmes are poor. Developing new, more acceptable non-invasive tests for the detection of cancerous and pr
Externí odkaz:
https://doaj.org/article/8683002a27be47fb9db3f6eba069df03
Autor:
Barbara Ingold, Eva Simon, Ute Ungethüm, Ralf-Jürgen Kuban, Berit M Müller, Amelie Lupp, Ulf Neumann, Matthias P A Ebert, Carsten Denkert, Wilko Weichert, Stefan Schulz, Christoph Röcken
Publikováno v:
PLoS ONE, Vol 5, Iss 4, p e10087 (2010)
BACKGROUND: G-protein-coupled receptors (GPCRs) are prime candidates for novel cancer prevention and treatment strategies. We searched for differentially expressed GPCRs in node positive gastric carcinomas. METHODOLOGY/PRINCIPAL FINDINGS: Differentia
Externí odkaz:
https://doaj.org/article/c27f9da7364b45d08f86220941190059
Autor:
Helen R Valentine, P W Bishop, Catharine M L West, I. Welch, Susan Pritchard, Patricia M Price, Ewen A. Griffiths, N Whitchelo, Matthias P. A. Ebert
Publikováno v:
British Journal of Cancer
Hypoxia-inducible factor-1 (HIF-1)alpha expression was studied in the gastric carcinogenesis sequence and as a prognostic factor in surgically resected gastric and gastro-oesophageal junction tumours. Protein expression was examined using immunohisto
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::81ca393fab9919e1d561c633c796e425
https://doi.org/10.1038/sj.bjc.6603524
https://doi.org/10.1038/sj.bjc.6603524
Autor:
Christoph Röcken, Sören O. Deininger, Juliane Hoffmann, Dagmar Niemeyer, Jörg Sauer, Claudia Knippig, Thomas Wex, Wolfgang Albrecht, Matthias P. A. Ebert, Peter Malfertheiner
Publikováno v:
Journal of Proteome Research. 5:2152-2158
Gastric cancer is the second most common malignancy and prognosis remains dismal. The reasons for the poor prognosis are the lack of sensitive serum markers for early detection and screening of high-risk individuals as well as the limited treatment o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce26236cffeca747ec0c783c47343121
https://doi.org/10.1021/pr060011c
https://doi.org/10.1021/pr060011c