Zobrazeno 1 - 10
of 204
pro vyhledávání: '"Matthias P, Lutolf"'
Autor:
Devanjali Dutta, L. Francisco Lorenzo-Martín, François Rivest, Nicolas Broguiere, Lucie Tillard, Simone Ragusa, Nathalie Brandenberg, Sylke Höhnel, Damien Saugy, Sylvie Rusakiewicz, Krisztian Homicsko, George Coukos, Matthias P. Lutolf
Publikováno v:
npj Precision Oncology, Vol 8, Iss 1, Pp 1-7 (2024)
Abstract Immunotherapy has emerged as a new standard of care for certain cancer patients with specific cellular and molecular makeups. However, there is still an unmet need for ex vivo models able to readily assess the effectiveness of immunotherapeu
Externí odkaz:
https://doaj.org/article/500b8010d8694a5e80a921b03b5440e1
Autor:
Julien Pontis, Cyril Pulver, Christopher J. Playfoot, Evarist Planet, Delphine Grun, Sandra Offner, Julien Duc, Andrea Manfrin, Matthias P. Lutolf, Didier Trono
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-13 (2022)
The human genome harbors more than 4.5 million transposable element (TE)-derived insertions, the result of recurrent waves of invasion and internal propagation. Here they show that TEs belonging to evolutionarily recent subfamilies go on to regulate
Externí odkaz:
https://doaj.org/article/e82e220d3511449c9d94b1deeffca8a6
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-12 (2022)
Abstract Gastruloids are three-dimensional embryonic organoids that reproduce key features of early mammalian development in vitro with unique scalability, accessibility, and spatiotemporal similarity to real embryos. Recently, we adapted the gastrul
Externí odkaz:
https://doaj.org/article/6b73a89ac68a40559638c79fbbe08838
Autor:
Mehmet U. Girgin, Nicolas Broguiere, Sylke Hoehnel, Nathalie Brandenberg, Bastien Mercier, Alfonso Martinez Arias, Matthias P. Lutolf
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Previous approaches to derive embryoids either lack physiological morphology and signaling interactions, or are unconducive to model post-gastrulation development. Here the authors use a high-throughput approach to induce mouse embryonic stem cells i
Externí odkaz:
https://doaj.org/article/d7b6600beff74aaeac98ceb5354dc6d2
Autor:
Sonja Giger, Moritz Hofer, Marijana Miljkovic-Licina, Sylke Hoehnel, Nathalie Brandenberg, Romain Guiet, Martin Ehrbar, Esther Kleiner, Katharina Gegenschatz-Schmid, Thomas Matthes, Matthias P. Lutolf
Publikováno v:
APL Bioengineering, Vol 6, Iss 3, Pp 036101-036101-14 (2022)
In many leukemia patients, a poor prognosis is attributed either to the development of chemotherapy resistance by leukemic stem cells (LSCs) or to the inefficient engraftment of transplanted hematopoietic stem/progenitor cells (HSPCs) into the bone m
Externí odkaz:
https://doaj.org/article/ede4db85bc1f4ee29ddc191584cc3c49
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-10 (2020)
Abstract Human mammary epithelial cells can proliferate and reorganize into polarized multi-cellular constructs in-vitro, thereby functioning as an important model system in recapitulating key steps of in-vivo morphogenesis. Current approaches to con
Externí odkaz:
https://doaj.org/article/061c41c2313f4f678b24caa4dbe244d8
Autor:
Giovanni Sorrentino, Saba Rezakhani, Ece Yildiz, Sandro Nuciforo, Markus H. Heim, Matthias P. Lutolf, Kristina Schoonjans
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-10 (2020)
3D liver organoids hold great promise for regenerative medicine but the use of ill-defined matrices limits their potential. Here, the authors generate human and mouse liver organoids using a chemically defined matrix, and reveal a link between matrix
Externí odkaz:
https://doaj.org/article/c8411ec2ce88475e9d68ea7685bcb371
Autor:
Philipp S. Lienemann, Queralt Vallmajo‐Martin, Panagiota Papageorgiou, Ulrich Blache, Stéphanie Metzger, Anna‐Sofia Kiveliö, Vincent Milleret, Ana Sala, Sylke Hoehnel, Aline Roch, Raphael Reuten, Manuel Koch, Olaia Naveiras, Franz E. Weber, Wilfried Weber, Matthias P. Lutolf, Martin Ehrbar
Publikováno v:
Advanced Science, Vol 7, Iss 7, Pp n/a-n/a (2020)
Abstract The treatment of bone defects with recombinant bone morphogenetic protein‐2 (BMP‐2) requires high doses precluding broad clinical application. Here, a bioengineering approach is presented that strongly improves low‐dose BMP‐2‐based
Externí odkaz:
https://doaj.org/article/ff1b5c7bb89f4cc493ad1ee1b1a8a396
Autor:
Aline Roch, Sonja Giger, Mukul Girotra, Vasco Campos, Nicola Vannini, Olaia Naveiras, Samy Gobaa, Matthias P. Lutolf
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-12 (2017)
Haematopoietic stem cell (HSC) self-renewal is not sufficiently understood to recapitulate in vitro. Here, the authors generate gene signature and cell cycle hallmarks of single murine HSCs, and use identified endothelial receptors Esam and JamC as s
Externí odkaz:
https://doaj.org/article/2a3e06912cf94e5189f5b67d9ba35d31
Autor:
Delphine Blondel, Matthias P. Lutolf
Publikováno v:
CHIMIA, Vol 73, Iss 1-2 (2019)
Abstract: Organoids have stepped into the limelight as unique in vitro systems for modeling organ development, function and disease. This review provides a perspective on how chemically defined, bio-inspired hydrogels could be used for replacing ill-
Externí odkaz:
https://doaj.org/article/70ebec399ac04403b20565798359dfb5