Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Matthias Misslinger"'
Autor:
Simon Oberegger, Matthias Misslinger, Klaus Faserl, Bettina Sarg, Hesso Farhan, Hubertus Haas
Publikováno v:
Open Biology, Vol 14, Iss 6 (2024)
Aspergillus fumigatus is the predominant mould pathogen for humans. Adaption to host-imposed iron limitation has previously been demonstrated to be essential for its virulence. [2Fe–2S] clusters are crucial as cofactors of several metabolic pathway
Externí odkaz:
https://doaj.org/article/0576385144cc4bb8bc2cd8b0e5bde4e5
Publikováno v:
Metabolic Engineering Communications, Vol 15, Iss , Pp e00214- (2022)
Conditional promoters allowing both induction and silencing of gene expression are indispensable for basic and applied research. The xylP promoter (pxylP) from Penicillium chrysogenum was demonstrated to function in various mold species including Asp
Externí odkaz:
https://doaj.org/article/5a2d2d26b94f422796751180987b24ad
Autor:
Simon M. Hoser, Anne Hoffmann, Andreas Meindl, Maximilian Gamper, Jörg Fallmann, Stephan H. Bernhart, Lisa Müller, Melanie Ploner, Matthias Misslinger, Leopold Kremser, Herbert Lindner, Stephan Geley, Heiner Schaal, Peter F. Stadler, Alexander Huettenhofer
Publikováno v:
Genome Biology, Vol 21, Iss 1, Pp 1-35 (2020)
Abstract Background The presence of nuclear mitochondrial DNA (numtDNA) has been reported within several nuclear genomes. Next to mitochondrial protein-coding genes, numtDNA sequences also encode for mitochondrial tRNA genes. However, the biological
Externí odkaz:
https://doaj.org/article/ef5cde895d3e494985b30d2192d76385
Autor:
Ingo Bauer, Matthias Misslinger, Yana Shadkchan, Anna-Maria Dietl, Verena Petzer, Thomas Orasch, Beate Abt, Stefan Graessle, Nir Osherov, Hubertus Haas
Publikováno v:
Frontiers in Microbiology, Vol 10 (2019)
Current suboptimal treatment options of invasive fungal infections and emerging resistance of the corresponding pathogens urge the need for alternative therapy strategies and require the identification of novel antifungal targets. Aspergillus fumigat
Externí odkaz:
https://doaj.org/article/6beb846ebc9d4ba983f5d6b67108fe7e
Autor:
Matthias Misslinger, Mareike Thea Scheven, Peter Hortschansky, Manuel Sánchez López-Berges, Katharina Heiss, Nicola Beckmann, Thomas Heigl, Martin Hermann, Thomas Krüger, Olaf Kniemeyer, Axel A Brakhage, Hubertus Haas
Publikováno v:
PLoS Genetics, Vol 15, Iss 9, p e1008379 (2019)
Efficient adaptation to iron starvation is an essential virulence determinant of the most common human mold pathogen, Aspergillus fumigatus. Here, we demonstrate that the cytosolic monothiol glutaredoxin GrxD plays an essential role in iron sensing i
Externí odkaz:
https://doaj.org/article/d31ad98d678b4e83bb0839932928c100
Autor:
Matthias Misslinger, Milos Petrik, Joachim Pfister, Isabella Hubmann, Katerina Bendova, Clemens Decristoforo, Hubertus Haas
Publikováno v:
Journal of Fungi, Vol 7, Iss 9, p 734 (2021)
Fungal infections are a serious threat, especially for immunocompromised patients. Early and reliable diagnosis is crucial to treat such infections. The bacterially produced siderophore desferrioxamine B (DFO-B) is utilized by a variety of microorgan
Externí odkaz:
https://doaj.org/article/f58b69c377b84c4188d0fdeeec4a8aae
Autor:
Mario Aguiar, Thomas Orasch, Matthias Misslinger, Anna-Maria Dietl, Fabio Gsaller, Hubertus Haas
Publikováno v:
Journal of Fungi, Vol 7, Iss 9, p 768 (2021)
Siderophore-mediated acquisition of iron has been shown to be indispensable for the virulence of several fungal pathogens, the siderophore transporter Sit1 was found to mediate uptake of the novel antifungal drug VL-2397, and siderophores were shown
Externí odkaz:
https://doaj.org/article/950961c480ae4640aebf4207ed5a96e8
Autor:
Manuel Sánchez López-Berges, Mareike Thea Scheven, Peter Hortschansky, Matthias Misslinger, Clara Baldin, Fabio Gsaller, Ernst R. Werner, Thomas Krüger, Olaf Kniemeyer, Jakob Weber, Axel A. Brakhage, Hubertus Haas
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 14, p 7739 (2021)
The airborne fungus Aspergillus fumigatus causes opportunistic infections in humans with high mortality rates in immunocompromised patients. Previous work established that the bZIP transcription factor HapX is essential for virulence via adaptation t
Externí odkaz:
https://doaj.org/article/d99ccd7dfd014e79b14fb1b34f7c45ad
Autor:
Joachim Pfister, Milos Petrik, Katerina Bendova, Barbara Matuszczak, Ulrike Binder, Matthias Misslinger, Alexander Kühbacher, Fabio Gsaller, Hubertus Haas, Clemens Decristoforo
Publikováno v:
Journal of Fungi, Vol 7, Iss 7, p 558 (2021)
Invasive pulmonary aspergillosis (IPA) is a life-threatening form of fungal infection, primarily in immunocompromised patients and associated with significant mortality. Diagnostic procedures are often invasive and/or time consuming and existing anti
Externí odkaz:
https://doaj.org/article/2553c1494ae04245bd358a64a251449a
Publikováno v:
Journal of Fungi, Vol 6, Iss 2, p 73 (2020)
Invasive fungal infections such as aspergillosis are life-threatening diseases mainly affecting immuno-compromised patients. The diagnosis of fungal infections is difficult, lacking specificity and sensitivity. This review covers findings on the prec
Externí odkaz:
https://doaj.org/article/f3738b7a8fcb4cd38ab8a34f1865c99b