Substantiate a read-across hypothesis by using transcriptome data—A case study on volatile diketones

Autor: Christina Drake, Matthias M. Wehr, Walter Zobl, Jeannette Koschmann, David De Lucca, Britta A. Kühne, Tanja Hansen, Jan Knebel, Detlef Ritter, Jan Boei, Harry Vrieling, Annette Bitsch, Sylvia E. Escher

Publikováno v: Frontiers in Toxicology, Vol 5 (2023)

This case study explores the applicability of transcriptome data to characterize a common mechanism of action within groups of short-chain aliphatic α-, β-, and γ-diketones. Human reference in vivo data indicate that the α-diketone diacetyl induc

Externí odkaz: https://doaj.org/article/ef322cf5e85e456eb141e4eefa521a86

Integrate mechanistic evidence from new approach methodologies (NAMs) into a read-across assessment to characterise trends in shared mode of action.

Autor: Escher SE; Fraunhofer Institute for Toxicology and Experimental Medicine, Chemical Safety and Toxicology, Germany. Electronic address: sylvia.escher@item.fraunhofer.de., Aguayo-Orozco A; Novo Nordisk Foundation Center for Protein Research, University of Copenhagen, Denmark., Benfenati E; Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Milano, Italy., Bitsch A; Fraunhofer Institute for Toxicology and Experimental Medicine, Chemical Safety and Toxicology, Germany., Braunbeck T; Aquatic Ecology and Toxicology Group, Center for Organismal Studies, University of Heidelberg, Heidelberg, Germany., Brotzmann K; Aquatic Ecology and Toxicology Group, Center for Organismal Studies, University of Heidelberg, Heidelberg, Germany., Bois F; Certara UK Ltd, Simcyp Division, Sheffield, United Kingdom., van der Burg B; BioDetection Systems, Amsterdam, the Netherlands., Castel J; Instituto de Investigación Sanitaria La Fe, University of Valencia, Spain, CIBEREH., Exner T; Edelweiss Connect GmbH, Basel, Switzerland., Gadaleta D; Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Milano, Italy., Gardner I; Certara UK Ltd, Simcyp Division, Sheffield, United Kingdom., Goldmann D; University of Vienna, Department of Pharmaceutical Sciences, Division of Pharmaceutical Chemistry, Vienna, Austria., Hatley O; Certara UK Ltd, Simcyp Division, Sheffield, United Kingdom., Golbamaki N; Lhasa Limited, Leeds, United Kingdom., Graepel R; Leiden Academic Centre for Drug Research (LACDR), Leiden University, Leiden, the Netherlands., Jennings P; Vrije Universiteit Amsterdam, Amsterdam, the Netherlands., Limonciel A; Vrije Universiteit Amsterdam, Amsterdam, the Netherlands., Long A; Lhasa Limited, Leeds, United Kingdom., Maclennan R; Cyprotex, Cheshire, United Kingdom., Mombelli E; Institut national de l'environnement industriel et des risques, France., Norinder U; MTM Research Centre, Örebro University, Sweden., Jain S; University of Vienna, Department of Pharmaceutical Sciences, Division of Pharmaceutical Chemistry, Vienna, Austria., Capinha LS; Vrije Universiteit Amsterdam, Amsterdam, the Netherlands., Taboureau OT; Université de Paris, France., Tolosa L; Instituto de Investigación Sanitaria La Fe, University of Valencia, Spain, CIBEREH., Vrijenhoek NG; Leiden Academic Centre for Drug Research (LACDR), Leiden University, Leiden, the Netherlands., van Vugt-Lussenburg BMA; BioDetection Systems, Amsterdam, the Netherlands., Walker P; Cyprotex, Cheshire, United Kingdom., van de Water B; Leiden Academic Centre for Drug Research (LACDR), Leiden University, Leiden, the Netherlands., Wehr M; Fraunhofer Institute for Toxicology and Experimental Medicine, Chemical Safety and Toxicology, Germany., White A; Unilever Safety and Environmental Assurance Centre, Sharnbrook, Bedfordshire, United Kingdom., Zdrazil B; University of Vienna, Department of Pharmaceutical Sciences, Division of Pharmaceutical Chemistry, Vienna, Austria., Fisher C; Certara UK Ltd, Simcyp Division, Sheffield, United Kingdom.

Publikováno v: Toxicology in vitro : an international journal published in association with BIBRA [Toxicol In Vitro] 2022 Mar; Vol. 79, pp. 105269. Date of Electronic Publication: 2021 Oct 29.