Retinol saturase coordinates liver metabolism by regulating ChREBP activity

Autor: Steffi Heidenreich, Nicole Witte, Pamela Weber, Isabel Goehring, Alexander Tolkachov, Christian von Loeffelholz, Stephanie Döcke, Michael Bauer, Martin Stockmann, Andreas F. H. Pfeiffer, Andreas L. Birkenfeld, Matthias Pietzke, Stefan Kempa, Matthias Muenzner, Michael Schupp

Publikováno v: Nature Communications, Vol 8, Iss 1, Pp 1-10 (2017)

Fatty liver is one of the major features of metabolic syndrome and its development is associated with deregulation of systemic lipid and glucose homeostasis. Here Heidenreich et al. show that retinol saturase is implicated in hepatic lipid metabolism

Externí odkaz: https://doaj.org/article/37c1221ca2244b489f045cd0721ad8d4

The glucose-sensing transcription factor ChREBP is targeted by proline hydroxylation

Autor: Manuela Sommerfeld, Na Yang, Matthias Muenzner, Konstantin M. Petricek, Nicole Witte, Michael Schupp, Pamela Weber, Antti M. Salo, Till Schütte, Isabel Goehring, Anne Schumann, Steffi Heidenreich, Heike Stephanowitz, Moritz Oster, Johanna Myllyharju, Eberhard Krause, Miriam Knauer

Publikováno v: J Biol Chem

Cellular energy demands are met by uptake and metabolism of nutrients like glucose. The principal transcriptional regulator for adapting glycolytic flux and downstream pathways like de novo lipogenesis to glucose availability in many cell types is ca

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a639b9db15d5bfcf6e25d36a7236e598
https://pubmed.ncbi.nlm.nih.gov/33023907

Retinol saturase coordinates liver metabolism by regulating ChREBP activity

Autor: Stefan Kempa, Christian von Loeffelholz, Andreas Pfeiffer, Isabel Goehring, Steffi Heidenreich, Matthias Muenzner, Michael Schupp, Andreas L. Birkenfeld, Michael Bauer, Martin Stockmann, S Döcke, Nicole Witte, Pamela Weber, Matthias Pietzke, Alexander Tolkachov

Publikováno v: Nature Communications, Vol 8, Iss 1, Pp 1-10 (2017)
Nat. Commun. 8:384 (2017)
Heidenreich, S, Witte, N, Weber, P, Goehring, I, Tolkachov, A, von Loeffelholz, C, Döcke, S, Bauer, M, Stockmann, M, Pfeiffer, A F H, Birkenfeld, A L, Pietzke, M, Kempa, S, Muenzner, M & Schupp, M 2017, ' Retinol saturase coordinates liver metabolism by regulating ChREBP activity ', Nature Communications, vol. 8, no. 1, pp. 384 . https://doi.org/10.1038/s41467-017-00430-w
Nature Communications

The liver integrates multiple metabolic pathways to warrant systemic energy homeostasis. An excessive lipogenic flux due to chronic dietary stimulation contributes to the development of hepatic steatosis, dyslipidemia and hyperglycemia. Here we show

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::64c34f10c626d3f651f12c19983f8e13
http://link.springer.com/article/10.1038/s41467-017-00430-w

Loss of the Hematopoietic Stem Cell Factor GATA2 in the Osteogenic Lineage Impairs Trabecularization and Mechanical Strength of Bone

Autor: Susanne Mathia, Sebastiaan H. Meijsing, Michael Schupp, Sascha Sauer, Thomas H. Ambrosi, Mario Thiele, Georg Seifert, Alexander Tolkachov, Matthias Muenzner, Melissa Bothe, Georg N. Duda, Marjo Salminen, Cornelius Fischer, Chung-Ting Han, Tim J. Schulz

Publikováno v: Molecular and Cellular Biology (Washington, DC)
Molecular and cellular biology, vol 38, iss 12

The transcription factor GATA2 is required for expansion and differentiation of hematopoietic stem cells (HSCs). In mesenchymal stem cells (MSCs), GATA2 blocks adipogenesis, but its biological relevance and underlying genomic events are unknown. We r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f7090151fba4d17643c078ef18254fa
https://europepmc.org/articles/PMC5974429/

Retinol binding protein 4 and its membrane receptors: a metabolic perspective

Autor: Matthias Muenzner, Ronja Fedders, Michael Schupp

Publikováno v: Hormone molecular biology and clinical investigation. 22(1)

Nearly a decade of intense research has passed since the first report linking circulating retinol binding protein 4 (RBP4) to the development of insulin resistance. By now, a variety of underlying mechanisms have been identified; some of them are adh

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0eda9cbdcac58e58db852826ccbbe119
https://pubmed.ncbi.nlm.nih.gov/25941915