Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Matthias Kist"'
Autor:
Axel Witt, Tatiana Goncharov, Yujung Michelle Lee, Matthias Kist, Monika Dohse, Jeff Eastham, Debra Dugger, Kim Newton, Joshua D. Webster, Domagoj Vucic
Publikováno v:
Cell Death and Disease, Vol 14, Iss 4, Pp 1-8 (2023)
Abstract XIAP is a caspase-inhibitory protein that blocks several cell death pathways, and mediates proper activation of inflammatory NOD2-RIP2 signaling. XIAP deficiency in patients with inflammatory diseases such as Crohn’s disease, or those need
Externí odkaz:
https://doaj.org/article/42740dc575bd483ca8f1e15a17296b06
Autor:
Sabrina Genßler, Eugen Leo, Christine Schuberth-Wagner, Markus Haake, Neha Vashist, Beatrice Haack, Birgitt Fischer, Kristin Eichler, Matthias Kist, Joerg Wischhusen
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 11, Iss Suppl 1 (2023)
Externí odkaz:
https://doaj.org/article/27a514e056894717a9a56526816cca58
Autor:
Florian Haun, Simon Neumann, Lukas Peintner, Katrin Wieland, Jüri Habicht, Carsten Schwan, Kristine Østevold, Maria Magdalena Koczorowska, Martin Biniossek, Matthias Kist, Hauke Busch, Melanie Boerries, Roger J. Davis, Ulrich Maurer, Oliver Schilling, Klaus Aktories, Christoph Borner
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
Gliotoxin (GT), produced by the pulmonary pathogen A. fumigatus, induces detachment-induced apoptosis (anoikis) of lung epithelial cells and likely promotes invasion. Here, the authors show that GT covalently modifies integrins at the RGD binding sit
Externí odkaz:
https://doaj.org/article/bff8d4a17fd0485f978c20944875f2fe
Autor:
László G. Kőműves, Merone Roose-Girma, Joshua D. Webster, Tatiana Goncharov, Domagoj Vucic, Kim Newton, Debra L. Dugger, Matthias Kist, Charles Yu
Publikováno v:
Cell Death and Differentiation
Receptor-interacting protein 1 (RIP1; RIPK1) is a key regulator of multiple signaling pathways that mediate inflammatory responses and cell death. TNF-TNFR1 triggered signaling complex formation, subsequent NF-κB and MAPK activation and induction of
Autor:
Matthias Kist, Domagoj Vucic
Publikováno v:
EMBO J
Various forms of cell death have been identified over the last decades with each relying on a different subset of proteins for the activation and execution of their respective pathway(s). In addition to the three best characterized pathways-apoptosis
Publikováno v:
Cell Death and Differentiation
The ubiquitin system is complex, multifaceted, and is crucial for the modulation of a vast number of cellular processes. Ubiquitination is tightly regulated at different levels by a range of enzymes including E1s, E2s, and E3s, and an array of DUBs.
Autor:
Wyne P. Lee, Donald S. Kirkpatrick, Matthias Kist, Joshua D. Webster, Domagoj Vucic, Kim Newton, Eugene Varfolomeev, Xiumin Wu, M. Cristina de Almagro, Kebing Yu, Jeremy Murray, Stefanie Duttler, Tatiana Goncharov, Anita Izrael-Tomasevic
Publikováno v:
Cell Death and Differentiation
Proper regulation of cell death signaling is crucial for the maintenance of homeostasis and prevention of disease. A caspase-independent regulated form of cell death called necroptosis is rapidly emerging as an important mediator of a number of human
Autor:
Melanie Boerries, Martin L. Biniossek, Hauke Busch, Maria Magdalena Koczorowska, Carsten Schwan, Klaus Aktories, Simon Neumann, Florian Haun, Katrin Wieland, Oliver Schilling, Christoph Borner, Ulrich Maurer, Lukas Peintner, Kristine Østevold, Jüri Habicht, Matthias Kist, Roger J. Davis
Publikováno v:
Nature Communications
Nature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
Nature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
Anoikis is a form of apoptosis induced by cell detachment. Integrin inactivation plays a major role in the process but the exact signalling pathway is ill-defined. Here we identify an anoikis pathway using gliotoxin (GT), a virulence factor of the fu