Zobrazeno 1 - 10
of 129
pro vyhledávání: '"Matthias Nees"'
Autor:
Neeraj Prabhakar, Erica Långbacka, Ezgi Özliseli, Jesse Mattsson, Alaa Mahran, Ilida Suleymanova, Cecilia Sahlgren, Jessica M. Rosenholm, Malin Åkerfelt, Matthias Nees
Publikováno v:
Small Science, Vol 4, Iss 9, Pp n/a-n/a (2024)
Mesoporous silica nanoparticles (MSNs) have emerged as promising drug carriers that can facilitate targeted anticancer drug delivery, but efficiency studies relying on active targeting mechanisms remain elusive. This study implements in vitro 3D cocu
Externí odkaz:
https://doaj.org/article/6784873da6804a97b01d724e998aab78
Autor:
Syeda Afshan, Yu Gang Kim, Jesse Mattsson, Malin Åkerfelt, Pirkko Härkönen, Martin Baumgartner, Matthias Nees
Publikováno v:
Cancer Medicine, Vol 13, Iss 18, Pp n/a-n/a (2024)
Abstract Background Inhibition of androgen receptor (AR) signaling is the main treatment strategy in advanced prostate cancer (PCa). A subset of castration resistant prostate cancer (CRPC) bypasses the AR blockade by increased fibroblast growth facto
Externí odkaz:
https://doaj.org/article/50bad1de5a494228b47b0e9e0c70543a
Autor:
Arkadiusz Czerwonka, Joanna Kałafut, Shaoxia Wang, Alinda Anameric, Alicja Przybyszewska-Podstawka, Mervi Toriseva, Matthias Nees
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 177, Iss , Pp 116822- (2024)
Aberration of Notch signaling is one of the key events involved in the development and progression of head and neck squamous cell carcinoma (HNSCC). The Notch pathway controls the tissue-specific differentiation of normal squamous epithelial cells an
Externí odkaz:
https://doaj.org/article/dc173e8c518f48df9aacca0bb86ccdd1
Autor:
Noora Lehtinen, Janne Suhonen, Kiesha Rice, Eetu Välimäki, Mervi Toriseva, Johannes Routila, Perttu Halme, Melissa Rahi, Heikki Irjala, Ilmo Leivo, Markku Kallajoki, Matthias Nees, Teijo Kuopio, Sami Ventelä, Juha K. Rantala
Publikováno v:
Translational Oncology, Vol 44, Iss , Pp 101935- (2024)
Malignant tumors derived from the epithelium lining the nasal cavity region are termed sinonasal cancers, a highly heterogeneous group of rare tumors accounting for 3 – 5 % of all head and neck cancers. Progress with next-generation molecular profi
Externí odkaz:
https://doaj.org/article/1043b19b0c8148dc8cfad7e1e4daf8d5
Autor:
Arkadiusz Czerwonka, Joanna Kałafut, Shaoxia Wang, Alinda Anameric, Alicja Przybyszewska-Podstawka, Jesse Mattsson, Mahtab Karbasian, Doriane Le Manach, Mervi Toriseva, Matthias Nees
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-17 (2023)
Abstract Notch signalling is one of the key molecular pathways involved in cell-to-cell signal transduction. Although the mechanisms of action of the NOTCH receptors are already relatively well known, their biological implications remain unclear, esp
Externí odkaz:
https://doaj.org/article/9c02c842501f4c619df5ba8b69591f58
Autor:
Aini Hyytiäinen, Katja Korelin, Mervi Toriseva, Tommy Wilkman, Satu Kainulainen, Karri Mesimäki, Johannes Routila, Sami Ventelä, Heikki Irjala, Matthias Nees, Ahmed Al-Samadi, Tuula Salo
Publikováno v:
Cancer Cell International, Vol 23, Iss 1, Pp 1-22 (2023)
Abstract Objective Head and neck squamous cell carcinoma (HNSCC) is a highly aggressive tumor with a 5-year mortality rate of ~ 50%. New in vitro methods are needed for testing patients’ cancer cell response to anti-cancer treatments. We aimed to i
Externí odkaz:
https://doaj.org/article/c23305f8303945c3bb4173ddd2f38bea
Autor:
Nataliia Petruk, Sanni Tuominen, Malin Åkerfelt, Jesse Mattsson, Jouko Sandholm, Matthias Nees, Gennady G. Yegutkin, Arja Jukkola, Johanna Tuomela, Katri S. Selander
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
Abstract CD73 is a cell surface ecto-5′-nucleotidase, which converts extracellular adenosine monophosphate to adenosine. High tumor CD73 expression is associated with poor outcome among triple-negative breast cancer (TNBC) patients. Here we investi
Externí odkaz:
https://doaj.org/article/b2c631e7001b40c2910848b8522fac2a
Autor:
Virginia Murillo-Garzón, Irantzu Gorroño-Etxebarria, Malin Åkerfelt, Mikael Christer Puustinen, Lea Sistonen, Matthias Nees, James Carton, Jonathan Waxman, Robert M. Kypta
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-16 (2018)
Wnt11 has been shown to play a role in invasion and metastasis of prostate cancer. Here the authors show that in prostate cancer cells Wnt11 signals through the Fzd8 receptor and report an interaction between Fzd8 and TGF-β receptors regulating the
Externí odkaz:
https://doaj.org/article/13cee405e09b4dc9b930c14c87af3723
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-18 (2017)
Abstract Organotypic, three-dimensional (3D) cancer models have enabled investigations of complex microtissues in increasingly realistic conditions. However, a drawback of these advanced models remains the poor biological relevance of cancer cell lin
Externí odkaz:
https://doaj.org/article/e84ed3d368f84a2991bc5aec09dfa895
Autor:
Julia O. Misiorek, Alicja Przybyszewska-Podstawka, Joanna Kałafut, Beata Paziewska, Katarzyna Rolle, Adolfo Rivero-Müller, Matthias Nees
Publikováno v:
Cells, Vol 10, Iss 1, p 94 (2021)
The Notch signaling pathway is a critical player in embryogenesis but also plays various roles in tumorigenesis, with both tumor suppressor and oncogenic activities. Mutations, deletions, amplifications, or over-expression of Notch receptors, ligands
Externí odkaz:
https://doaj.org/article/d7367b4cb6fe4ba8a01dd4c3d2cfdc56